Trimethylammonium

Trimethylammonium

SCHEMBL2376096

CCCC=CC(N)=O.CN(C)C.Cl

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
PPARG known ✓ P37231 3/20 0.31
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
FAAH O00519 3/20 0.35
SOAT1 P35610 2/20 0.35
MEN1 O00255 1/20 0.35
TP53 P04637 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C19 P33261 1/20 0.35
KMT2A Q03164 1/20 0.35
CNR1 P21554 1/20 0.33
PTPN1 P18031 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
KDM4E B2RXH2 2/20 0.32
PPARA Q07869 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trimethylammonium SCHEMBL2776569 0.98 TAS1R3 (0.41) TAS1R3TAS1R1FAAHSOAT1MEN1
SCHEMBL3504009 0.91
SCHEMBL1873475 0.91
SCHEMBL1873474 0.91
SCHEMBL943834 0.91 TAS1R3 (0.45) TAS1R3TAS1R1FAAHSOAT1MEN1
SCHEMBL944831 0.91 TAS1R3 (0.45) TAS1R3TAS1R1FAAHSOAT1MEN1
Butane SCHEMBL8373879 0.89 TAS1R3 (0.44) TAS1R3TAS1R1FAAHSOAT1MEN1
Hydrochloric Acid SCHEMBL17289000 0.88 TAS1R3 (0.38) TAS1R3TAS1R1FAAHSOAT1MEN1
Dimethylamine SCHEMBL3824284 0.84 TAS1R3 (0.46) TAS1R3TAS1R1FAAHSOAT1MEN1
Trimethylammonium SCHEMBL17289187 0.84 TAS1R3 (0.33) TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3387025-B1 INVERSE EMULSION COMPOSITIONS KEMIRA OYJ (FI) 2023-04-26 EP claimed
US-20190241794-A1 LIQUID POLYMER COMPOSITIONS STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) 2019-08-08 US claimed
US-20190241793-A1 INVERSE EMULSION COMPOSITIONS STERLING SPECIALTY CHEMICALS HOLDING UK LIMITED (GB) 2019-08-08 US claimed
US-20190203104-A1 Liquid Polymer Compositions KEMIRA OYJ (FI) 2019-07-04 US claimed
US-20180362833-A1 Inverse Emulsion Compositions KEMIRA OYJ (FI) 2018-12-20 US claimed
EP-1987083-B1 POLYMERIZABLE SILICONE COPOLYOL MACROMERS AND POLYMERS MADE THEREFROM LUBRIZOL ADVANCED MAT INC (US) 2014-08-27 EP claimed
US-8796484-B2 Polymerizable silicone copolyol macromers and polymers made therefrom LUBRIZOL ADVANCED MATERIALS, INC. (US) 2014-08-05 US claimed
US-20130137844-A1 Polymerizable Silicone Copolyol Macromers And Polymers Made Therefrom LUBRIZOL ADVANCED MATERIALS, INC. (US) 2013-05-30 US claimed
EP-1988873-B1 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME LUBRIZOL ADVANCED MAT INC (US) 2013-01-09 EP claimed
US-8021650-B2 Polymers containing silicone copolyol macromers and personal care compositions containing same LUBRIZOL ADVANCED MATERIALS, INC. (US) 2011-09-20 US claimed
JP-2009528402-A 2009-08-06 JP claimed
EP-1988873-A2 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME Lubrizol Advanced Materials, Inc. (US) 2008-11-12 EP claimed
EP-1987083-A2 POLYMERIZABLE SILICONE COPOLYOL MACROMERS AND POLYMERS MADE THEREFROM Lubrizol Advanced Materials, Inc. (US) 2008-11-05 EP claimed
WO-2007101059-A2 POLYMERS CONTAINING SILICONE COPOLYOL MACROMERS AND PERSONAL CARE COMPOSITIONS CONTAINING SAME LUBRIZOL ADVANCED MATERIALS, INC. (US) 2007-09-07 WO claimed
WO-2007101048-A2 POLYMERIZABLE SILICONE COPOLYOL MACROMERS AND POLYMERS MADE THEREFROM LUBRIZOL ADVANCED MATERIALS, INC. (US) 2007-09-07 WO claimed
US-20070202069-A1 Polymers Containing Silicone Copolyol Macromers and Personal Care Compositions Containing Same LUBRIZOL ADVANCED MATERIALS, INC. 2007-08-30 US claimed
US-20070203311-A1 Polymerizable Silicone Copolymer Macromers and Polymers Made Therefrom LUBRIZOL ADVANCED MATERIALS, INC. 2007-08-30 US claimed
US-20240182779-A1 METHODS FOR HYDROCARBON RECOVERY CHEVRON U.S.A. INC. 2024-06-06 US disclosed
US-20060039939-A1 Associative thickeners for aqueous systems LUBRIZOL ADVANCED MATERIALS, INC. 2006-02-23 US disclosed
US-6486245-B1 Self-arranging coating NANOGATE TECHNOLOGIES GMBH (DE) 2002-11-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060039939-A1 Associative thickeners for aqueous systems ELL, TAF1, TARBP1 PPARG 774/4885TAS1R3 105/4885TAS1R1 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.