Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.49 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.49 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 0.49 |
| ▸ | OPRD1 known ✓ | P41143 | 3/20 | 0.49 |
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 0.49 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 7/20 | 0.47 |
| ▸ | EBP | Q15125 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988252 | 0.98 | KCNH2 (0.55) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL6658937 | 0.98 | KCNH2 (0.55) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL989475 | 0.92 | KCNH2 (0.64) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| Hydrochloric Acid SCHEMBL27850434 | 0.87 | KCNH2 (0.49) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| Hydrochloric Acid SCHEMBL27850433 | 0.87 | KCNH2 (0.49) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL9602480 | 0.85 | KCNH2 (0.50) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL27527563 | 0.85 | KCNH2 (0.50) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL9227248 | 0.85 | TAAR1 (0.48) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL9500849 | 0.83 | KCNH2 (0.47) | KCNH2DRD2OPRM1DRD3OPRD1 | |
| SCHEMBL855604 | 0.80 | KCNH2 (0.44) | KCNH2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313026-A1 | ACTIVE DELIVERY SYSTEM FORMULATIONS | Castle Beach, L.L.C. (US) | 2011-04-27 | — | — | EP | claimed |
| US-20100040565-A1 | ACTIVE DELIVERY SYSTEMS FORMULATIONS | Castle Beach, LLC (US) | 2010-02-18 | — | — | US | claimed |
| WO-2010019680-A1 | ACTIVE DELIVERY SYSTEM FORMULATIONS | HOMOLA ANDREW M (US) | 2010-02-18 | — | — | WO | claimed |
| EP-0805672-B1 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | HOMOLA ANDREW M (US) | 2004-08-25 | — | — | EP | claimed |
| EP-0959872-A4 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | FOUR STAR PARTNERS (US) | 2000-08-23 | — | — | EP | claimed |
| EP-0959872-A1 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | Four Star Partners (US) | 1999-12-01 | — | — | EP | claimed |
| US-5980868-A | A PROTECTIVE COATINGS COMPRISING A CATIONIC SURFACE ACTIVE AGENTS, HYDROPHOBIC BARRIER-FORMING MATERIALS AND ANTIMICROBIAL COMPOUNDS | PROVSEAL LLC | 1999-11-09 | — | — | US | claimed |
| WO-1998002136-A9 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | — | 1998-05-28 | — | — | WO | claimed |
| WO-1998002136-A1 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | HOMOLA ANDREW M (US) | 1998-01-22 | — | — | WO | claimed |
| EP-0554029-B1 | Oral compositions | SUNSTAR KK (JP) | 1995-09-20 | — | — | EP | claimed |
| US-5348738-A | With quaternary nitrogen atoms and, as stabilizer for the polymer, polyoxyethylene-polyoxypropylene block copolymer surfactant | SUNSTAR KABUSHIKI KAISHA (JP) | 1994-09-20 | — | — | US | claimed |
| EP-0554029-A1 | Oral compositions | SUNSTAR KABUSHIKI KAISHA (JP) | 1993-08-04 | — | — | EP | claimed |
| EP-2313026-A1 | ACTIVE DELIVERY SYSTEM FORMULATIONS | Castle Beach, L.L.C. (US) | 2011-04-27 | — | — | EP | disclosed |
| US-20100040565-A1 | ACTIVE DELIVERY SYSTEMS FORMULATIONS | Castle Beach, LLC (US) | 2010-02-18 | — | — | US | disclosed |
| WO-2010019680-A1 | ACTIVE DELIVERY SYSTEM FORMULATIONS | HOMOLA ANDREW M (US) | 2010-02-18 | — | — | WO | disclosed |
| EP-1365731-B1 | A CONTROLLED DELIVERY SYSTEM FOR HAIR CARE PRODUCTS | SALVONA LLC (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-1996022078-A1 | METHODS, COMPOSITIONS, AND DENTAL DELIVERY SYSTEMS FOR THE PROTECTION OF THE SURFACES OF TEETH | HOMOLA ANDREW M (US) | 1996-07-25 | — | — | WO | disclosed |
| EP-0554029-B1 | Oral compositions | SUNSTAR KK (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5348738-A | With quaternary nitrogen atoms and, as stabilizer for the polymer, polyoxyethylene-polyoxypropylene block copolymer surfactant | SUNSTAR KABUSHIKI KAISHA (JP) | 1994-09-20 | — | — | US | disclosed |
| EP-0554029-A1 | Oral compositions | SUNSTAR KABUSHIKI KAISHA (JP) | 1993-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100040565-A1 | ACTIVE DELIVERY SYSTEMS FORMULATIONS | LIPA, MMP7, CTSA | KCNH2 4825/4885DRD2 3610/4885OPRM1 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.