Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrogallol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.92 |
| ▸ | EGFR known ✓ | P00533 | 2/20 | 0.92 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.92 |
| ▸ | PIK3CA known ✓ | P42336 | 1/20 | 0.53 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.92 |
| ▸ | HPGD | P15428 | 4/20 | 0.92 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.92 |
| ▸ | LMNA | P02545 | 3/20 | 0.92 |
| ▸ | RECQL | P46063 | 3/20 | 0.92 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.92 |
| ▸ | FYN | P06241 | 2/20 | 0.92 |
| ▸ | MMP9 | P14780 | 2/20 | 0.92 |
| ▸ | CA1 | P00915 | 2/20 | 0.92 |
| ▸ | CDK2 | P24941 | 2/20 | 0.92 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.92 |
| ▸ | MMP2 | P08253 | 1/20 | 0.92 |
| ▸ | CA6 | P23280 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrogallol SCHEMBL27513761 | 1.00 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL3532 | 0.96 | — | — | |
| Pyrogallol SCHEMBL170157 | 0.96 | ALDH1A1 (1.00) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL1042997 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL6270291 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL11661058 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL10986410 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL11324823 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL3778541 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA | |
| Pyrogallol SCHEMBL4884788 | 0.92 | ALDH1A1 (0.92) | ALDH1A1HPGDALOX15HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118955948-A | Chitosan hydrogel with photo-thermal and active oxygen removing functions and preparation method thereof | 武汉大学中南医院 | 2024-11-15 | — | — | CN | disclosed |
| CN-116083306-B | MRS improved culture medium for plant lactobacillus and culture optimization method and application thereof | 广州栋方生物科技股份有限公司 | 2024-11-08 | — | — | CN | disclosed |
| CN-114452370-B | Use of Ma Gusui enzymolysis peptide in preparation of preparation for preventing osteoporosis | 新疆农业大学 | 2024-06-11 | — | — | CN | disclosed |
| CN-117617490-A | Preparation method of composite ferment capable of reducing loss of active substances in processing process and obtained product | 青岛博恩高科生物技术有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-117426449-A | Processing method of roxburgh rose fruit juice | 西南大学 | 2024-01-23 | — | — | CN | disclosed |
| CN-117180167-A | Mask essence, mask and preparation method of mask essence | 贵州理工学院 | 2023-12-08 | — | — | CN | disclosed |
| CN-115948292-B | Lactobacillus reuteri strain A21041 with anti-inflammatory and antioxidant functions and application thereof | 广西爱生生命科技有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-114601175-B | Preparation method of enteric sustained-release high-activity glutathione nano-microsphere | 六安益普罗科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-115896048-B | Recombinant human Cu, zn-SOD with high enzyme activity and good stability, and preparation method and application thereof | 河北纳科生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116083306-A | MRS improved culture medium for plant lactobacillus and culture optimization method and application thereof | 广州栋方生物科技股份有限公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-104342408-A | Preparation method of recombinant cordyceps sinensis superoxide dismutase (rcSOD) | JILIN JINZIYUAN BIOLOG SCIENCE & TECHNOLOGY CO LTD | 2015-02-11 | — | — | CN | disclosed |
| CN-103585096-A | Essence with functions of activating and tightening skin and preparation method thereof | LIU AN DANHUANG BIOTECHNOLOGY CO LTD | 2014-02-19 | — | — | CN | disclosed |
| CN-102993320-A | Isolates of radix hedysari polysaccharide 3 and application thereof | UNIV LANGZHOU | 2013-03-27 | — | — | CN | disclosed |
| CN-101732379-B | Process for gathering and purifying panax japonicus total saponins by using D101 macroporous absorption resin | FARM PRODUCT PROC & NUCLEAR AGRICULTURAL TECH INST HUBEI AAS | 2012-08-29 | — | — | CN | disclosed |
| CN-102090989-B | Application of phellodendron polysaccharide in resisting ultraviolet radiation and preparation method of ultraviolet-resistant sun-screening agent thereof | PLA THE MILITARY GENERAL HOSPITAL BEIJING | 2012-05-23 | — | — | CN | disclosed |
| CN-102085160-B | Application of coptis chinensis polysaccharides for resisting ultraviolet radiation and preparation method of anti-ultraviolet sun-screening agent | CHINA PLA GENERAL HOSPITAL | 2012-02-15 | — | — | CN | disclosed |
| CN-102090989-A | Application of phellodendron polysaccharides for resisting ultraviolet radiation and preparation method of anti-ultraviolet sun-screening agent | MILITARY REGION GENERAL HOSPITAL OF BEJING PLA | 2011-06-15 | — | — | CN | disclosed |
| CN-102085160-A | Application of coptis chinensis polysaccharides for resisting ultraviolet radiation and preparation method of anti-ultraviolet sun-screening agent | PLA BEIJING MILITARY REGION GENERAL HOSPITAL | 2011-06-08 | — | — | CN | disclosed |
| CN-101732379-A | Process for gathering and purifying panax japonicus total saponins by using D101 macroporous absorption resin | FARM PRODUCT PROC AND NUCLEAR | 2010-06-16 | — | — | CN | disclosed |
| US-3936573-A | Microcapsule having hydrophilic wall material and containing water soluble core material | NCR CORPORATION (US) | 1976-02-03 | — | — | US | disclosed |