Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.59 |
| ▸ | HTR6 known ✓ | P50406 | 2/20 | 0.51 |
| ▸ | BCHE known ✓ | P06276 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | CA12 | O43570 | 2/20 | 0.96 |
| ▸ | CA4 | P22748 | 2/20 | 0.96 |
| ▸ | CA7 | P43166 | 2/20 | 0.96 |
| ▸ | CA9 | Q16790 | 2/20 | 0.96 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.96 |
| ▸ | CA3 | P07451 | 1/20 | 0.96 |
| ▸ | CA6 | P23280 | 1/20 | 0.96 |
| ▸ | CA5A | P35218 | 1/20 | 0.96 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | IDO1 | P14902 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL336183 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL29352235 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL28436110 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL8749395 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL10896568 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL29462545 | 1.00 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Bromide SCHEMBL11308965 | 0.98 | ALDH1A1 (0.96) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| SCHEMBL233681 | 0.98 | CA12 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| SCHEMBL29634851 | 0.98 | CA12 (1.00) | ALDH1A1TSHRHSD17B10RECQLCA12 | |
| Hydrochloric Acid SCHEMBL11308962 | 0.96 | ALDH1A1 (0.93) | ALDH1A1TSHRHSD17B10RECQLCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1963 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12491169-B1 | 1-naphthalenyl aminoethyl Schiff base and use as a death ligand-1 inhibitor | IMAM MOHAMMAD IBN SAUD ISLAMIC UNIVERSITY (SA) | 2025-12-09 | — | — | US | claimed |
| CN-119147485-A | Method for measuring nitrate nitrogen content and test pipeline | 中国热带农业科学院橡胶研究所 | 2024-12-17 | — | — | CN | claimed |
| EP-2997360-B1 | DISPOSABLE AND DISPERSIBLE EXPLOSIVE DETECTION DEVICE AND METHOD OF SIMULTANEOUS DETECTION OF EXPLOSIVES | THE DIRECTOR GENERAL DEFENCE RES & DEVELOPMENT ORGANISATION DRDO (IN) | 2024-07-24 | — | — | EP | claimed |
| CN-118275363-A | Method and device for online measurement of concentration of atmospheric nitric acid | 中国科学院化学研究所 | 2024-07-02 | — | — | CN | claimed |
| CN-118130183-A | Device for collecting gas to be detected, method for measuring nitrite concentration and method for obtaining soil HONO gas emission flux and/or concentration | 华东师范大学 | 2024-06-04 | — | — | CN | claimed |
| CN-114494175-B | Interactive space segmentation method for mass spectrum imaging data | 厦门大学 | 2024-05-03 | — | — | CN | claimed |
| CN-117563688-A | Three-dimensional paper chip, preparation method thereof and application thereof in nitrite detection | 广东环凯微生物科技有限公司 | 2024-02-20 | — | — | CN | claimed |
| CN-112098503-B | Method for in-vivo lipid three-dimensional mass spectrometry imaging based on integral zebra fish model | 广东工业大学 | 2023-11-21 | — | — | CN | claimed |
| US-20230349872-A1 | GUN SHOT RESIDUE FIELD KIT | VERITEQUE USA, INC. | 2023-11-02 | — | — | US | claimed |
| CN-116907952-A | Preparation method of matrix-assisted laser desorption ionization mass spectrometry imaging sample | 香港浸会大学深圳研究院 | 2023-10-20 | — | — | CN | claimed |
| US-20020066885-A1 | Stabilized liquid crystal alignment structure with pre-tilt angle and display devices containing the same | 3M INNOVATIVE PROPERTIES COMPANY | 2002-06-06 | — | — | US | claimed |
| WO-2001064842-A1 | A NOVEL OBLIGATELY SYMBIOTIC THERMOPHILE SYMBIOBACTERIUM TOEBII SC-1 PRODUCING THERMOSTABLE L-TYROSINE PHENOL-LYASE AND L-TRYPTOPHAN INDOLE-LYASE AND A METHOD FOR SCREENING ITS RELATIVE BACTERIA | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2001-09-07 | — | — | WO | claimed |
| US-5175089-A | Quantitative analysis | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1992-12-29 | — | — | US | claimed |
| US-5096812-A | Assay method for gamma glutamyltransferase (GGT) in liquid blood and dried blood | OSBORN LABORATORIES, INC. (US) | 1992-03-17 | — | — | US | claimed |
| EP-0380627-A4 | METHOD FOR MONITORING PERIODONTAL DISEASE BY MONITORING ENDOTOXINS AND INFLAMMATORY AGENTS | — | 1991-01-02 | — | — | EP | claimed |
| EP-0380627-A1 | METHOD FOR MONITORING PERIODONTAL DISEASE BY MONITORING ENDOTOXINS AND INFLAMMATORY AGENTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 1990-08-08 | — | — | EP | claimed |
| WO-1990000620-A1 | METHOD FOR MONITORING PERIODONTAL DISEASE BY MONITORING ENDOTOXINS AND INFLAMMATORY AGENTS | THE TRUSTEES OF COLUMBIA UNIVERSITY (US) | 1990-01-25 | — | — | WO | claimed |
| US-4812413-A | Reagent, process and kit for drug detection | EREZ FORENSIC TECHNOLOGY, LTD. (IL) | 1989-03-14 | — | — | US | claimed |
| US-4474888-A | Determination of urea | SHERWOOD MEDICAL COMPANY (US) | 1984-10-02 | — | — | US | claimed |
| US-4115067-A | AIR POLLUTION | COMBUSTION EQUIPMENT ASSOCIATES INC. (US) | 1978-09-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12491169-B1 | 1-naphthalenyl aminoethyl Schiff base and use as a death ligand-1 inhibitor | CD274, PDCD1, PDCD1LG2 | GAA 2746/4885HTR6 882/4885BCHE 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.