Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19142282 | 0.82 | CYP11B1 (0.36) | NOS3NOS1NOS2NPC1HSP90AA1 | |
| SCHEMBL4183808 | 0.75 | LMNA (0.30) | — | |
| SCHEMBL14339844 | 0.75 | CHRM2 (0.31) | — | |
| SCHEMBL9694568 | 0.73 | GAA (0.38) | NPC1PDCD1CD274ALDH1A1 | |
| SCHEMBL18996011 | 0.71 | — | — | |
| SCHEMBL47849 | 0.67 | NOS3 (0.43) | NOS3NOS1NOS2NPC1ALDH1A1 | |
| SCHEMBL134931 | 0.67 | CYP1A2 (0.34) | NPC1HSP90AA1L3MBTL1 | |
| SCHEMBL4340785 | 0.67 | TSHR (0.32) | NOS3NOS1NOS2 | |
| SCHEMBL28857380 | 0.67 | HRH1 (0.34) | NOS3NOS1NOS2 | |
| SCHEMBL18996006 | 0.67 | GABRG2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357239-A1 | PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230145793-A1 | SUBSTITUTED PYRIMIDINE OR PYRIDINE AMINE DERIVATIVE, COMPOSITION THEREOF, AND MEDICAL USE THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-05-11 | — | — | US | disclosed |
| US-20180093958-A1 | POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC PRODUCT | ZEON CORPORATION (JP) | 2018-04-05 | — | — | US | disclosed |
| US-20180079906-A1 | AZACYANINE DYES AND USE THEREOF | Ecole polytechnique fédérale de Lausanne (EPFL) (CH) | 2018-03-22 | — | — | US | disclosed |
| US-9868710-B2 | Polymerizable compound, polymerizable composition, polymer, and optically anisotropic product | ZEON CORPORATION (JP) | 2018-01-16 | — | — | US | disclosed |
| US-20170174678-A1 | NOVEL ANTIVIRAL COMPOUNDS AND METHODS USING SAME | Rhe Trustees of The University of Pennsylvania | 2017-06-22 | — | — | US | disclosed |
| EP-2912464-B1 | HYDROXAMATE SUBSTITUTED AZAINDOLINE-CYANINE DYES AND BIOCONJUGATES OF THE SAME | BECTON DICKINSON CO (US) | 2017-04-26 | — | — | EP | disclosed |
| US-9580409-B2 | Modulators of opioid receptors and methods of use thereof | SUNOVION PHARMACEUTICALS, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160257659-A1 | POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC PRODUCT | ZEON CORPORATION (JP) | 2016-09-08 | — | — | US | disclosed |
| US-20120040430-A1 | Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-20110183962-A1 | SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS | NOVARTIS AG (CH) | 2011-07-28 | — | — | US | disclosed |
| US-20110059941-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B] PYRIDINE/PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100093004-A1 | Autophagy and phospholipidosis pathway assays | ENZO LIFE SCIENCES, INC. | 2010-04-15 | — | — | US | disclosed |
| US-20100041663-A1 | Organic Compounds as Smo Inhibitors | NOVARTIS AG | 2010-02-18 | — | — | US | disclosed |
| US-20100041020-A1 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | ENZO LIFE SCIENCES, INC. | 2009-09-10 | — | — | US | disclosed |
| US-7569695-B2 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20070299091-A1 | Azaindole Carboxamides | GMEINER PETER | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183962-A1 | SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS | GLI1, SHH, SMO | NOS3 2674/4885NOS1 3470/4885NOS2 2918/4885 |
| US-20070299091-A1 | Azaindole Carboxamides | TPH1, TPH2, HTR1A | NOS3 2077/4885NOS1 1438/4885NOS2 1258/4885 |
| US-20160257659-A1 | POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC PRODUCT | CCNA1, PYM1, SCO2 | NOS3 1696/4885NOS1 976/4885NOS2 1576/4885 |
| US-20090226954-A1 | Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits | SSBP1, IMMT, DNAJA3 | NOS3 3772/4885NOS1 4056/4885NOS2 4122/4885 |
| US-20170174678-A1 | NOVEL ANTIVIRAL COMPOUNDS AND METHODS USING SAME | ZC3HAV1, MAVS, ZC3HAV1L | NOS3 3590/4885NOS1 3979/4885NOS2 3924/4885 |
| US-20230357239-A1 | PYRIDO[2,3-D]PYRIMIDIN-4-AMINES AS SOS1 INHIBITORS | SOS1, PPM1D, SOS2 | NOS3 1820/4885NOS1 445/4885NOS2 1649/4885 |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | NOS3 2338/4885NOS1 2118/4885NOS2 3134/4885 |
| US-20100041663-A1 | Organic Compounds as Smo Inhibitors | SMO, GLI1, SHH | NOS3 340/4885NOS1 214/4885NOS2 293/4885 |
| US-20110059941-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B] PYRIDINE/PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | GCK, PDXK, GCKR | NOS3 1285/4885NOS1 2326/4885NOS2 1545/4885 |
| US-20230145793-A1 | SUBSTITUTED PYRIMIDINE OR PYRIDINE AMINE DERIVATIVE, COMPOSITION THEREOF, AND MEDICAL USE THEREOF | ADORA2A, ADORA2B, ADORA3 | NOS3 1959/4885NOS1 2407/4885NOS2 1974/4885 |
| US-20180079906-A1 | AZACYANINE DYES AND USE THEREOF | INMT, AZI2, MYADM | NOS3 642/4885NOS1 655/4885NOS2 511/4885 |
| US-20180093958-A1 | POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, AND OPTICALLY ANISOTROPIC PRODUCT | CCNA2, CCNB2, CCNA1 | NOS3 2016/4885NOS1 1320/4885NOS2 951/4885 |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ANXA5, POLRMT, DCLRE1B | NOS3 3793/4885NOS1 4146/4885NOS2 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.