Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251108 | 0.75 | TRPA1 (0.30) | MEN1POLBKMT2A | |
| SCHEMBL7839459 | 0.75 | MEN1 (0.30) | MEN1POLBKMT2A | |
| SCHEMBL11648239 | 0.75 | AKR1C1 (0.32) | MEN1POLBKMT2A | |
| SCHEMBL10937384 | 0.75 | MEN1 (0.30) | MEN1POLBKMT2A | |
| SCHEMBL28060933 | 0.71 | DPP4 (0.40) | — | |
| SCHEMBL9270158 | 0.71 | — | — | |
| SCHEMBL6536454 | 0.71 | ALDH1A1 (0.31) | — | |
| SCHEMBL8087905 | 0.71 | — | — | |
| SCHEMBL3258571 | 0.71 | MEN1 (0.31) | MEN1POLBKMT2A | |
| SCHEMBL27866604 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106471002-B | Process for producing siloxanes from basic salts of silanols | 瓦克化学股份公司 | 2019-05-10 | — | — | CN | disclosed |
| CN-106471002-A | Process for producing siloxanes from basic salts of silanols | 瓦克化学股份公司 | 2017-03-01 | — | — | CN | disclosed |
| EP-2155761-B1 | MULTI-FUNCTIONAL SILSESQUIOXANES FOR NOVEL COATING APPLICATIONS | MAYATERIALS INC (US) | 2013-08-14 | — | — | EP | disclosed |
| US-7868198-B2 | Multi-functional silsesquioxanes for novel coating applications | LAINE, RICHARD M | 2011-01-11 | — | — | US | disclosed |
| EP-2155761-A2 | MULTI-FUNCTIONAL SILSESQUIOXANES FOR NOVEL COATING APPLICATIONS | Mayaterials, Inc. (US) | 2010-02-24 | — | — | EP | disclosed |
| US-20090012317-A1 | Multi-functional silsesquioxanes for novel coating applications | MAYATERIALS, INC. (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2009002660-A2 | MULTI-FUNCTIONAL SILSESQUIOXANES FOR NOVEL COATING APPLICATIONS | MAYATERIALS, INC. (US) | 2008-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012317-A1 | Multi-functional silsesquioxanes for novel coating applications | OSBPL8, SPEN, SFXN3 | MEN1 2492/4885POLB 3507/4885KMT2A 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.