Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP4B1 | P13584 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | CYP2A7 | P20853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7722657 | 0.82 | CALM1 (0.38) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7996394 | 0.81 | CA12 (0.35) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2598020 | 0.78 | CYP1A1 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL161694 | 0.77 | ACHE (0.44) | ALDH1A1CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL2154934 | 0.77 | ALDH1A1 (0.38) | CA12CA1CA2CA7CA9 | |
| SCHEMBL1810937 | 0.77 | CA12 (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL8121638 | 0.77 | NQO2 (0.40) | CYP1A2ALDH1A1CYP3A4CYP2C19MAPT | |
| SCHEMBL2235124 | 0.76 | CA12 (0.41) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2164088 | 0.76 | CA12 (0.41) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3393076 | 0.76 | CA12 (0.41) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 362 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114591306-B | 1,4 naphthoquinone STAT3 inhibitor of 1,2,4-triazole ring and application thereof | 陕西中医药大学 | 2024-03-01 | — | — | CN | claimed |
| US-11369584-B2 | Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis | ZHENGZHOU UNIVERSITY (CN) | 2022-06-28 | — | — | US | claimed |
| CN-114591306-A | 1,4 naphthoquinone STAT3 inhibitor of 1,2,4-triazole ring and application thereof | 陕西中医药大学 | 2022-06-07 | — | — | CN | claimed |
| CN-109730990-B | Application of 15-benzylidene-14-deoxy-11, 12-dehydroandrographolide derivative in anti-fibrosis drugs | 郑州大学 | 2021-07-02 | — | — | CN | claimed |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2021-05-13 | — | — | US | claimed |
| EP-3038621-B1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RES INSTITUTE (US) | 2020-12-02 | — | — | EP | claimed |
| EP-3608313-A1 | 15-IDENE-14-DEOXY-11,12-DEHYDROANDROGRAPHOLIDE DERIVATIVE AND APPLICATION THEREOF IN PREPARING ANTI-FIBROSIS DRUGS | Zhengzhou University (CN) | 2020-02-12 | — | — | EP | claimed |
| US-20200030280-A1 | ANDROGRAPHOLIDE DERIVATIVES AND METHOD OF USING THE SAME FOR TREATMENT OR PREVENTION OF FIBROSIS | ZHENGZHOU UNIVERSITY (CN) | 2020-01-30 | — | — | US | claimed |
| CN-109730990-A | Application of the 15- benzyl subunit -14- deoxidation -11,12- andrographolide in anti-fibrosis medicine | 郑州大学 | 2019-05-10 | — | — | CN | claimed |
| CN-106946821-B | Andrographolidume derivative and its 3,19 carboxylates are preparing the application in anti-hepatic fibrosis medicines | 郑州大学 | 2019-04-19 | — | — | CN | claimed |
| WO-2005105757-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-10 | — | — | WO | claimed |
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-03 | — | — | US | claimed |
| CN-1630554-A | Trimerisation of olefins using a catalyst containing chromium, molybdenum or tungsten and a ligand containing phosphorus, arsenic or antimony | BP CHEM INT LTD (GB) | 2005-06-22 | — | — | CN | claimed |
| CN-1612856-A | 1,3-diarylprop-2-en-1-ones, compositions containing same and use thereof | AVENTIS PHARMA SA (FR) | 2005-05-04 | — | — | CN | claimed |
| EP-1453790-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | Aventis Pharma S.A. (FR) | 2004-09-08 | — | — | EP | claimed |
| US-20040147584-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2004-07-29 | — | — | US | claimed |
| EP-0463488-B2 | O-Benzyl oxime ethers and fungicides containing them | BASF AG (DE) | 2004-04-21 | — | — | EP | claimed |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | AVENTIS PHARMA S.A. | 2003-08-14 | — | — | US | claimed |
| WO-2003048106-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2003-06-12 | — | — | WO | claimed |
| CN-1107158-A | Polysubstituted 2-amino-thiazole derivatives | SANOFI ELF (FR) | 1995-08-23 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | IL1B, IL1A, IL6 | CA12 3132/4885CA1 854/4885CA2 1280/4885 |
| US-20200030280-A1 | ANDROGRAPHOLIDE DERIVATIVES AND METHOD OF USING THE SAME FOR TREATMENT OR PREVENTION OF FIBROSIS | MMP1, CYP27A1, PYGL | CA12 3234/4885CA1 4626/4885CA2 4226/4885 |
| US-20040147584-A2 | 1,3-DIARYLPROP-2-EN-1-ONES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | MCL1, ENPP1, MYC | CA12 4444/4885CA1 4661/4885CA2 4842/4885 |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | CA12 1944/4885CA1 1346/4885CA2 2747/4885 |
| US-11369584-B2 | Andrographolide derivatives and method of using the same for treatment or prevention of fibrosis | MMP1, CYP27A1, PYGL | CA12 3234/4885CA1 4626/4885CA2 4226/4885 |
| US-20030153611-A1 | 1,3-Diarylprop-2-en-1-ones, compositions containing them and use thereof | MCL1, ENPP1, MYC | CA12 4444/4885CA1 4661/4885CA2 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.