Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenanthroline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 known ✓ | P51681 | 3/20 | 0.94 |
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.94 |
| ▸ | MMP8 known ✓ | P22894 | 1/20 | 0.94 |
| ▸ | MMP13 known ✓ | P45452 | 1/20 | 0.94 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.58 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.58 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.58 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.48 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.48 |
| ▸ | CCR1 | P32246 | 5/20 | 0.94 |
| ▸ | CCR8 | P51685 | 5/20 | 0.94 |
| ▸ | LMNA | P02545 | 4/20 | 0.94 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.94 |
| ▸ | MMP2 | P08253 | 2/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | MAPT | P10636 | 2/20 | 0.94 |
| ▸ | HTT | P42858 | 2/20 | 0.94 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.94 |
| ▸ | GMNN | O75496 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenanthroline SCHEMBL4901390 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL31040598 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL28973442 | 1.00 | CCR1 (0.94) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL30165588 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8324317 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL996092 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL1237620 | 0.97 | CCR1 (0.89) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29354015 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL29367277 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E | |
| Phenanthroline SCHEMBL8845760 | 0.97 | CCR1 (1.00) | CCR1CCR8LMNACCR5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111218270-A | Preparation method of modified time-resolved fluorescent microspheres | 长沙美牛生物科技有限公司 | 2020-06-02 | — | — | CN | claimed |
| CN-110010912-A | A kind of catalyst of fuel cell and its preparation method and application | 中国石油大学(北京) | 2019-07-12 | — | — | CN | claimed |
| US-9970121-B2 | Composite material, method for forming the composite material, electrode plated with the composite material, and connection structure having the composite material | DENSO CORPORATION (JP) | 2018-05-15 | — | — | US | claimed |
| CN-104588003-B | A kind of heterogeneous metal catalyst and its application in isobutanol is prepared by methanol and ethanol water | 中国科学院青岛生物能源与过程研究所 | 2017-11-07 | — | — | CN | claimed |
| US-20160201211-A1 | COMPOSITE MATERIAL, METHOD FOR FORMING THE COMPOSITE MATERIAL, ELECTRODE PLATED WITH THE COMPOSITE MATERIAL, AND CONNECTION STRUCTURE HAVING THE COMPOSITE MATERIAL | DENSO CORPORATION (JP) | 2016-07-14 | — | — | US | claimed |
| CN-102276604-A | Preparation method of o-phenanthroline hydrochloride | — | 2011-12-14 | — | — | CN | claimed |
| EP-2237029-A1 | Pumping electrode of gas sensor, method of manufacturing conductive paste, and gas sensor | NGK Insulators, Ltd. (JP) | 2010-10-06 | — | — | EP | claimed |
| US-20100243447-A1 | PUMPING ELECTRODE OF GAS SENSOR, METHOD OF MANUFACTURING CONDUCTIVE PASTE, AND GAS SENSOR | NGK INSULATORS, LTD. (JP) | 2010-09-30 | — | — | US | claimed |
| US-20080300133-A1 | Oxygen Scavenger/Indicator | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) | 2008-12-04 | — | — | US | claimed |
| CN-119997942-A | Compounds for the treatment of cancer | 埃维克斯塔生物公司 | 2025-05-13 | — | — | CN | disclosed |
| CN-119463850-A | Silicon-coated color fluorescent microsphere and mild preparation method and application thereof | 南京理工大学 | 2025-02-18 | — | — | CN | disclosed |
| CN-117186872-B | Method for preparing color time-resolved fluorescent microsphere by one-step method | 南京立顶医疗科技有限公司 | 2024-05-10 | — | — | CN | disclosed |
| WO-2024075780-A1 | METHOD FOR CULTURING DEHALOCOCCOIDES GENUS BACTERIA AND METHOD FOR PURIFYING CHLORINATED ETHYLENES | 株式会社テクノスルガ・ラボ | 2024-04-11 | — | — | WO | disclosed |
| CN-116585530-B | Chloroplast composite hydrogel capable of efficiently producing oxygen and preparation method and application thereof | 暨南大学 | 2024-02-02 | — | — | CN | disclosed |
| WO-1989003434-A1 | SUPPORTED HETEROPOLYCYCLIC COMPOUNDS IN THE SEPARATION AND REMOVAL OF LATE TRANSITION METALS | MACEDO, PEDRO, B. (US) | 1989-04-20 | — | — | WO | disclosed |
| EP-0078544-A1 | Reagent and process for the detection of a critical water content in hydraulic fluids, especially brake fluids | LUCAS INDUSTRIES public limited company (GB) | 1983-05-11 | — | — | EP | disclosed |
| EP-0040722-B1 | PROCESS FOR THE PREPARATION OF SYNTHETIC LEPIDOCROCITE | BASF Aktiengesellschaft (DE) | 1983-03-23 | — | — | EP | disclosed |
| EP-0040722-A1 | Process for the preparation of synthetic lepidocrocite | BASF Aktiengesellschaft (DE) | 1981-12-02 | — | — | EP | disclosed |
| US-4275031-A | A CUVETTE WITH REAGENT EMBEDDED IN A CLEAR POLYMER COATING | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-06-23 | — | — | US | disclosed |
| US-3978096-A | Production of 1-chloroanthraquinone | BASF AKTIENGESELLSCHAFT (DT) | 1976-08-31 | — | — | US | disclosed |