SCHEMBL988439

SCHEMBL988439

C=C(C(=O)OC(C)(C)C)S(=O)(=O)C(C)(C)C

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.31
CA12 O43570 2/20 0.30
CA14 Q9ULX7 2/20 0.30
CA1 P00915 1/20 0.30
CA7 P43166 1/20 0.30
CA2 P00918 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL988462 0.80 ALDH1A1 (0.42)
SCHEMBL988483 0.80 DGAT1 (0.32) DGAT1CA12CA14CA1CA7
SCHEMBL1173666 0.80 DGAT1 (0.32) DGAT1CA12CA14CA1CA7
SCHEMBL3691901 0.74 DGAT1 (0.31) DGAT1CA12CA14CA1CA7
SCHEMBL3968260 0.72 TET2 (0.33)
SCHEMBL2712242 0.71 DGAT1 (0.39) DGAT1
SCHEMBL78520 0.69 DGAT1 (0.46) DGAT1CA12CA14CA1CA7
SCHEMBL8398362 0.69 DGAT1 (0.37) DGAT1
SCHEMBL3896600 0.69 DGAT1 (0.37) DGAT1
SCHEMBL33412 0.69 ALDH1A1 (0.50) DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1792889-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2015-03-04 EP claimed
US-7741511-B2 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-22 US claimed
US-20060085922-A1 Oxidizing composition comprising at least one electrophilic monomer and at least one non-benzoquinone oxidant L'OREAL S.A. (FR) 2006-04-27 US claimed
US-20120156270-A1 METHOD FOR SMOOTHING OUT THE SKIN BY FILLING IN RECESSED PORTIONS L'OREAL (FR) 2012-06-21 US disclosed
US-20120156270-A1 METHOD FOR SMOOTHING OUT THE SKIN BY FILLING IN RECESSED PORTIONS L'OREAL (FR) 2012-06-21 US disclosed
EP-2451536-A2 METHOD FOR SMOOTHING OUT THE SKIN BY FILLING IN RECESSED PORTIONS L'Oréal (FR) 2012-05-16 EP disclosed
WO-2011003771-A2 METHOD FOR SMOOTHING OUT THE SKIN BY FILLING IN RECESSED PORTIONS L'OREAL (FR) 2011-01-13 WO disclosed
US-20100172858-A1 COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER L'OREAL S.A. (FR) 2010-07-08 US disclosed
US-7741511-B2 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-22 US disclosed
EP-2124874-A2 COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER L'Oreal (FR) 2009-12-02 EP disclosed
US-7621966-B2 Cosmetic composition comprising at least one pigment and/or at least one filler surface-treated beforehand with at least one organic agent and at least one electrophilic monomer L'OREAL S.A. (FR) 2009-11-24 US disclosed
US-20060110334-A1 Two-compartment aerosol device comprising electrophilic monomers, and use thereof for the cosmetic treatment of the hair L'OREAL S.A. (FR) 2006-05-25 US disclosed
US-20060088493-A1 Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers L'OREAL S.A. (FR) 2006-04-27 US disclosed
US-20060085922-A1 Oxidizing composition comprising at least one electrophilic monomer and at least one non-benzoquinone oxidant L'OREAL S.A. (FR) 2006-04-27 US disclosed
US-20060088488-A1 Dyeing composition comprising a mixture of at least one pigment and at least one electrophilic monomer L'OREAL S.A. (FR) 2006-04-27 US disclosed
US-20060083706-A1 Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060080792-A1 Film-forming composition for the cosmetic treatment of keratin materials comprising at least one electrophilic monomer and at least one non-silicone polymer L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060083762-A1 Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles L'OREAL S.A. (FR) 2006-04-20 US disclosed
US-20060078523-A1 Composition comprising at least one electrophilic monomer and at least one acid in a cosmetically acceptable anhydrous medium, and use thereof for cosmetic treatment of the hair L'OREAL S.A. (FR) 2006-04-13 US disclosed
US-20060078522-A1 Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt L'OREAL S.A. (FR) 2006-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060110334-A1 Two-compartment aerosol device comprising electrophilic monomers, and use thereof for the cosmetic treatment of the hair POLR1C, TRPA1, GSTM2 DGAT1 445/4885CA12 3511/4885CA14 4063/4885
US-20060088493-A1 Composition and process for the cosmetic treatment of keratin materials based on electrophilic monomers and non-silicone polymers KRT18, CUTA, MARK1 DGAT1 1639/4885CA12 3395/4885CA14 2409/4885
US-20060083762-A1 Uses of compositions comprising electrophilic monomers and micro-particles or nanoparticles KRT18, PRKDC, ACP1 DGAT1 2105/4885CA12 1912/4885CA14 1603/4885
US-20100172858-A1 COSMETIC COMPOSITION COMPRISING AT LEAST ONE POLYMER OBTAINED FROM A DIELECTROPHILIC MONOMER KRT18, DSG1, DSC1 DGAT1 328/4885CA12 796/4885CA14 861/4885
US-20060085922-A1 Oxidizing composition comprising at least one electrophilic monomer and at least one non-benzoquinone oxidant KRT18, GPX4, NOX4 DGAT1 2308/4885CA12 4311/4885CA14 4323/4885
US-20060083706-A1 Haircare composition comprising at least one electrophilic monomer and micro- or nanoparticles of at least one solid lubricant MITF, CUTA, NACA DGAT1 853/4885CA12 3938/4885CA14 3566/4885
US-20060078523-A1 Composition comprising at least one electrophilic monomer and at least one acid in a cosmetically acceptable anhydrous medium, and use thereof for cosmetic treatment of the hair HOGA1, OAT, SUCLG1 DGAT1 367/4885CA12 705/4885CA14 772/4885
US-20060088488-A1 Dyeing composition comprising a mixture of at least one pigment and at least one electrophilic monomer KRT18, IK, DDR1 DGAT1 3923/4885CA12 1535/4885CA14 880/4885
US-20060078522-A1 Composition for treating keratin materials comprising at least one electrophilic monomer and at least one salt KRT18, DSG1, DSC1 DGAT1 1614/4885CA12 720/4885CA14 356/4885
US-20120156270-A1 METHOD FOR SMOOTHING OUT THE SKIN BY FILLING IN RECESSED PORTIONS EPAS1, PGF, PASK DGAT1 2879/4885CA12 3488/4885CA14 3567/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.