Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.80 |
| ▸ | MAOB known ✓ | P27338 | 4/20 | 0.56 |
| ▸ | MAOA known ✓ | P21397 | 3/20 | 0.56 |
| ▸ | HTR6 known ✓ | P50406 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.80 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.80 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenethylamine SCHEMBL245154 | 0.92 | HTR2A (0.94) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL16294846 | 0.90 | HTR2A (0.89) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL29277512 | 0.90 | HTR2A (0.89) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL11664723 | 0.90 | HTR2A (0.89) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL1332244 | 0.89 | — | — | |
| Phenethylamine SCHEMBL1331271 | 0.89 | — | — | |
| Phenethylamine SCHEMBL968 | 0.89 | — | — | |
| Phenethylamine SCHEMBL1799333 | 0.89 | HTR2A (1.00) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 | |
| Phenethylamine SCHEMBL1330939 | 0.89 | — | — | |
| Phenethylamine SCHEMBL27634208 | 0.89 | HTR2A (1.00) | HTR2ATAAR1CYP2A6SMN1; SMN2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163451-A1 | Methods and Compositions for Treating Conditions of the Eye | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2014-06-12 | — | — | US | disclosed |
| US-20120323162-A1 | Methods and Compositions for Treating Conditions of the Eye | MILLER JOAN W (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110144035-A1 | Methods and Compositions for Treating Conditions of the Eye | MASSACHUSETTS EYE AND EAR INFIRMARY | 2011-06-16 | — | — | US | disclosed |
| US-20090286743-A1 | Methods and Compositions for Treating Conditions of the Eye | MASSACHUSETTS EYE AND EAR INFIRMARY | 2009-11-19 | — | — | US | disclosed |
| EP-1997513-A1 | Photodynamic therapy for treating conditions of the eye | Massachussetts Eye & Ear Infirmary (US) | 2008-12-03 | — | — | EP | disclosed |
| US-7125542-B2 | Administering to the mammal an anti-angiogenesis factor and a photosensitizer to permit to localize in the chorodial neovasculature, irradiating the chorodial neovasculature with laser light | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2006-10-24 | — | — | US | disclosed |
| US-20030185834-A1 | Administering an anti-angiogenesis factor to localize in the choroidal neovasculature; administering photosensitizer; photodynamic therapy by irradiating with laser light | MASSACHUSETTS EYE AND EAR INFIRMARY | 2003-10-02 | — | — | US | disclosed |
| US-20030175282-A1 | Photodynamic therapy comprising administering angiogenesis factor antagonists and photosensitizers then irradiating with lasers, for prophylaxis of vision defects | MASSACHUSETTS EYE AND EAR INFIRMARY | 2003-09-18 | — | — | US | disclosed |
| EP-1253943-A2 | PHOTODYNAMIC THERAPY FOR TREATING CONDITIONS OF THE EYE | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2002-11-06 | — | — | EP | disclosed |
| US-20020040015-A1 | Administering to the mammal an anti-angiogenesis factor and a photosensitizer to permit to localize in the chorodial neovasculature, irradiating the chorodial neovasculature with laser light | MASSACHUSETTS EYE AND EAR INFIRMARY | 2002-04-04 | — | — | US | disclosed |
| WO-2001058240-A2 | PHOTODYNAMIC THERAPY FOR TREATING CONDITIONS OF THE EYE | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2001-08-16 | — | — | WO | disclosed |