Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL108265 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28602467 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8050695 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11421067 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11420338 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8554606 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9146701 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7138382 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11430737 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL11571153 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100478369-C | Olefin and omega-silane-alpha-olefin copolymer and its preparing method | CHINESE ACAD INST CHEMISTRY (CN) | 2009-04-15 | — | — | CN | claimed |
| CN-1935858-A | Olefin and omega-silane-alpha-olefin copolymer and its preparing method | CHINESE ACAD INST CHEMISTRY (CN) | 2007-03-28 | — | — | CN | claimed |
| CN-1876692-A | Method for preparation of functional polyolefin | CHINA PETROLEUM & CHEMICAL (CN) | 2006-12-13 | — | — | CN | claimed |
| EP-0040741-B1 | PROCESS FOR THE PREPARATION OF CHLOROFORMIC-ACID ARYL ESTERS | BAYER AG (DE) | 1983-06-08 | — | — | EP | claimed |
| US-4366102-A | Process for the preparation of chloroformic acid aryl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-12-28 | — | — | US | claimed |
| US-4133831-A | CARBON MONOXIDE, CHLORINE, AND A PHOSPHINE CHLORIDE COMPOUND AS CATALYST | UBE INDUSTRIES, LTD. (JP) | 1979-01-09 | — | — | US | claimed |
| CN-100478369-C | Olefin and omega-silane-alpha-olefin copolymer and its preparing method | CHINESE ACAD INST CHEMISTRY (CN) | 2009-04-15 | — | — | CN | disclosed |
| CN-1935858-A | Olefin and omega-silane-alpha-olefin copolymer and its preparing method | CHINESE ACAD INST CHEMISTRY (CN) | 2007-03-28 | — | — | CN | disclosed |
| CN-1876692-A | Method for preparation of functional polyolefin | CHINA PETROLEUM & CHEMICAL (CN) | 2006-12-13 | — | — | CN | disclosed |
| US-6160117-A | Chemical process | ZENECA LIMITED (GB) | 2000-12-12 | — | — | US | disclosed |
| US-4366102-A | Process for the preparation of chloroformic acid aryl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-12-28 | — | — | US | disclosed |
| US-4155932-A | REACTING CHLORINE AND CARBON MONOXIDE WITH A TERTIARY PHOSPHINE OXIDE | UBE INDUSTRIES, INC. (JP) | 1979-05-22 | — | — | US | disclosed |
| US-4133831-A | CARBON MONOXIDE, CHLORINE, AND A PHOSPHINE CHLORIDE COMPOUND AS CATALYST | UBE INDUSTRIES, LTD. (JP) | 1979-01-09 | — | — | US | disclosed |