Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.40 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.40 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362855 | 0.99 | CA12 (0.43) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL29430364 | 0.99 | CA12 (0.43) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL24621959 | 0.93 | CA12 (0.44) | CA12CA1CA9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11350984 | 0.88 | CA1 (0.46) | CA12CA1CA9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL29692762 | 0.88 | CA1 (0.49) | CA12CA1CA9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11482111 | 0.88 | CA12 (0.45) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL11350787 | 0.88 | KDM4E (0.46) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL31301807 | 0.88 | KDM4E (0.46) | CA12CA1CA9KDM4EALDH1A1 | |
| SCHEMBL29544027 | 0.87 | CA1 (0.50) | CA12CA1CA9KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL11470385 | 0.86 | CA1 (0.50) | CA12CA1CA9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643475-B1 | ANALYSIS OF DIRECT FACTOR XA INHIBITORS | DOASENSE GMBH (DE) | 2018-01-03 | — | — | EP | claimed |
| US-9810701-B2 | Analysis of direct factor Xa inhibitors | DOASENSE GMBH (DE) | 2017-11-07 | — | — | US | claimed |
| US-20160011218-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | DOASENSE GMBH (DE) | 2016-01-14 | — | — | US | claimed |
| US-20150344935-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | DOASENSE GMBH (DE) | 2015-12-03 | — | — | US | claimed |
| US-9133501-B2 | Analysis of direct factor Xa inhibitors | Ruprecht-Karls-Universität Heidelberg (DE) | 2015-09-15 | — | — | US | claimed |
| US-20130302839-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | UNIVERSITAT HEIDELBERG (DE) | 2013-11-14 | — | — | US | claimed |
| EP-3460070-A1 | IMPROVED DETECTION OF ANTICOAGULANTS IN BODY FLUIDS | DOASENSE GmbH (DE) | 2019-03-27 | — | — | EP | disclosed |
| US-9897617-B2 | Analysis of direct factor Xa inhibitors | DOASENSE GMBH (DE) | 2018-02-20 | — | — | US | disclosed |
| EP-2643475-B1 | ANALYSIS OF DIRECT FACTOR XA INHIBITORS | DOASENSE GMBH (DE) | 2018-01-03 | — | — | EP | disclosed |
| US-9810701-B2 | Analysis of direct factor Xa inhibitors | DOASENSE GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| US-20160011218-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | DOASENSE GMBH (DE) | 2016-01-14 | — | — | US | disclosed |
| US-20150344935-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | DOASENSE GMBH (DE) | 2015-12-03 | — | — | US | disclosed |
| US-9133501-B2 | Analysis of direct factor Xa inhibitors | Ruprecht-Karls-Universität Heidelberg (DE) | 2015-09-15 | — | — | US | disclosed |
| US-20130302839-A1 | ANALYSIS OF DIRECT FACTOR Xa INHIBITORS | UNIVERSITAT HEIDELBERG (DE) | 2013-11-14 | — | — | US | disclosed |