Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiamine Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | TKT | P29401 | 11/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamine Ion SCHEMBL7200449 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL258492 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL41101 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL1251742 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL5317564 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL30028012 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL16085815 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL18879464 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL18167436 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL28055245 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117897478-A | Novel microbial diamine oxidase derived from yarrowia lipolytica for biogenic amine degradation | 霍恩海姆大学 | 2024-04-16 | — | — | CN | disclosed |
| CN-115337283-A | Nano-encapsulation object for wrapping adenosine by molecular motor vesicle, preparation method thereof, composition and application of composition | 杭州优玛达生物科技有限公司 | 2022-11-15 | — | — | CN | disclosed |
| US-9243264-B2 | Production of methane | FFGF LIMITED (VG) | 2016-01-26 | — | — | US | disclosed |
| US-20150176030-A1 | PRODUCTION OF METHANE | FFGF LIMITED (VG) | 2015-06-25 | — | — | US | disclosed |
| US-8506953-B2 | Use and methods for preventing and/or treating oral malodour | BASF SE (DE) | 2013-08-13 | — | — | US | disclosed |
| EP-2442808-A2 | COMPOSITION FOR TRANSPORTING OROTIC ACID ACROSS THE BLOOD-BRAIN BARRIER | Werth Acupuncture Center S.L.U. (ES) | 2012-04-25 | — | — | EP | disclosed |
| US-20110097284-A1 | USE AND METHODS FOR PREVENTING AND/OR TREATING ORAL MALODOUR | BASF SE (DE) | 2011-04-28 | — | — | US | disclosed |
| WO-2010145644-A2 | COMPOSITION FOR TRANSPORTING OROTIC ACID ACROSS THE BLOOD-BRAIN BARRIER | WERTH ACUPUNCTURE CENTER S.L.U. (ES) | 2010-12-23 | — | — | WO | disclosed |
| EP-1712632-A2 | Gene for a heat resistant enzymes of the amino acid biosynthetic pathway derived from thermophilic Coryneform bacteria | Ajinomoto Co., Inc. (JP) | 2006-10-18 | — | — | EP | disclosed |
| EP-1268840-A2 | THAUERA STRAIN MZ1T EXOPOLYSACCHARIDES | EASTMAN CHEMICAL COMPANY (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001075138-A2 | THAUERA STRAIN MZ1T EXOPOLYSACHHARIDES | EASTMAN CHEMICAL COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |