Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL676694 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL10596636 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL28234438 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL27241859 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL11684362 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL10681574 | 0.82 | CA4 (0.50) | — | |
| Hydrochloric Acid SCHEMBL15638259 | 0.82 | CA4 (0.50) | — | |
| Hydrochloric Acid SCHEMBL11064222 | 0.82 | CA4 (0.50) | — | |
| Hydrochloric Acid SCHEMBL7423862 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL14635381 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978252-A | Chiral benzomorphane derivative and preparation method and pharmaceutical application thereof | 复旦大学 | 2020-11-24 | — | — | CN | disclosed |
| EP-3221304-B1 | NOVEL CARBOXYLIC ACID COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | LILLY CO ELI (US) | 2019-07-24 | — | — | EP | disclosed |
| US-20180251446-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | LILLY CO ELI (US) | 2018-09-06 | — | — | US | disclosed |
| US-9969714-B2 | Carboxylic acid compounds useful for inhibiting microsomal prostaglandin E2 synthase-1 | ELI LILLY AND COMPANY (US) | 2018-05-15 | — | — | US | disclosed |
| EP-2570459-B1 | POLYAMIDE RESIN COMPOSITION | MITSUBISHI GAS CHEMICAL CO (JP) | 2018-02-21 | — | — | EP | disclosed |
| US-20170313679-A1 | Novel Carboxylic Acid Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1 | ELI LILLY AND COMPANY | 2017-11-02 | — | — | US | disclosed |
| EP-3221304-A1 | NOVEL CARBOXYLIC ACID COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | Eli Lilly and Company (US) | 2017-09-27 | — | — | EP | disclosed |
| US-9475752-B2 | Method for manufacturing 3,4,5-tricaffeoylquinic acid | FUJIFILM CORPORATION (JP) | 2016-10-25 | — | — | US | disclosed |
| WO-2016069374-A1 | NOVEL CARBOXYLIC ACID COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 | ELI LILLY AND COMPANY (US) | 2016-05-06 | — | — | WO | disclosed |
| US-20160023986-A1 | METHOD FOR MANUFACTURING 3,4,5-TRICAFFEOYLQUINIC ACID | FUJIFILM CORPORATION (JP) | 2016-01-28 | — | — | US | disclosed |
| US-6645711-B2 | Silver halide photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2003-11-11 | — | — | US | disclosed |
| US-6596470-B2 | Silver halide emulsion; reducible silver compound; fine particles of developer | FUJI PHOTO FILM CO., LTD. (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20030129551-A1 | Silver halide photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2003-07-10 | — | — | US | disclosed |
| US-20020110763-A1 | Heat-developable light-sensitive material and image-forming method using the same | FUJIFILM CORPORATION (JP) | 2002-08-15 | — | — | US | disclosed |
| US-6420181-B1 | DETECTING PREFERENTIAL PARTICLE IN SOLUTION; OBTAIN SOLUTION CONTAINING PARTICLE, MIX WITH SOLVENT, INSERT INTO TUBE, INCUBATE WITH CHROMOGENIC DETECTION INDICATOR, MONITOR SAMPLE FOR SIGNAL | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2002-07-16 | — | — | US | disclosed |
| US-5663447-A | Process for the preparation of 2,2 dialkyl-arylidene-cycloalkanones | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-02 | — | — | US | disclosed |
| US-5223410-A | Immunizing with antigen, removing antibody-producing cells, forming hybridoma by fusing with immortalizing cells, propagation and havesting | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5120834-A | Probe to detect antigen | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1992-06-09 | — | — | US | disclosed |
| US-5091512-A | Immunoassay for determination of plasma fibrinogen levels | AMERICAN BIOGENETIC SCIENCES, INC. (US) | 1992-02-25 | — | — | US | disclosed |
| US-4780398-A | MIXTURE OF FERRIL AMINOPOLYCARBOXYLIC ACID COMPLEX, MERCAPTO SUBSTITUTED NITROGEN COMPOUND, AND (ALKYL-SUBSTITUTE) VINYLPYRROLIDONE POLYMER | OLIN HUNT SPECIALTY PRODUCTS, INC. (US) | 1988-10-25 | — | — | US | disclosed |