Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thiamine Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 known ✓ | P07900 | 1/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | TKT | P29401 | 11/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiamine Ion SCHEMBL7200449 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL1644252 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL258492 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL1251742 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL5317564 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL30028012 | 1.00 | HSP90AA1 (0.95) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL16085815 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL18879464 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL18167436 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA | |
| Thiamine Ion SCHEMBL28055245 | 0.99 | HSP90AA1 (0.93) | HSP90AA1KDM4ETKTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 54458 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122074396-A | Method for rapid propagation of radix cynanchi bungei seedlings and seedling raising thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121379932-B | Culture medium for high-density serum-free suspension culture of BHK-21 cells and application thereof | Zhongsheng tianxinhe (Wuxi) Biotechnology Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122081234-A | Low-serum MSB1 suspension medium and chicken infectious anemia virus inactivated vaccine | — | 2026-05-26 | — | — | CN | claimed |
| CN-122074613-A | Bergamot effervescent tablet based on microencapsulation inclusion technology and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122060613-A | Preparation method of anaerobic microbial agent for stably degrading 1, 4-dichlorobenzene | 南京大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122039173-A | Acidic copper plating brightening agent, acidic copper plating electroplating solution and electroplating process thereof | 惠州金晟新电子科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-115820503-B | Preparation method of fecal bacteria for intestinal flora transplantation | 山东省大健康精准医疗产业技术研究院 | 2026-05-15 | — | — | CN | claimed |
| CN-119547727-B | Technology for shortening cotton breeding period and application | 河北农业大学 | 2026-05-15 | — | — | CN | claimed |
| CN-121555202-B | Microbial soil conditioner and preparation method and application thereof | 山东北游生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122012386-A | Cell culture medium for producing/preparing mesenchymal stem cell exosomes | 上海英浛思生物技术有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-0019054-A1 | Nutrient medium and its use in testing antimicrobial agents | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | claimed |
| US-4218492-A | FREE OF NITRATES, NITRITES, OR VEGETABLE BINDER | Micromatic, Inc. (US) | 1980-08-19 | — | — | US | claimed |
| US-4204366-A | Method of non-agricultural production of cotyledons | PURDUE RESEARCH FOUNDATION (US) | 1980-05-27 | — | — | US | claimed |
| US-4167562-A | Method and composition for treating arteriosclerosis | EVERS H RAY | 1979-09-11 | — | — | US | claimed |
| US-4081565-A | ADDING A MEAT ENZYMATIC DIGEST, AND A SULFUR COMPOUND | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-03-28 | — | — | US | claimed |
| US-4076852-A | MIXING CYSTEINE HYDROCHLORIDE, EGGS, THIAMINE HYDROCHLORIDE | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-02-28 | — | — | US | claimed |
| US-4048316-A | Composition for antagonizing the narcotic effects of barbiturate addiction and withdrawal effects, and for treatment of barbiturate poisoning | PENN NATHAR W | 1977-09-13 | — | — | US | claimed |
| US-4042733-A | Forming solid, adhesive-free composite of membrane filters and cellulosic cardboard | BOEHRINGER INGELHEIM GMBH (DT) | 1977-08-16 | — | — | US | claimed |
| US-3960670-A | Method and apparatus for sterility monitoring | PFLUG IRVING J | 1976-06-01 | — | — | US | claimed |
| US-3959509-A | Flavoring foodstuffs using sulfur-containing compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1976-05-25 | — | — | US | claimed |