Sugi Predict

Sugi Predict / Compounds / SCHEMBL802249

SCHEMBL802249

SCHEMBL802249

Cn1cc(C(C)(C)C)c(C(F)(F)F)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.39
▸ CYP2C19 P33261 2/20 0.38
▸ POLB P06746 2/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ IDH1 O75874 1/20 0.37
▸ CYP1A2 P05177 3/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ HTT P42858 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ PDE3B Q13370 1/20 0.33
▸ PDE3A Q14432 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ PKM P14618 1/20 0.33
▸ BRD4 O60885 1/20 0.32
▸ PRMT5 O14744 1/20 0.32
▸ WDR77 Q9BQA1 1/20 0.32
▸ SGK1 O00141 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26738545 0.88 GAA (0.33) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL15623924 0.87 GAA (0.41) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL22067477 0.84 GAA (0.37) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL26275972 0.83 GAA (0.36) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL13868035 0.81 GAA (0.38) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL12060404 0.81 GAA (0.38) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL25587175 0.79 ADORA2A (0.31) —
SCHEMBL26275291 0.79 GAA (0.33) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL21652322 0.76 GAA (0.35) GAACYP2C19POLBCYP3A4LMNA
SCHEMBL24238830 0.75 LRRK2 (0.38) CYP1A2L3MBTL1LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240228484-A1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-07-11 — — US disclosed
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-06-27 — — US disclosed
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-06-27 — — US disclosed
US-11802111-B2 Cyclobutyl amide monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-10-31 — — US disclosed
US-11802111-B2 Cyclobutyl amide monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-10-31 — — US disclosed
US-20220033412-A1 6-HYDROXY-8-OXATRICYCLO[3.2.1.02,4]OCTANE-2-CARBOXAMIDE DERIVATIVES FOR INDUCING CHONDROGENESIS FOR TREATING JOINT DAMAGE NOVARTIS AG (CH) 2022-02-03 — — US disclosed
US-20210371420-A1 INHIBITORS OF KINASE NETWORKS AND USES THEREOF PURDUE RESEARCH FOUNDATION 2021-12-02 — — US disclosed
US-11178870-B2 Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients MITSUI CHEMICALS AGRO, INC. (JP) 2021-11-23 — — US disclosed
US-20210300906-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS NXERA PHARMA UK LIMITED (GB) 2021-09-30 — — US disclosed
US-11040973-B2 Inhibitors of kinase networks and uses thereof PURDUE RESEARCH FOUNDATION 2021-06-22 — — US disclosed
US-7932283-B2 Fungicide N-cyclopropyl-sulfonylamide derivatives BAYER CROPSCIENCE AG (DE) 2011-04-26 — — US disclosed
US-20110046152-A1 Amide Compounds, Preparation Methods and Uses Thereof SINOCHEM CORPORATION 2011-02-24 — — US disclosed
US-20100144817-A1 FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES BAYER SAS (FR) 2010-06-10 — — US disclosed
US-20100144817-A1 FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES BAYER SAS (FR) 2010-06-10 — — US disclosed
US-20100130468-A1 INDOLE CARBOXAMIDES AS IKK2 INHIBITORS GLAXOSMITHKLINE LLC 2010-05-27 — — US disclosed
US-20100130468-A1 INDOLE CARBOXAMIDES AS IKK2 INHIBITORS GLAXOSMITHKLINE LLC 2010-05-27 — — US disclosed
US-20100010048-A1 Fungicide 2-pyridyl-methylene-carboxamide derivatives BAYER INTELLECTUAL PROPERTY GMBH (DE) 2010-01-14 — — US disclosed
US-20090326016-A1 FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES BAYER INTELLECTUAL PROPERTY GMBH (DE) 2009-12-31 — — US disclosed
US-20090137611-A1 Fungicide N-Cyclopropyl-Sulfonylamide Derivatives BAYER CROPSCIENCE AG (DE) 2009-05-28 — — US disclosed
US-20080312435-A1 Imine Compound TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-12-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220033412-A1 6-HYDROXY-8-OXATRICYCLO[3.2.1.02,4]OCTANE-2-CARBOXAMIDE DERIVATIVES FOR INDUCING CHONDROGENESIS FOR TREATING JOINT DAMAGE COL2A1, COL1A1, HCAR1 GAA 3894/4885CYP2C19 1739/4885POLB 3386/4885
US-20080312435-A1 Imine Compound CNR1, CNR2, HRH4 GAA 4866/4885CYP2C19 546/4885POLB 4390/4885
US-20110046152-A1 Amide Compounds, Preparation Methods and Uses Thereof ACHE, MGAM, PGLS GAA 1526/4885CYP2C19 2111/4885POLB 4398/4885
US-20240228484-A1 MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, PNLIP GAA 229/4885CYP2C19 635/4885POLB 492/4885
US-11178870-B2 Pyridone compounds and agricultural and horticultural fungicides containing the same as active ingredients PNPO, CYP4X1, PDXK GAA 1772/4885CYP2C19 28/4885POLB 4045/4885
US-20210300906-A1 PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS HRH4, HRH3, HDAC3 GAA 4421/4885CYP2C19 1344/4885POLB 4378/4885
US-11040973-B2 Inhibitors of kinase networks and uses thereof KDM1B, JMJD6, KDM1A GAA 2509/4885CYP2C19 4331/4885POLB 2022/4885
US-20240208902-A1 CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS MGLL, LPL, PNLIP GAA 260/4885CYP2C19 746/4885POLB 846/4885
US-20210371420-A1 INHIBITORS OF KINASE NETWORKS AND USES THEREOF KDM1B, JMJD6, KDM1A GAA 2509/4885CYP2C19 4331/4885POLB 2022/4885
US-20100130468-A1 INDOLE CARBOXAMIDES AS IKK2 INHIBITORS IDO2, IDO1, NFKBIA GAA 4500/4885CYP2C19 1531/4885POLB 2418/4885
US-20100144817-A1 FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES CBR3, NRDC, NAT1 GAA 2419/4885CYP2C19 446/4885POLB 4457/4885
US-11802111-B2 Cyclobutyl amide monoacylglycerol lipase modulators MGLL, LPL, PNLIP GAA 247/4885CYP2C19 734/4885POLB 841/4885
US-20100010048-A1 Fungicide 2-pyridyl-methylene-carboxamide derivatives CYP51A1, ME2, ME3 GAA 1011/4885CYP2C19 57/4885POLB 3219/4885
US-20090137611-A1 Fungicide N-Cyclopropyl-Sulfonylamide Derivatives CYP51A1, ERG28, CBR3 GAA 291/4885CYP2C19 120/4885POLB 4713/4885
US-20090326016-A1 FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES CBR3, CBR1, CYCS GAA 2352/4885CYP2C19 136/4885POLB 3437/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.