Dimethylamine

Dimethylamine

SCHEMBL907685

CCC[Mg+2].CNC.Cl

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Dimethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL4224813 0.96
Dimethylamine SCHEMBL11617039 0.92
Diethylamine SCHEMBL11281613 0.77 TP53 (0.57)
Butane SCHEMBL28158603 0.77
Methyl Alcohol SCHEMBL1993580 0.73
Propane SCHEMBL10466038 0.71
Butane SCHEMBL3052765 0.71
Propane SCHEMBL28102545 0.71 KDM4E (0.40)
Propane SCHEMBL28102546 0.71
Alcohol SCHEMBL1992680 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080119662-A1 One Spot Synthesis of Citalopram from 5-Cyanophthalide JUBILANT ORGANOSYS LIMTED (IN) 2008-05-22 US claimed
EP-1723133-A1 ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE Jubilant Organosys Limited (IN) 2006-11-22 EP claimed
WO-2005077927-A1 ONE POT SYNTHESIS OF CITALOPRAM FROM 5-CYANOPHTHALIDE JUBILANT ORGANOSYS LIMITED (IN) 2005-08-25 WO claimed
WO-2004065375-A1 PROCESSES FOR THE PREPARATION OF ESCITALOPRAM AND ITS PRECURSOR NATCO PHARMA LIMITED (IN) 2004-08-05 WO claimed
US-20160207942-A1 METHOD FOR PRODUCING ALKYL-INDIUM COMPOUNDS AND THE USE THEREOF UMICORE AG & CO. KG (DE) 2016-07-21 US disclosed
US-8288569-B2 Carbonyl asymmetric alkylation SANDOZ AG (CH) 2012-10-16 US disclosed
EP-1966127-B1 CARBONYL ASYMMETRIC ALKYLATION SANDOZ AG (CH) 2011-04-06 EP disclosed
US-20110009648-A1 Carbonyl Asymmetric Alkylation SANDOZ AG (CH) 2011-01-13 US disclosed
US-7767840-B2 Organometallic compounds ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2010-08-03 US disclosed
US-20090156852-A1 Organometallic compounds ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2009-06-18 US disclosed
EP-1682526-B1 METHOD FOR THE PREPARATION OF CITALOPRAM ADORKEM TECHNOLOGY SPA (IT) 2009-01-14 EP disclosed
EP-1464724-B1 Organometallic germanium compounds suitable for use in vapor deposition processes ROHM & HAAS ELECT MAT (US) 2008-12-10 EP disclosed
US-6579993-B2 Halogenating 5-cyanophthalide to a cyanobenzeneacyl halide derivative reacted with organometallic 4-fluorophenyl halides and 4-fluorophenylboranes to a biphenyl ketone reacted with an organometallic 3-dimethylaminopropyl halide ORION CORPORATION, FERMION (FI) 2003-06-17 US disclosed
EP-1288211-A1 Improved process for the manufacture of citalopram hydrobromide from 5-bromophthalide Sekhsaria Chemicals Ltd. (IN) 2003-03-05 EP disclosed
WO-2002066453-A1 PROCESS FOR THE PREPARATION OF CITALOPRAM NATCO PHARMA LIMITED (IN) 2002-08-29 WO disclosed
US-20020115872-A1 Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-Fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile ORION CORPORATION FERMION (FI) 2002-08-22 US disclosed
WO-2002060886-A1 PROCESS FOR THE PREPARATION OF 1-(3-DIMETHYLAMINOPROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE ORION CORPORATION, FERMION (FI) 2002-08-08 WO disclosed
US-4235820-A Process for dibenzocycloheptene compounds MERCK & CO., INC. (US) 1980-11-25 US disclosed
US-4113726-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1978-09-12 US disclosed
US-3984419-A HYPOTENSIVES E. R. SQUIBB & SONS, INC. (US) 1976-10-05 US disclosed