Hydrochloric Acid

Hydrochloric Acid

SCHEMBL9800501

Cl.NC(C(=O)Cl)c1ccccc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SRC known ✓ P12931 1/20 0.44
DPP4 known ✓ P27487 2/20 0.44
CYP2D6 P10635 1/20 0.44
F2 P00734 1/20 0.44
ALDH1A1 P00352 1/20 0.43
LMNA P02545 2/20 0.43
MAPK1 P28482 1/20 0.43
CTSD P07339 1/20 0.42
CES2 O00748 1/20 0.41
CES1 P23141 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2003210 1.00 CYP2D6 (0.44) CYP2D6SRCDPP4F2ALDH1A1
Hydrochloric Acid SCHEMBL6718139 1.00 CYP2D6 (0.44) CYP2D6SRCDPP4F2ALDH1A1
SCHEMBL8481256 0.98 CYP2D6 (0.46) CYP2D6SRCDPP4F2LMNA
SCHEMBL10932246 0.98 CYP2D6 (0.46) CYP2D6SRCDPP4F2LMNA
SCHEMBL2594496 0.98 CYP2D6 (0.46) CYP2D6SRCDPP4F2LMNA
Phenylglycine SCHEMBL2003211 0.81 CYP2D6 (0.54) CYP2D6SRCDPP4F2ALDH1A1
Phenylglycine SCHEMBL6718142 0.81 CYP2D6 (0.54) CYP2D6SRCDPP4F2ALDH1A1
Phenylglycine SCHEMBL4431879 0.81 CYP2D6 (0.54) CYP2D6SRCDPP4F2ALDH1A1
Phenylglycine SCHEMBL540378 0.81 CYP2D6 (0.54) CYP2D6SRCDPP4F2ALDH1A1
Phenylglycine SCHEMBL304109 0.81 CYP2D6 (0.54) CYP2D6SRCDPP4F2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4310458-A PRODUCTION OF AMOXYCILLIN AND AMPICILLIN BRISTOL-MYERS COMPANY (US) 1982-01-12 US claimed
US-4139702-A Process for preparing cephalosporines DOBFAR S.P.A. (IT) 1979-02-13 US claimed
US-4127571-A Process for preparing penicillins DOBFAR S.P.A. (IT) 1978-11-28 US claimed
CN-1095846-C Production process of cephem compound EISAI KAGAKU KK (JP) 2002-12-11 CN disclosed
CN-1184814-A Production process of cephem compound EISAI KAGAKU KK (JP) 1998-06-17 CN disclosed
US-5034522-A Silating, acylation, basification and solvent extraction BIOCRAFT LABORATORIES, INC. (US) 1991-07-23 US disclosed
EP-0108545-B1 PROCESS AND INTERMEDIATES FOR PREPARATION OF 1,1-DIOXOPENICILLANOYLOXYMETHYL 6-BETA-AMINOPENICILLANATE PFIZER INC. (US) 1986-12-17 EP disclosed
US-4530792-A Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate PFIZER INC. (US) 1985-07-23 US disclosed
EP-0108545-A1 Process and intermediates for preparation of 1,1-dioxopenicillanoyloxymethyl 6-beta-aminopenicillanate PFIZER INC. (US) 1984-05-16 EP disclosed
EP-0097489-A1 Process and intermediates for 6'-aminopenicillanoyloxymethyl penicillanate 1,1-dioxide PFIZER INC. (US) 1984-01-04 EP disclosed
US-4375434-A Process for 6'-amino-penicillanoyloxymethyl penicillanate 1,1-dioxide PFIZER INC. (US) 1983-03-01 US disclosed
US-4092335-A ANTIBIOTICS OF LOW TOXICITY POLITECHNIKA GDANSKA (PO) 1978-05-30 US disclosed
US-4081455-A ANTIBACTERIAL PFIZER INC. (US) 1978-03-28 US disclosed
US-4077967-A 6-Substituted penicillanic acid and derivatives thereof E. R. SQUIBB & SONS, INC. (US) 1978-03-07 US disclosed
US-4066657-A ANTIBACTERIAL AGENTS FOR ANIMAL FEED SUPPLEMENTS PFIZER INC. (US) 1978-01-03 US disclosed
US-4036846-A ANTIBACTERIAL PFIZER INC. (US) 1977-07-19 US disclosed
US-4031077-A Antibacterial 3-phosphono penams PFIZER INC. (US) 1977-06-21 US disclosed
US-3996236-A ANTIBACTERIAL BRISTOL-MYERS COMPANY (US) 1976-12-07 US disclosed
US-3992394-A PENICILLIN INTERMEDIATES FOR BACTERICIDES PFIZER INC. (US) 1976-11-16 US disclosed
US-3985740-A THERAPEUTIC AND ANTIBACTERIAL AGENTS BRISTOL-MYERS COMPANY (US) 1976-10-12 US disclosed