Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 2/20 | 0.41 |
| ▸ | MAOB known ✓ | P27338 | 2/20 | 0.41 |
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.40 |
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.39 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.34 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.34 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.34 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.34 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.34 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.34 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.34 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.34 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.34 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.34 |
| ▸ | HRH2 known ✓ | P25021 | 1/20 | 0.34 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564351 | 0.98 | HDAC3 (0.41) | MAOAMAOBHDAC3PARP1MEN1 | |
| SCHEMBL30385312 | 0.98 | HDAC3 (0.41) | MAOAMAOBHDAC3PARP1MEN1 | |
| Iodide SCHEMBL4322466 | 0.96 | HDAC3 (0.40) | MAOAMAOBHDAC3PARP1MEN1 | |
| Iodide SCHEMBL11870312 | 0.96 | HDAC3 (0.40) | MAOAMAOBHDAC3PARP1MEN1 | |
| SCHEMBL3069885 | 0.80 | HDAC3 (0.43) | MAOAMAOBHDAC3PARP1MEN1 | |
| SCHEMBL9316890 | 0.78 | DRD2 (0.45) | MAOAMAOBMEN1PMP22KMT2A | |
| SCHEMBL2264889 | 0.76 | MAOB (0.41) | MAOAMAOBMAPTHSD17B3DRD3 | |
| Hydrochloric Acid SCHEMBL23501064 | 0.75 | PARP1 (0.39) | MAOAMAOBHDAC3PARP1MEN1 | |
| Hydrochloric Acid SCHEMBL4419624 | 0.75 | PARP1 (0.39) | MAOAMAOBHDAC3PARP1MEN1 | |
| Hydrochloric Acid SCHEMBL28125378 | 0.75 | PARP1 (0.39) | MAOAMAOBHDAC3PARP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190040209-A1 | METHODS FOR DISSOLVING POLYMERS USING MIXTURES OF DIFFERENT IONIC LIQUIDS AND COMPOSITIONS COMPRISING THE MIXTURES | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA | 2019-02-07 | — | — | US | disclosed |
| EP-2257669-B1 | IONIC LIQUID SYSTEMS FOR THE PROCESSING OF BIOMASS, THEIR COMPONENTS AND/OR DERIVATIVES, AND MIXTURES THEREOF | UNIV ALABAMA (US) | 2017-03-22 | — | — | EP | disclosed |
| US-9394375-B2 | Compositions containing recyclable ionic liquids for use in biomass processing | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2016-07-19 | — | — | US | disclosed |
| US-20150239742-A1 | EXFOLIATION OF GRAPHITE USING IONIC LIQUIDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA | 2015-08-27 | — | — | US | disclosed |
| CN-101124251-B | Polymer dissolution in ionic liquid and blend are formed | THE UNIVERSITY OF ALABAMA (US) | 2015-08-19 | — | — | CN | disclosed |
| US-20150004733-A1 | EXFOLIATION OF THERMOELECTRIC MATERIALS AND TRANSITION METAL DICHALCOGENIDES USING IONIC LIQUIDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA | 2015-01-01 | — | — | US | disclosed |
| US-8883193-B2 | Cellulosic biocomposites as molecular scaffolds for nano-architectures | THE UNIVERSITY OF ALABAMA (US) | 2014-11-11 | — | — | US | disclosed |
| US-8784691-B2 | Conductive composites prepared using ionic liquids | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2014-07-22 | — | — | US | disclosed |
| US-8668807-B2 | Ionic liquid systems for the processing of biomass, their components and/or derivatives, and mixtures thereof | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2014-03-11 | — | — | US | disclosed |
| EP-2325246-B1 | Dissolution and processing of cellulose using ionic liquids | UNIV ALABAMA (US) | 2013-11-27 | — | — | EP | disclosed |
| US-20050288484-A1 | Polymer dissolution and blend formation in ionic liquids | UNIVERSITY OF ALABAMA (US) | 2005-12-29 | — | — | US | disclosed |
| WO-2005098546-A2 | POLYMER DISSOLUTION AND BLEND FORMATION IN IONIC LIQUIDS | THE UNIVERSITY OF ALABAMA (US) | 2005-10-20 | — | — | WO | disclosed |
| US-6824599-B2 | ADMIXING CELLULOSE WITH A MOLTEN IONIC LIQUID IN THE SUBSTANTIAL ABSENCE OF WATER OR A NITROGEN-CONTAINING BASE TO FORM AN ADMIXTURE, AND AGITATING ADMIXTURE UNTIL DISSOLUTION IS COMPLETE; UTILIZATION OF THIS RENEWABLE RAW MATERIAL | THE UNIVERSITY OF ALABAMA | 2004-11-30 | — | — | US | disclosed |
| US-6808557-B2 | Cellulose matrix encapsulation and method | THE UNIVERSITY OF ALABAMA | 2004-10-26 | — | — | US | disclosed |
| EP-1458805-A4 | DISSOLUTION AND PROCESSING OF CELLULOSE USING IONIC LIQUIDS | UNIV ALABAMA (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2004084627-A2 | CELLULOSE MATRIX ENCAPSULATION AND METHOD | THE UNIVERSITY OF ALABAMA (US) | 2004-10-07 | — | — | WO | disclosed |
| EP-1458805-A2 | DISSOLUTION AND PROCESSING OF CELLULOSE USING IONIC LIQUIDS | The University of Alabama (US) | 2004-09-22 | — | — | EP | disclosed |
| US-20040038031-A1 | Cellulose matrix encapsulation and method | ALABAMA, UNIVERSITY OF, THE | 2004-02-26 | — | — | US | disclosed |
| US-20030157351-A1 | Dissolution and processing of cellulose using ionic liquids | UNIVERSTIY OF ALABAMA, THE | 2003-08-21 | — | — | US | disclosed |
| WO-2003029329-A2 | DISSOLUTION AND PROCESSING OF CELLULOSE USING IONIC LIQUIDS | THE UNIVERSITY OF ALABAMA (US) | 2003-04-10 | — | — | WO | disclosed |