Eperisone

Eperisone

SCHEMBL218337

CCc1ccc(C(=O)C(C)CN2CCCCC2)cc1.Cl

nearest known ligand 0.97

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Eperisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 known ✓ Q9Y5N1 4/20 0.97
CHRM2 known ✓ P08172 2/20 0.97
ADRA2B known ✓ P18089 2/20 0.97
DRD3 known ✓ P35462 2/20 0.97
SIGMAR1 known ✓ Q99720 2/20 0.97
ADRA2C known ✓ P18825 1/20 0.97
CHRM3 known ✓ P20309 1/20 0.97
OPRD1 known ✓ P41143 1/20 0.97
KCNH2 known ✓ Q12809 1/20 0.97
SLC6A4 known ✓ P31645 1/20 0.49
CYP2D6 P10635 2/20 0.97
ALDH1A1 P00352 5/20 0.74
LMNA P02545 4/20 0.74
L3MBTL1 Q9Y468 1/20 0.51
USP2 O75604 1/20 0.50
ALOX15 P16050 1/20 0.50
NTSR1 P30989 1/20 0.49
MITF O75030 3/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
RAB9A P51151 3/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eperisone SCHEMBL1331682 0.99 HRH3 (1.00) HRH3CHRM2ADRA2BDRD3SIGMAR1
Inaperisone SCHEMBL3990438 0.99 CHRM2 (0.94) HRH3CHRM2ADRA2BDRD3SIGMAR1
Eperisone SCHEMBL194769 0.99 HRH3 (1.00) HRH3CHRM2ADRA2BDRD3SIGMAR1
Inaperisone SCHEMBL250427 0.97 HRH3 (0.97) HRH3CHRM2ADRA2BDRD3SIGMAR1
Inaperisone SCHEMBL1650087 0.94 HRH3 (0.92) HRH3CHRM2ADRA2BDRD3SIGMAR1
Hydrochloric Acid SCHEMBL9850399 0.93 CHRM2 (0.83) HRH3CHRM2ADRA2BDRD3SIGMAR1
Eperisone SCHEMBL2491287 0.92 HRH3 (0.87) HRH3CHRM2ADRA2BDRD3SIGMAR1
Eperisone SCHEMBL1329969 0.92 HRH3 (0.87) HRH3CHRM2ADRA2BDRD3SIGMAR1
Eperisone SCHEMBL1331476 0.91 HRH3 (0.85) HRH3CHRM2ADRA2BDRD3SIGMAR1
Eperisone SCHEMBL2489151 0.91 HRH3 (0.85) HRH3CHRM2ADRA2BDRD3SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 634 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119792221-A Pharmaceutical composition and preparation method and application thereof 江苏吴中医药集团有限公司 2025-04-11 CN claimed
CN-119330913-A Preparation method of eperisone hydrochloride 康普药业股份有限公司 2025-01-21 CN claimed
CN-119280238-A Medicine composition containing eperisone hydrochloride and capable of effectively controlling content of impurity D and preparation method thereof 湖南九维生物医药有限公司 2025-01-10 CN claimed
CN-119040428-A Composition for detecting eperisone hydrochloride microorganisms, experimental method and application 康普药业股份有限公司 2024-11-29 CN claimed
CN-118436593-A External preparation of eperisone and application thereof 山东序列生物科技有限公司 2024-08-06 CN claimed
CN-117209455-B Refining and purifying method of eperisone hydrochloride 北京沃邦医药科技有限公司 2024-05-28 CN claimed
CN-118032957-A Method for detecting eperisone hydrochloride related substances 康普药业股份有限公司 2024-05-14 CN claimed
CN-117838644-A Eperisone hydrochloride tablet and preparation method thereof 湖南尚众合生物医药有限公司 2024-04-09 CN claimed
CN-117720481-A Preparation method of eperisone hydrochloride and application of eperisone hydrochloride in preparation 重庆圣华曦药业股份有限公司 2024-03-19 CN claimed
CN-117534634-A Preparation method of eperisone hydrochloride 湖南九维生物医药有限公司 2024-02-09 CN claimed
EP-0580860-B2 METHOD OF MANUFACTURING SOLID DISPERSION NIPPON SHINYAKU CO LTD (JP) 2004-12-15 EP claimed
US-6750291-B2 POLYURETHANE AND 1*50% BY WEIGHT ADDITION POLYMERIZATION POLYMER HAVING FUNCTIONAL GROUP OF CARBOXYLIC ACID DERIVATIVE; TRANSDERMAL DRUG DELIVERY PACIFIC CORPORATION (KR) 2004-06-15 US claimed
US-6733785-B1 WATER SOLUBLE POLYVINYL ALCOHOL PERMEATION CONTROLLING FILM FOR STORAGE STABILITY; ADHESIVE PATCH; NICORANDIL, DOPAMINE HYDROCHLORIDE OR EPERISONE HYDROCHLORIDE LINTEC CORPORATION (JP) 2004-05-11 US claimed
US-20030199644-A1 Film-forming agent for drug delivery and preparation for percutaneous administration containing the same PACIFIC CORPORATION (KR) 2003-10-23 US claimed
US-5811547-A Method for inducing crystalline state transition in medicinal substance NIPPON SHINYAJU CO., LTD. (JP) 1998-09-22 US claimed
US-5700410-A Method of manufacturing wax matrices NIPPON SHINYAKU CO., LTD. (JP) 1997-12-23 US claimed
EP-0580860-B1 METHOD OF MANUFACTURING SOLID DISPERSION NIPPON SHINYAKU CO LTD (JP) 1997-10-22 EP claimed
US-5252588-A Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1993-10-12 US claimed
US-5073375-A Monoglyceride or lactic acid ester SANSHO CO., LTD. (JP) 1991-12-17 US claimed
US-5059427-A PHARMACEUTICAL PREPARATION FOR PERCUTANEOUS ADMINISTRATION CONTAINING EPERISONE OR TOLPERISONE OR SALT THEREOF SANSHO CO., LTD. (JP) 1991-10-22 US claimed