Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA known ✓ | P06280 | 2/20 | 0.94 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.94 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.62 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.54 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.94 |
| ▸ | HPGD | P15428 | 3/20 | 0.94 |
| ▸ | NQO2 | P16083 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.54 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL30257128 | 1.00 | MAPT (0.94) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL96928 | 1.00 | MAPT (0.94) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL28062881 | 0.97 | MAPT (0.88) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL4972293 | 0.97 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL3045498 | 0.97 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL8339 | 0.97 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL1772714 | 0.97 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL29352289 | 0.97 | ALDH1A1 (1.00) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL1551975 | 0.94 | ALDH1A1 (0.94) | MAPTALDH1A1HPGDGLAACHE | |
| Acridine SCHEMBL2401648 | 0.94 | ALDH1A1 (0.94) | MAPTALDH1A1HPGDGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119104733-A | Serum amyloid A detection reagent and detection method based on improved spatial proximity chemiluminescence method | 无锡壹闪生物科技有限公司 | 2024-12-10 | — | — | CN | claimed |
| CN-114874116-A | Preparation method of thiosulfonate | 苏州照固新材料科技有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-114835674-A | Preparation method of aromatic thioether | 苏州照固新材料科技有限公司 | 2022-08-02 | — | — | CN | claimed |
| CN-113125227-A | Autumn aqueous solution for preparing high-resolution chromosome for karyotype analysis and application | 上海乐辰生物科技有限公司 | 2021-07-16 | — | — | CN | claimed |
| CN-109232589-B | Fluorescent probe and preparation and application thereof | 贵州大学 | 2021-04-06 | — | — | CN | claimed |
| CN-109232589-A | Fluorescent probe and preparation and application thereof | 贵州大学 | 2019-01-18 | — | — | CN | claimed |
| CN-105418501-B | 7 pairs of anisidino- benzo [c] acridine hydrochlorides and its preparation method and application | 广西中医药大学 | 2018-04-17 | — | — | CN | claimed |
| CN-105399671-B | 7 p-totuidine base benzo [c] acridine hydrochlorides and its preparation method and application | 广西中医药大学 | 2018-04-17 | — | — | CN | claimed |
| CN-107142300-A | A kind of Listeria enriched medium and preparation method | 中国疾病预防控制中心传染病预防控制所 | 2017-09-08 | — | — | CN | claimed |
| US-20070026130-A1 | Method of developing latent fingerprints | ARMOR HOLDINGS FORENSICS, INC. | 2007-02-01 | — | — | US | claimed |
| EP-0058591-B1 | EPIMERISATION OF TRANS CHRYSANTHEMIC ACIDS AND INTERMEDIATES OBTAINED THEREFROM | ROUSSEL-UCLAF (FR) | 1984-10-03 | — | — | EP | claimed |
| US-4447637-A | Epimerization of trans chrysanthemates | ROUSSEL UCLAF (FR) | 1984-05-08 | — | — | US | claimed |
| CN-119657220-A | Application of acridine yellow as catalyst in TMB oxidation color reaction | 甘肃政法大学 | 2025-03-21 | — | — | CN | disclosed |
| CN-119569654-A | 9-Aminoacridine compound with multi-electron-withdrawing substituent, and preparation method and application thereof | 郑州大学 | 2025-03-07 | — | — | CN | disclosed |
| CN-119104733-A | Serum amyloid A detection reagent and detection method based on improved spatial proximity chemiluminescence method | 无锡壹闪生物科技有限公司 | 2024-12-10 | — | — | CN | disclosed |
| US-20240150569-A1 | 2K-System | XETOS AG (DE) | 2024-05-09 | — | — | US | disclosed |
| US-4328210-A | Modified Pasteurella bacteria and vaccines prepared therefrom | NORDEN LABORATORIES, INC. (US) | 1982-05-04 | — | — | US | disclosed |
| EP-0036995-A1 | Veterinary vaccines for pasteurellosis | NORDEN LABORATORIES, INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4293545-A | IMMUNOLOGY | NORDEN LABORATORIES, INC. (US) | 1981-10-06 | — | — | US | disclosed |
| US-3971952-A | Method of detecting abnormal behavior of mammalian cells | YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) | 1976-07-27 | — | — | US | disclosed |