Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.56 |
| ▸ | PDE7A known ✓ | Q13946 | 1/20 | 0.46 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.50 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.50 |
| ▸ | ITGAL | P20701 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30461057 | 1.00 | CYP3A4 (0.94) | CYP3A4TSHRCA1CA2ITGB2 | |
| Hydrochloric Acid SCHEMBL4372371 | 1.00 | CYP3A4 (0.94) | CYP3A4TSHRCA1CA2ITGB2 | |
| SCHEMBL29417504 | 0.97 | — | — | |
| SCHEMBL203854 | 0.97 | — | — | |
| Iodide SCHEMBL31415573 | 0.94 | CYP3A4 (0.94) | CYP3A4TSHRCA1CA2ITGB2 | |
| Bromide SCHEMBL10782798 | 0.94 | CYP3A4 (0.94) | CYP3A4TSHRCA1CA2ITGB2 | |
| Methane SCHEMBL22289636 | 0.94 | CYP3A4 (0.94) | CYP3A4TSHRCA1CA2ITGB2 | |
| Nitrogen SCHEMBL28338057 | 0.92 | CYP3A4 (0.89) | CYP3A4TSHRCA1CA2ITGB2 | |
| 1,2-Dichlorobenzene SCHEMBL28179689 | 0.89 | CYP3A4 (0.84) | CYP3A4TSHRCA1CA2MAPT | |
| SCHEMBL28180435 | 0.85 | CYP3A4 (0.76) | CYP3A4TSHRCA1CA2ITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112358419-B | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-115448863-A | Continuous preparation process of 3, 4-dichlorophenyl thiourea | 浙江迪邦化工有限公司 | 2022-12-09 | — | — | CN | claimed |
| CN-112358419-A | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2021-02-12 | — | — | CN | claimed |
| US-4409386-A | Separation of 3,4-dichloroaniline | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-10-11 | — | — | US | claimed |
| CN-112358419-B | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-112358419-B | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-115634635-A | Preparation device and preparation method of high-purity granular 2,5-dichloroaniline | 江苏瑞祥化工有限公司 | 2023-01-24 | — | — | CN | disclosed |
| CN-115448863-A | Continuous preparation process of 3, 4-dichlorophenyl thiourea | 浙江迪邦化工有限公司 | 2022-12-09 | — | — | CN | disclosed |
| CN-112358419-A | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2021-02-12 | — | — | CN | disclosed |
| CN-112358419-A | Synthesis process of 3, 4-dichlorophenyl isocyanate | 浙江丽水有邦新材料有限公司 | 2021-02-12 | — | — | CN | disclosed |
| CN-112011194-A | Disperse dye composition, preparation method thereof and treatment method of dye intermediate of disperse dye composition | 浙江闰土研究院有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-106833023-B | Disperse dye composition and preparation method and application thereof | 浙江闰土研究院有限公司 | 2020-05-01 | — | — | CN | disclosed |
| US-4225617-A | PSYCHOTROPIC AGENTS | LABORATOIRE L. LAFON (FR) | 1980-09-30 | — | — | US | disclosed |
| US-4210451-A | Regenerated cellulose flameproofed with organophosphorylamides | SANDOZ LTD. (CH) | 1980-07-01 | — | — | US | disclosed |
| US-4209524-A | CENTRAL NERVOUS SYSTEM | LABORATOIRE L. LAFON (FR) | 1980-06-24 | — | — | US | disclosed |
| US-4209523-A | TREATMENT OF THE CENTRAL NERVOUS SYSTEM | LABORATOIRE L. LAFON (FR) | 1980-06-24 | — | — | US | disclosed |
| US-4183951-A | PSYCHOTROPIC AGENTS | LABORATOIRE L. LAFON (FR) | 1980-01-15 | — | — | US | disclosed |
| US-4152458-A | CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC AGENTS | LABORATOIRE L. LAFON (FR) | 1979-05-01 | — | — | US | disclosed |
| US-4151300-A | CENTRAL NERVOUS SYSTEM, PSYCHOTROPIC | LABORATOIRE L. LAFON (FR) | 1979-04-24 | — | — | US | disclosed |
| US-4122186-A | PSYCHOTROPIC AGENTS | LABORATOIRE L. LAFON (FR) | 1978-10-24 | — | — | US | disclosed |