Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 known ✓ | P51681 | 3/20 | 0.89 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.89 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.89 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.89 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.56 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.56 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.56 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.47 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 5/20 | 0.89 |
| ▸ | CCR8 | P51685 | 5/20 | 0.89 |
| ▸ | LMNA | P02545 | 4/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.89 |
| ▸ | MMP2 | P08253 | 2/20 | 0.89 |
| ▸ | TSHR | P16473 | 2/20 | 0.89 |
| ▸ | MAPT | P10636 | 2/20 | 0.89 |
| ▸ | HTT | P42858 | 2/20 | 0.89 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.89 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.89 |
| ▸ | GMNN | O75496 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL5461212 | 0.97 | CCR1 (0.84) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL28973442 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29367240 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL5347299 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL7268958 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL725644 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL1681332 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29401908 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL345410 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL31040598 | 0.97 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6256368-A | — | — | None | — | — | JP | disclosed |
| US-7961315-B2 | Fluorescence detection enhancement using photonic crystal extraction | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-06-14 | — | — | US | disclosed |
| US-20110031409-A1 | Fluorescence detection enhancement using photonic crystal extraction | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2011-02-10 | — | — | US | disclosed |
| US-7768640-B2 | Fluorescence detection enhancement using photonic crystal extraction | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-08-03 | — | — | US | disclosed |
| US-20100055666-A1 | BIOSENSOR WITH EVANESCENT WAVEGUIDE AND INTEGRATED SENSOR | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2010-03-04 | — | — | US | disclosed |
| EP-2137529-A1 | CALIBRATION AND NORMALIZATION METHOD FOR BIOSENSORS | SRU Biosystems, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| EP-2115433-A1 | BIOSENSOR WITH EVANESCENT WAVEGUIDE AND INTEGRATED SENSOR | Koninklijke Philips Electronics N.V. (NL) | 2009-11-11 | — | — | EP | disclosed |
| US-7558446-B2 | All polymer optical waveguide sensor | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2009-07-07 | — | — | US | disclosed |
| US-20080278722-A1 | Fluorescence detection enhancement using photonic crystal extraction | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2008-11-13 | — | — | US | disclosed |
| WO-2008136812-A2 | FLUORESCENCE DETECTION ENHANCEMENT USING PHOTONIC CRYSTAL EXTRACTION | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2008-11-13 | — | — | WO | disclosed |
| US-20060051830-A1 | Quantitation of enzyme activity using planar waveguides | BAYER HEALTHCARE LLC | 2006-03-09 | — | — | US | disclosed |
| EP-0760944-B1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | NOVARTIS AG (CH) | 2002-04-17 | — | — | EP | disclosed |
| US-5959292-A | Process for detecting evanescently excited luminescence | NOVARTIS CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0759159-B1 | PROCESS AND SENSOR FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | CIBA GEIGY AG (CH) | 1998-10-14 | — | — | EP | disclosed |
| US-5822472-A | Process for detecting evanescently excited luminescence | NOVARTIS CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| EP-0760944-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | Novartis AG (CH) | 1997-03-12 | — | — | EP | disclosed |
| EP-0759159-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | Novartis AG (CH) | 1997-02-26 | — | — | EP | disclosed |
| WO-1995033197-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | CIBA-GEIGY AG (CH) | 1995-12-07 | — | — | WO | disclosed |
| WO-1995033198-A1 | PROCESS FOR DETECTING EVANESCENTLY EXCITED LUMINESCENCE | CIBA-GEIGY AG (CH) | 1995-12-07 | — | — | WO | disclosed |
| JP-H06256368-A | PRODUCTION OF TRIS(1,10-PHENANTHROLINE) RUTHENIUM CHLORIDE | TANAKA KIKINZOKU KOGYO KK | 1994-09-13 | — | — | JP | disclosed |