Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | CD81 | P60033 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL11169491 | 1.00 | GRIK1 (0.35) | GRIK1GRIK2CD81PTGS1AKR1C3 | |
| Trimethylammonium SCHEMBL136534 | 1.00 | GRIK1 (0.35) | GRIK1GRIK2CD81PTGS1AKR1C3 | |
| Trimethylammonium SCHEMBL1469277 | 0.98 | GRIK1 (0.36) | GRIK1GRIK2CD81PTGS1AKR1C3 | |
| Trimethylammonium SCHEMBL679439 | 0.98 | GRIK1 (0.36) | GRIK1GRIK2CD81PTGS1AKR1C3 | |
| Trimethylammonium SCHEMBL27571825 | 0.95 | GRIK1 (0.35) | GRIK1GRIK2CD81PTGS1AKR1C3 | |
| Hydrochloric Acid SCHEMBL2564983 | 0.93 | — | — | |
| SCHEMBL17819 | 0.90 | — | — | |
| SCHEMBL17817 | 0.90 | — | — | |
| SCHEMBL5716965 | 0.90 | — | — | |
| N,N-Dimethylethanaminium SCHEMBL11902174 | 0.88 | GRIK1 (0.34) | GRIK1GRIK2CD81PTGS1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060013785-A1 | Hairstyling gels with light protective action for skin and hair | WELLA AG (DE) | 2006-01-19 | — | — | US | claimed |
| CN-112739446-A | Monovalent selective cation exchange membranes | 懿华水处理技术有限责任公司 | 2021-04-30 | — | — | CN | disclosed |
| US-20170224604-A1 | CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME | EVONIK DEGUSSA GMBH (DE) | 2017-08-10 | — | — | US | disclosed |
| US-9561452-B2 | Process and apparatus for treating drilling fluid | ZEIDLER H UDO (CA) | 2017-02-07 | — | — | US | disclosed |
| US-20150336030-A1 | PROCESS AND APPARATUS FOR TREATING DRILLING FLUID | ZEIDLER H UDO (CA) | 2015-11-26 | — | — | US | disclosed |
| EP-2558510-B1 | CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME | AIR PROD & CHEM (US) | 2015-05-20 | — | — | EP | disclosed |
| WO-2014127477-A1 | PROCESS AND APPARATUS FOR TREATING DRILLING FLUID | ZEIDLER H UDO (CA) | 2014-08-28 | — | — | WO | disclosed |
| US-20140220704-A1 | ARTICLES COMPRISING TEMPLATED CROSSLINKED POLYMER FILMS FOR ELECTRONIC DETECTION OF NITROAROMATIC EXPLOSIVES | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2013066456-A2 | ARTICLES COMPRISING TEMPLATED CROSSLINKED POLYMER FILMS FOR ELECTRONIC DETECTION OF NITROAROMATIC EXPLOSIVES | THE JOHNS HOPKINS UNIVERSITY (US) | 2013-05-10 | — | — | WO | disclosed |
| US-20120184044-A1 | MOLECULARLY-IMPRINTED POLYMERIC MATERIALS FOR VISUAL DETECTION OF EXPLOSIVES | RAPTOR DETECTION, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| EP-0706399-A4 | COMPOSITIONS AND PROCESS FOR REMOVING BILE SALTS | GELTEX PHARMA INC (US) | 1998-08-12 | — | — | EP | disclosed |
| EP-0706399-A1 | COMPOSITIONS AND PROCESS FOR REMOVING BILE SALTS | GELTEX PHARMACEUTICALS, INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| WO-1994027620-A1 | COMPOSITIONS AND PROCESS FOR REMOVING BILE SALTS | GELTEX PHARMACEUTICALS, INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| US-5316772-A | Bilayered oral pharmaceutical composition with pH dependent release | SOLVAY & CIE, S.A. (SOCIETE ANONYME) (BE) | 1994-05-31 | — | — | US | disclosed |
| WO-1992011001-A1 | ORAL PHARMACEUTICAL COMPOSITION | SOLVAY (SOCIETE ANONYME) (BE) | 1992-07-09 | — | — | WO | disclosed |
| EP-0192183-A2 | Weakly cross-linked polymers or copolymers in the form of particles and quickly swellable in water, method for making them and their use in hygienic articles | RÖHM GMBH (DE) | 1986-08-27 | — | — | EP | disclosed |
| US-4367297-A | Water-soluble poly(meth)acrylic acid derivatives gels and their manufacture | CHEMISCHE FABRIK STOCKHAUSEN GMBH (DE) | 1983-01-04 | — | — | US | disclosed |
| US-4217209-A | Process for removing heavy metal sulphides from aqueous systems | BAYER AKTIENGESELLSCHAFT (DE) | 1980-08-12 | — | — | US | disclosed |
| US-4208309-A | ACRYLAMIDE POLYMERS | ROHM GMBH (DE) | 1980-06-17 | — | — | US | disclosed |
| US-4190713-A | CARRIERS FOR BIOLOGICALLY ACTIVE MATERIALS | ROHM GMBH (DE) | 1980-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170224604-A1 | CATIONIC/CATIONOGENIC COMB COPOLYMER COMPOSITIONS AND PERSONAL CARE PRODUCTS CONTAINING THE SAME | C9, CUTA, ZYX | PTGS1 3205/4885GRIK1 1703/4885GRIK2 2420/4885 |
| US-20060013785-A1 | Hairstyling gels with light protective action for skin and hair | SUCLG1, CUTA, MTCL3 | PTGS1 1208/4885GRIK1 1978/4885GRIK2 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.