SCHEMBL865129

SCHEMBL865129

CN(C)C(=O)c1ccc(COCc2ccc(C(=O)N(C)C)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 1/20 0.58
▸ ALDH1A1 P00352 6/20 0.57
▸ HPGD P15428 3/20 0.57
▸ SMN1; SMN2 Q16637 2/20 0.57
▸ EPHX2 P34913 1/20 0.47
▸ NR1H4 Q96RI1 1/20 0.47
▸ TBXAS1 P24557 1/20 0.45
▸ NPC1 O15118 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ RAB9A P51151 1/20 0.45
▸ PDK2 Q15119 2/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ CYP2C9 P11712 1/20 0.44
▸ PDK1 Q15118 1/20 0.44
▸ PDK3 Q15120 1/20 0.44
▸ PDK4 Q16654 1/20 0.44
▸ BRD4 O60885 1/20 0.43
▸ ACACB O00763 1/20 0.43
▸ KDM4E B2RXH2 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14101266 0.88 HSD11B1 (0.52) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL16242079 0.86 ALDH1A1 (0.55) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL14100861 0.86 HSD11B1 (0.51) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL17758155 0.85 HSD11B1 (0.50) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL7745696 0.85 ALDH1A1 (0.53) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL16242078 0.85 ALDH1A1 (0.53) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL18193472 0.85 ALDH1A1 (0.53) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL21015325 0.82 ALDH1A1 (0.50) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2
SCHEMBL1004649 0.80 ALDH1A1 (0.73) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL505778 0.79 ALDH1A1 (0.55) HSD11B1ALDH1A1HPGDSMN1; SMN2EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12551570-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2026-02-17 — — US disclosed
US-12479927-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2025-11-25 — — US disclosed
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF INTOCELL, INC. (KR) 2025-07-03 — — US disclosed
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates INTOCELL, INC. (KR) 2025-04-15 — — US disclosed
EP-4452328-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF Intocell, Inc. (KR) 2024-10-30 — — EP disclosed
US-20230406877-A1 COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF INTOCELL, INC. (KR) 2023-12-21 — — US disclosed
US-11807628-B2 Benzodiazepine derivatives and uses thereof INTOCELL, INC. (KR) 2023-11-07 — — US disclosed
US-11753431-B2 Compounds comprising cleavable linker and uses thereof INTOCELL, INC. (KR) 2023-09-12 — — US disclosed
WO-2023118961-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF INTOCELL, INC. (KR) 2023-06-29 — — WO disclosed
US-20230190939-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF INTOCELL, INC. (KR) 2023-06-22 — — US disclosed
WO-2008061032-A1 OPTICAL DATA RECORDING AND IMAGING ON MEDIA USING APOCHROMATIC LENSES HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2008-05-22 — — WO disclosed
WO-2008061030-A1 OPTICAL DATA RECORDING AND IMAGING ON MEDIA USING APOCHROMATIC LENSES AND A LIGHT SEPARATING MEANS HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2008-05-22 — — WO disclosed
US-20080050672-A1 LIGHT ACTIVATED CONTRAST SYSTEMS USING MASKED DEVELOPERS FOR OPTICAL DATA RECORDING HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. 2008-02-28 — — US disclosed
WO-2008024984-A1 LIGHT ACTIVATED CONTRAST SYSTEMS USING MASKED DEVELOPERS FOR OPTICAL DATA RECORDING HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2008-02-28 — — WO disclosed
US-20070265296-A1 Nuclear receptor binding agents GTX, INC. 2007-11-15 — — US disclosed
WO-2007062230-A2 NUCLEAR RECEPTOR BINDING AGENTS GTX, INC. (US) 2007-05-31 — — WO disclosed
US-20050254551-A1 Temperature monitoring system HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. 2005-11-17 — — US disclosed
US-6958181-B1 Protected activators for use in leuco dye compositions HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2005-10-25 — — US disclosed
US-20050227034-A1 PROTECTED ACTIVATORS FOR USE IN LEUCO DYE COMPOSITIONS HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. 2005-10-13 — — US disclosed
WO-2005025885-A1 PROTECTED ACTIVATORS FOR USE IN LEUCO DYE COMPOSITIONS HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) 2005-03-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230190939-A1 ANTIBODY DRUG CONJUGATES COMPRISING TOXINS WITH POLAR GROUPS AND USES THEREOF CD47, ENPP2, CD2 HSD11B1 3801/4885ALDH1A1 4468/4885HPGD 4281/4885
US-11807628-B2 Benzodiazepine derivatives and uses thereof GABRB3, GABRB2, GABRB1 HSD11B1 735/4885ALDH1A1 900/4885HPGD 471/4885
US-20250213712-A1 ANTIBODY DRUG CONJUGATES COMPRISING CAMPTOTHECIN DERIVATIVES AND USES THEREOF CD47, TOP2A, SSB HSD11B1 3855/4885ALDH1A1 2732/4885HPGD 1599/4885
US-12551570-B2 Compounds comprising cleavable linker and uses thereof FCGR2A, FCGR3B, FCGR1A HSD11B1 4306/4885ALDH1A1 4586/4885HPGD 4856/4885
US-20070265296-A1 Nuclear receptor binding agents GPER1, ESRRG, ESR2 HSD11B1 272/4885ALDH1A1 3644/4885HPGD 1070/4885
US-20230406877-A1 COMPOUNDS COMPRISING CLEAVABLE LINKER AND USES THEREOF VIP, ANTXR2, TNFRSF9 HSD11B1 4588/4885ALDH1A1 4822/4885HPGD 2968/4885
US-12479927-B2 Compounds comprising cleavable linker and uses thereof VIP, ANTXR2, TNFRSF9 HSD11B1 4588/4885ALDH1A1 4822/4885HPGD 2968/4885
US-11753431-B2 Compounds comprising cleavable linker and uses thereof VIP, ANTXR2, TNFRSF9 HSD11B1 4588/4885ALDH1A1 4822/4885HPGD 2968/4885
US-12274898-B2 Substituted benzodiazepines as antibody-drug conjugates GABRA3, GABRA6, GABRA4 HSD11B1 668/4885ALDH1A1 207/4885HPGD 2221/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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