Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 3/20 | 0.36 |
| ▸ | S1PR4 known ✓ | O95977 | 1/20 | 0.33 |
| ▸ | S1PR3 known ✓ | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 known ✓ | Q9H228 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.33 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8432627 | 1.00 | MEN1 (0.56) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| SCHEMBL157479 | 0.97 | — | — | |
| Methylamine SCHEMBL18600641 | 0.90 | MEN1 (0.53) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| SCHEMBL5052188 | 0.90 | MEN1 (0.60) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| Tromethamine SCHEMBL1933899 | 0.87 | MEN1 (0.67) | MEN1LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL6660435 | 0.86 | MEN1 (0.44) | MEN1LMNAKMT2A | |
| Phosphoric Acid SCHEMBL11822162 | 0.83 | LMNA (0.45) | MEN1LMNAKMT2AS1PR1S1PR4 | |
| SCHEMBL148930 | 0.82 | MEN1 (0.47) | MEN1LMNAKMT2A | |
| SCHEMBL9903775 | 0.79 | MEN1 (0.47) | MEN1LMNAKMT2AS1PR1TNNC1 | |
| SCHEMBL1131443 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3931399-A | MULTISTAGE FROM EXTRACTION OF HUMAN PLACENTAE | BEHRINGWERKE AKTIENGESELLSCHAFT (DT) | 1976-01-06 | — | — | US | claimed |
| CN-118434449-A | Compositions comprising therapeutic nucleic acids and targeted saponins for the treatment of muscle wasting disorders | 萨普雷米科技有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-118414172-A | Targeted saponin-nucleic acid conjugates for the treatment of muscle wasting disorders | 萨普雷米科技有限公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-109880840-B | In vivo biotinylation labeling system for recombinant protein escherichia coli | 福建农林大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-109476643-B | Pyrazolylaminobenzimidazole derivatives as JAK inhibitors | 伊莱利利公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-108026076-B | 4- (3-pyrazolyl amino) -benzimidazole compounds and their use as JAK1 inhibitors | 伊莱利利公司 | 2020-07-10 | — | — | CN | disclosed |
| CN-108072761-B | Application of MASP-1 in distinguishing initial outbreak from classical type 1diabetes | 中国科学院上海生命科学研究院 | 2020-03-17 | — | — | CN | disclosed |
| US-8148104-B2 | Xylanase, microorganisms producing it, DNA molecules, methods for preparing this xylanase and uses of the latter | DANISCO US INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8039259-B2 | Mixture comprising mannitol for suspending animal or human cells and for dissolving biologically active molecules in order to introduce molecules into cells using electric current | LONZA COLOGNE GMBH (DE) | 2011-10-18 | — | — | US | disclosed |
| US-8003389-B2 | Mixture comprising mannitol for suspending animal or human cells and for dissolving biologically active molecules in order to introduce molecules into cells using electric current | LONZA COLOGNE GMBH (DE) | 2011-08-23 | — | — | US | disclosed |
| EP-0559868-A1 | AN ASSAY FOR A NEW GAUCHER DISEASE MUTATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993006244-A1 | AN ASSAY FOR A NEW GAUCHER DISEASE MUTATION | THE SCRIPPS RESEARCH INSTITUTE (US) | 1993-04-01 | — | — | WO | disclosed |
| US-4621055-A | Process for producing biologically active factors | THEURER KARL (DE) | 1986-11-04 | — | — | US | disclosed |
| EP-0188372-A2 | Analytical element, composition, kit and method for determination of theophylline by enzyme inhibition | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1986-07-23 | — | — | EP | disclosed |
| US-4438198-A | IMMOBILIZED ENZYMES ON FIBRIN IN AGAROSE SUSPENSION | TRIMEDYNE, INC. (US) | 1984-03-20 | — | — | US | disclosed |
| US-4332890-A | HEMAGGLUTINATION WITH PARTICLES SENSITIZED WITH ANTIBODIES | ABBOTT LABORATORIES (US) | 1982-06-01 | — | — | US | disclosed |
| US-4267271-A | Radioimmunoassay for isoenzymes of creative kinase having a B-subunit and reagents therefor | WASHINGTON UNIVERSITY (US) | 1981-05-12 | — | — | US | disclosed |
| US-4237219-A | Radioimmunoassay assay and reagents for MB isoenzyme of CK | WASHINGTON UNIVERSITY (US) | 1980-12-02 | — | — | US | disclosed |
| US-4129648-A | BLOOD PLASMA OR SERUM EXTRACT | COLLIER HARRY O J | 1978-12-12 | — | — | US | disclosed |
| US-4071037-A | Preparation and method of use of enzyme effective for conversion and detection of carbon monoxide | SCHEINBERG ISRAEL HERBERT | 1978-01-31 | — | — | US | disclosed |