Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 3/20 | 0.33 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38638 | 0.97 | RECQL (0.41) | RECQLGAAALDH1A1L3MBTL1ATM | |
| Water SCHEMBL27364346 | 0.94 | RECQL (0.40) | RECQLGAAALDH1A1L3MBTL1POLB | |
| SCHEMBL29829607 | 0.94 | RECQL (0.40) | RECQLGAAALDH1A1L3MBTL1POLB | |
| SCHEMBL30728078 | 0.94 | RECQL (0.40) | RECQLGAAALDH1A1L3MBTL1POLB | |
| Ammonia Solution, Strong SCHEMBL27500860 | 0.94 | RECQL (0.40) | RECQLGAAALDH1A1L3MBTL1POLB | |
| Ammonia Solution, Strong SCHEMBL27280766 | 0.92 | RECQL (0.39) | RECQLGAAALDH1A1POLB | |
| Hno SCHEMBL8563343 | 0.89 | RECQL (0.38) | RECQLGAAALDH1A1L3MBTL1ATM | |
| Alcohol SCHEMBL75326 | 0.87 | RECQL (0.36) | RECQLGAAALDH1A1POLBMEN1 | |
| SCHEMBL27936322 | 0.85 | RECQL (0.35) | RECQLGAAALDH1A1POLBMEN1 | |
| Propene SCHEMBL5919675 | 0.85 | GAA (0.40) | RECQLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7862746-B2 | Stabilization of natural composites | BASF SE. (DE) | 2011-01-04 | — | — | US | claimed |
| WO-2006087269-A1 | STABILIZATION OF NATURAL COMPOSITES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-08-24 | — | — | WO | claimed |
| US-20060183821-A1 | Stabilization of natural composites | CIBA CORPORATION | 2006-08-17 | — | — | US | claimed |
| US-7862746-B2 | Stabilization of natural composites | BASF SE. (DE) | 2011-01-04 | — | — | US | disclosed |
| WO-2006087269-A1 | STABILIZATION OF NATURAL COMPOSITES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-08-24 | — | — | WO | disclosed |
| US-20060183821-A1 | Stabilization of natural composites | CIBA CORPORATION | 2006-08-17 | — | — | US | disclosed |
| US-5496875-A | Derivatives of 2,2,6,6-tetramethyl-4-piperidinol for use as light stabilizers, heat stabilizers and oxidation stabilizers for organic materials | CIBA-GEIGY CORPORATION (US) | 1996-03-05 | — | — | US | disclosed |
| EP-0233476-B1 | PEROXIDE FREE RADICAL INITIATORS CONTAINING HINDERED AMINE LIGHT STABILIZER GROUPS | ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) | 1992-12-23 | — | — | EP | disclosed |
| US-4999392-A | Light, Heat and Oxidation Stabilizers for Polymers | CIBA-GEIGY CORPROATION (US) | 1991-03-12 | — | — | US | disclosed |
| EP-0377633-A4 | PEROXIDE FREE RADICAL INITIATORS CONTAINING HINDERED AMINE LIGHT STABILIZER GROUPS | — | 1991-01-30 | — | — | EP | disclosed |
| EP-0377633-A1 | PEROXIDE FREE RADICAL INITIATORS CONTAINING HINDERED AMINE LIGHT STABILIZER GROUPS. | PENNWALT CORP (US) | 1990-07-18 | — | — | EP | disclosed |
| EP-0377197-A1 | 4-(2'-Ethyl hexanoyloxy)-2,2,6,6-tetramethyl piperidine and its use | BASF Aktiengesellschaft (DE) | 1990-07-11 | — | — | EP | disclosed |
| US-4925903-A | PEROXIDE CONTAINING HINDERED AMINE ALSO FUNCTIONS AS INITIATOR | PENNWALT CORPORATION (US) | 1990-05-15 | — | — | US | disclosed |
| US-4885347-A | UNSATURATED POLYESTER | PENNWALT CORPORATION (US) | 1989-12-05 | — | — | US | disclosed |
| EP-0315204-A2 | Bleaching composition | LION CORPORATION (JP) | 1989-05-10 | — | — | EP | disclosed |
| US-4822883-A | 2,2,6,6-TETRA SUBSTITUTED PIPERIDIN-4-YL PEROXY DERIVATIVES BECOMING CHEMICALLY BONDED TO ADDITION POLYMER | PENNWALT CORPORATION (US) | 1989-04-18 | — | — | US | disclosed |
| WO-1989001474-A1 | PEROXIDE FREE RADICAL INITIATORS CONTAINING HINDERED AMINE LIGHT STABILIZER GROUPS | PENNWALT CORPORATION (US) | 1989-02-23 | — | — | WO | disclosed |
| US-4780493-A | STABILIZERS AGAINST LIGHT, HEAT OR OXIDATION | CIBA-GEIGY CORPORATION (US) | 1988-10-25 | — | — | US | disclosed |
| EP-0233476-A2 | Peroxide free radical initiators containing hindered amine light stabilizer groups | ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) | 1987-08-26 | — | — | EP | disclosed |