SCHEMBL8443205

SCHEMBL8443205

CCc1ccc(CNC(C)C)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
L3MBTL1 Q9Y468 3/20 0.44
ALDH1A1 P00352 3/20 0.44
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
MAPK1 P28482 2/20 0.44
APAF1 O14727 1/20 0.44
USP2 O75604 1/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
ALOX15 P16050 1/20 0.44
ALOX12 P18054 1/20 0.44
CASP1 P29466 1/20 0.44
BLM P54132 1/20 0.44
HSD17B10 Q99714 1/20 0.44
SIGMAR1 Q99720 1/20 0.42
LTA4H P09960 1/20 0.41
PARP1 P09874 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3271284 0.90 SIGMAR1 (0.48) LMNAALDH1A1MAPK1POLBALOX15
SCHEMBL13164692 0.83 ALDH1A1 (0.49) LMNAALDH1A1MAPK1SIGMAR1LTA4H
SCHEMBL13520306 0.82 SIGMAR1 (0.48) L3MBTL1ALDH1A1ALOX15CASP1HSD17B10
SCHEMBL16870109 0.82 SIGMAR1 (0.45) KMT2ASIGMAR1LTA4HPARP1
SCHEMBL10118898 0.82 LMNA (0.41) LMNAL3MBTL1ALDH1A1MEN1KMT2A
SCHEMBL23008642 0.81 SLC2A1 (0.38) SIGMAR1LTA4HPARP1SLC2A1
SCHEMBL8851013 0.81 SMN1; SMN2 (0.58) L3MBTL1ALDH1A1MEN1KMT2AMAPK1
SCHEMBL3440308 0.81 LOXL2 (0.50) LMNAALDH1A1MAPK1POLBMAPT
SCHEMBL14438280 0.79 IDO1 (0.52) L3MBTL1ALDH1A1MEN1KMT2AMAPK1
SCHEMBL6613714 0.79 ITGB1 (0.53) ALDH1A1SIGMAR1LTA4HPARP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2024-01-25 US disclosed
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-27 US disclosed
US-20230219945-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-13 US disclosed
US-11679109-B2 SMARCA degraders and uses thereof KYMERA THERAPEUTICS, INC. (US) 2023-06-20 US disclosed
US-20230149549-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-18 US disclosed
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-05-04 US disclosed
US-20230110180-A1 CDK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-04-13 US disclosed
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors KEZAR LIFE SCIENCES (US) 2023-02-14 US disclosed
US-11560422-B2 Sulfonamide-containing linkage systems for drug conjugates ZYMEWORKS INC. 2023-01-24 US disclosed
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2022-12-22 US disclosed
US-20220340570-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2022-10-27 US disclosed
US-20210228562-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2021-07-29 US disclosed
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS ENODIA THERAPEUTICS SAS (FR) 2021-03-18 US disclosed
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK 2021-03-04 US disclosed
US-20170087258-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK 2017-03-30 US disclosed
US-20170029490-A1 SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES ZYMEWORKS INC. (CA) 2017-02-02 US disclosed
EP-1857459-A2 Pyrazolopyrimidine compound and a process for preparing the same TANABE SEIYAKU CO., LTD. (JP) 2007-11-21 EP disclosed
US-20030153754-A1 Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands NEUROGEN CORPORATION, A CORPORATION OF THE STATE OF DELAWARE 2003-08-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230135894-A1 MK2 DEGRADERS AND USES THEREOF MKNK2, MKRN3, DUS2 LMNA 4560/4885L3MBTL1 4553/4885ALDH1A1 2904/4885
US-20210060188-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS FCGR2A, PAICS, CD47 LMNA 2921/4885L3MBTL1 796/4885ALDH1A1 2533/4885
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 LMNA 1656/4885L3MBTL1 1394/4885ALDH1A1 2776/4885
US-11578055-B2 Triazacyclododecansulfonamide (“TCD”)-based protein secretion inhibitors SEC61B, SEC61A1, SEC61G LMNA 4550/4885L3MBTL1 4760/4885ALDH1A1 4848/4885
US-20240024318-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 LMNA 341/4885L3MBTL1 2934/4885ALDH1A1 2230/4885
US-20230149549-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCB1, SMARCE1 LMNA 980/4885L3MBTL1 1827/4885ALDH1A1 3473/4885
US-20230219945-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 LMNA 1656/4885L3MBTL1 1394/4885ALDH1A1 2776/4885
US-20170087258-A1 TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS FCGR2A, PAICS, CD47 LMNA 2921/4885L3MBTL1 796/4885ALDH1A1 2533/4885
US-20220340570-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 LMNA 1656/4885L3MBTL1 1394/4885ALDH1A1 2776/4885
US-11679109-B2 SMARCA degraders and uses thereof SMARCA1, SMARCA2, SMARCC2 LMNA 341/4885L3MBTL1 2934/4885ALDH1A1 2230/4885
US-11560422-B2 Sulfonamide-containing linkage systems for drug conjugates MPST, TPST2, SULT1A1 LMNA 1797/4885L3MBTL1 1016/4885ALDH1A1 1011/4885
US-20210228562-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 LMNA 1656/4885L3MBTL1 1394/4885ALDH1A1 2776/4885
US-20230110180-A1 CDK2 DEGRADERS AND USES THEREOF CDK2, CDK20, CDK1 LMNA 1186/4885L3MBTL1 2534/4885ALDH1A1 3701/4885
US-20220402891-A1 TRIAZACYCLODODECANSULFONAMIDE (TCD)-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4448/4885L3MBTL1 4748/4885ALDH1A1 4834/4885
US-20030153754-A1 Fused pyrrolecarboxamides; a new class of GABA brain receptor ligands GABRB1, GABRB3, GABRB2 LMNA 3033/4885L3MBTL1 967/4885ALDH1A1 1833/4885
US-20210078974-A1 TRIAZACYCLODODECANSULFONAMIDE (\"TCD\")-BASED PROTEIN SECRETION INHIBITORS SEC61B, SEC61A1, SEC61G LMNA 4555/4885L3MBTL1 4721/4885ALDH1A1 4817/4885
US-20170029490-A1 SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES MPST, TPST2, SULT1A1 LMNA 1797/4885L3MBTL1 1016/4885ALDH1A1 1011/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.