Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.70 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.66 |
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.65 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.65 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.65 |
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | CA5A | P35218 | 1/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.65 |
| ▸ | F2 | P00734 | 3/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.59 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8975904 | 1.00 | KMT2A (0.70) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL6525363 | 0.98 | KMT2A (0.72) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL33350 | 0.98 | KMT2A (0.72) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL33351 | 0.98 | KMT2A (0.72) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL9471995 | 0.98 | KMT2A (0.72) | KMT2AGAAHTTCA2CA5A | |
| Nitrogen SCHEMBL4382159 | 0.96 | KMT2A (0.66) | KMT2AGAAHTTCA2CA5A | |
| Ammonia Solution, Strong SCHEMBL9479957 | 0.96 | KMT2A (0.70) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL10474225 | 0.96 | KMT2A (0.70) | KMT2AGAAHTTCA2CA5A | |
| SCHEMBL4579511 | 0.96 | KMT2A (0.70) | KMT2AGAAHTTCA2CA5A | |
| Water SCHEMBL8747065 | 0.96 | KMT2A (0.70) | KMT2AGAAHTTCA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109415312-A | Alkylation | 通用电气健康护理有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-106456632-A | Methods of inhibiting necroptosis | 催化剂治疗私人有限公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-0609025-B1 | Process for producing optically active epoxy alcohol derivatives | ARCO CHEM TECH (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5436370-A | From nitrobenzene, chlorosulfonic acid, thionyl chloride | HOECHST AG (DE) | 1995-07-25 | — | — | US | disclosed |
| EP-0609025-A1 | Process for producing optically active epoxy alcohol derivatives | ARCO Chemical Technology, L.P. (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5252759-A | Reacting with organic sulfonyl halide to produce organic sulfonate | ARCO CHEMICAL TECHNOLOGY, L.P. (US) | 1993-10-12 | — | — | US | disclosed |
| US-5086128-A | HIGH MOLECULAR WEIGHT ARYLENE SULPHIDE POLYMER MELT MIXED WITH AROMATIC NITRO COMPOUND | BAYER AKTIENGESELLSCHAFT (DE) | 1992-02-04 | — | — | US | disclosed |
| WO-1991013863-A1 | METHOD FOR PREPARING 3-NITROBENZENE SULPHONIC ACID CHLORIDE | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-09-19 | — | — | WO | disclosed |
| US-4656290-A | Process for preparing thio, dithio or carbonyl compounds | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1987-04-07 | — | — | US | disclosed |
| US-4587275-A | AROMATIC DIAMINE WITH SULFONIC ACID GROUP AS CHAIN EXTENSION AGENT | BAYER AKTIENGESELLSCHAFT (DE) | 1986-05-06 | — | — | US | disclosed |
| US-4388246-A | THERMAL SPLITTING OF CARBAMATES | BAYER AKTIENGESELLSCHAFT (DE) | 1983-06-14 | — | — | US | disclosed |
| US-4368260-A | Photographic light sensitive element | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1983-01-11 | — | — | US | disclosed |
| US-4195992-A | AZO DYE | AGFA-GEVAERT AKTIENGESELLSCHAFT (DE) | 1980-04-01 | — | — | US | disclosed |