Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12024914 | 0.89 | ACHE (0.48) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL19351217 | 0.89 | ACHE (0.43) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL10019863 | 0.87 | CYP3A4 (0.42) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL8254130 | 0.85 | TSHR (0.47) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL7833966 | 0.85 | ALDH1A1 (0.45) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL7843399 | 0.85 | TPMT (0.50) | ACHEMAPTCYP3A4CA9TP53 | |
| SCHEMBL26546786 | 0.84 | PDE4A (0.41) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL15249007 | 0.82 | PTGS2 (0.47) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL12809228 | 0.82 | ACHE (0.38) | ACHEMAPTCYP3A4CA9PTGS2 | |
| SCHEMBL19341804 | 0.82 | ACHE (0.42) | ACHEMAPTCYP3A4CA9PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 253 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230332243-A1 | PATIENT SELECTION BIOMARKERS FOR TREATMENT WITH ULK INHIBITORS | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2023-10-19 | — | — | US | disclosed |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | UNIVERSITÉ DE MONCTON (CA) | 2023-09-19 | — | — | US | disclosed |
| US-20230219942-A1 | COMPOUNDS COMPRISING A THREE RING CORE AS PD-1/PD-L1 BLOCKERS | RELIVE THERAPEUTICS INC. (CA) | 2023-07-13 | — | — | US | disclosed |
| US-20230130766-A1 | MONO AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS | SALK INSTITUTE FOR BIOLOGICAL STUDIES | 2023-04-27 | — | — | US | disclosed |
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
| US-20230025301-A1 | Novel Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases | TONGJI UNIVERSITY (CN) | 2023-01-26 | — | — | US | disclosed |
| US-20230020507-A1 | COMPOUND AND USE THEREOF IN TREATING AUTOIMMUNE DISEASES | PARENCHYMA BIOTECH INC. (KR) | 2023-01-19 | — | — | US | disclosed |
| WO-2022119928-A1 | IMIDAZOLE COMPOUNDS AS INHIBITORS OF ENPP1 | Stingray Therapeutics, Inc. (US) | 2022-06-09 | — | — | WO | disclosed |
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | CELGENE CAR LLC (BM) | 2022-06-07 | — | — | US | disclosed |
| US-11332471-B2 | Leveling agent, metal plating composition containing same, preparation method therefor and use thereof | SHANGHAI SINYANG SEMICONDUCTOR MATERIALS CO., LTD. (CN) | 2022-05-17 | — | — | US | disclosed |
| US-7282608-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2007-10-16 | — | — | US | disclosed |
| US-7279469-B2 | Diaminotriazoles useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-09 | — | — | US | disclosed |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | METHYLGENE INC. (CA) | 2007-09-13 | — | — | US | disclosed |
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| WO-2007073383-A1 | NOVEL COMPOUNDS AND METHODS FOR FORMING TAXANES AND USING THE SAME | TAPESTRY PHARMACEUTICALS, INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| US-7230132-B2 | Aryl N-cyanoguanidines and methods related thereto | MIGENIX CORP. (US) | 2007-06-12 | — | — | US | disclosed |
| US-7217712-B2 | 4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3 inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-15 | — | — | US | disclosed |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
| US-20040082578-A1 | Arylindenopyridines and related therapeutic and prophylactic methods | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025301-A1 | Novel Heterocyclic Derivatives with Cardiomyocyte Proliferation Activity for Treatment of Heart Diseases | TNNI3, TNNT2, MKI67 | ACHE 4394/4885MAPT 4785/4885CYP3A4 2277/4885 |
| US-11760715-B2 | Modulators of lipoxygenase and cyclooxygenase enzyme activity | ALOX12, ALOX15B, ALOX5 | ACHE 724/4885MAPT 4792/4885CYP3A4 410/4885 |
| US-20040082578-A1 | Arylindenopyridines and related therapeutic and prophylactic methods | ADORA2A, ADORA1, PDE2A | ACHE 398/4885MAPT 4577/4885CYP3A4 1127/4885 |
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | ACHE 3309/4885MAPT 845/4885CYP3A4 2539/4885 |
| US-20070213330-A1 | Anticancer agents; antiproliferative agents | HDAC1, HDAC11, HDAC5 | ACHE 3428/4885MAPT 3612/4885CYP3A4 4595/4885 |
| US-20230130766-A1 | MONO AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS | ULK1, ULK2, ULK3 | ACHE 4884/4885MAPT 912/4885CYP3A4 4282/4885 |
| US-11351168-B1 | 2,4-disubstituted pyrimidines useful as kinase inhibitors | DCK, CDK2, DTYMK | ACHE 4707/4885MAPT 3269/4885CYP3A4 2948/4885 |
| US-20230332243-A1 | PATIENT SELECTION BIOMARKERS FOR TREATMENT WITH ULK INHIBITORS | ULK2, ULK1, ULK3 | ACHE 4874/4885MAPT 2110/4885CYP3A4 3787/4885 |
| US-11332471-B2 | Leveling agent, metal plating composition containing same, preparation method therefor and use thereof | PRPF8, CACNA1F, ATP1B2 | ACHE 2954/4885MAPT 2766/4885CYP3A4 4374/4885 |
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | ACHE 2837/4885MAPT 448/4885CYP3A4 1798/4885 |
| US-20230219942-A1 | COMPOUNDS COMPRISING A THREE RING CORE AS PD-1/PD-L1 BLOCKERS | CD274, PDCD1, PDCD1LG2 | ACHE 4390/4885MAPT 1976/4885CYP3A4 1942/4885 |
| US-20230020507-A1 | COMPOUND AND USE THEREOF IN TREATING AUTOIMMUNE DISEASES | VIP, BACH1, IL17A | ACHE 1526/4885MAPT 3697/4885CYP3A4 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.