Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 known ✓ | P36544 | 6/20 | 0.47 |
| ▸ | CHRNB4 known ✓ | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 known ✓ | P32297 | 5/20 | 0.47 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.41 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7263495 | 1.00 | KDM4E (0.52) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL28163438 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL3641370 | 0.98 | CHRNA7 (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL425184 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL10810476 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Bromide SCHEMBL28903213 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL27861401 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL9653571 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Hydrochloric Acid SCHEMBL7263493 | 0.98 | KDM4E (0.56) | KDM4EALDH1A1TDP1CYP1A2TP53 | |
| Bromide SCHEMBL3641373 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1TDP1CYP1A2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110423223-A | A kind of preparation method and its epoxidation application of Phthalazinone biphenol monomer | UNIV DALIAN TECH | 2019-11-08 | — | — | CN | claimed |
| CN-110127906-A | It is the method for reverse osmosis concentrated water desalination using benzyltriethylammoinium chloride | 兖州煤业股份有限公司 | 2019-08-16 | — | — | CN | claimed |
| CN-106632122-B | Benzoxazoles benzene oxycarboxylic acid amides compound and preparation method thereof | 江苏富鼎化学有限公司 | 2019-05-14 | — | — | CN | claimed |
| CN-109734882-A | A kind of three-glycidyl isocyanurate curing thermal transfer powdery paints carboxyl end group saturated polyester resin and its synthetic method | 安徽神剑新材料股份有限公司 | 2019-05-10 | — | — | CN | claimed |
| CN-109180926-A | A kind of preparation method of polyether-type multi-thioalcohol compound | 山东益丰生化环保股份有限公司 | 2019-01-11 | — | — | CN | claimed |
| CN-109096500-A | A kind of organic siliconresin microemulsion and preparation method | 福建拓烯新材料科技有限公司 | 2018-12-28 | — | — | CN | claimed |
| CN-108748530-A | A kind of preparation method of mildew preventing agent for wood | 俞小峰 | 2018-11-06 | — | — | CN | claimed |
| CN-108659084-A | A kind of preparation method of 17 β-carboxylic acids chloromethane esters steroidal compounds | 天津药业研究院有限公司 | 2018-10-16 | — | — | CN | claimed |
| CN-108659090-A | A kind of preparation method of 17 β-thiocarboxylic acids chloromethane esters steroidal compounds | 天津药业研究院有限公司 | 2018-10-16 | — | — | CN | claimed |
| CN-108440383-A | A kind of preparation method of Rivaroxaban intermediate | 浙江永太科技股份有限公司 | 2018-08-24 | — | — | CN | claimed |
| CN-105968247-B | A kind of lab scale synthesis of carboxyl-terminated liquid fluorine elastomer and curing | 北京化工大学 | 2018-06-29 | — | — | CN | claimed |
| CN-107950568-A | Sanitizer formulations, application method and application | 中国人民解放军陆军防化学院 | 2018-04-24 | — | — | CN | claimed |
| CN-105908550-B | A kind of method of the separation and Extraction lignin from Eucalyptus | 华南理工大学 | 2017-12-01 | — | — | CN | claimed |
| CN-106632122-A | Benzoxazole phenoxy carboxylic acid amide compound and preparation method thereof | 江苏富鼎化学有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-106496072-A | A kind of preparation method of MDI | 江苏嘉隆化工有限公司 | 2017-03-15 | — | — | CN | claimed |
| CN-105860048-A | Bisphenol Z-bisphenol AF copolymer polycarbonate adhesive resin as well as preparation method thereof and application | 江苏理工学院 | 2016-08-17 | — | — | CN | claimed |
| CN-102701230-A | Preparation method for inorganic-organic modified attapulgite clay | XUYI ATTAPULGITE APPLIED TECHNOLOGY R & D CT LANZHOU INST OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCI | 2012-10-03 | — | — | CN | claimed |
| CN-107540670-B | Preparation method of 1- (3-chloropyrazolo [1,5a ] -4,5,6, 7-tetrahydropyridine-2-yl) -5-methylamine pyrazole-4-carbonitrile | 湖北相和精密化学有限公司 | 2021-08-13 | — | — | CN | disclosed |
| EP-0623577-A1 | Preparation of halogenides and salts of carboxylic acids | Solvay Fluor und Derivate GmbH (DE) | 1994-11-09 | — | — | EP | disclosed |
| CN-1066852-A | Steroid derivatives, their preparation and use, and novel intermediates | ROUSSEL UCLAF (FR) | 1992-12-09 | — | — | CN | disclosed |