Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27450396 | 1.00 | — | — | |
| SCHEMBL48555 | 0.95 | — | — | |
| SCHEMBL3343202 | 0.91 | MAN1B1 (0.57) | — | |
| Bromide SCHEMBL27700910 | 0.91 | — | — | |
| Methane SCHEMBL28046548 | 0.91 | — | — | |
| Hydrochloric Acid SCHEMBL17711450 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL17761022 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL17761051 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL221781 | 0.87 | — | — | |
| Ethane SCHEMBL9684365 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3654 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425720-A | Preparation method of delafloxacin meglumine | 广东东阳光药业有限公司 | 2023-07-14 | — | — | CN | claimed |
| CN-107778293-B | Improved preparation method of delafloxacin | 鲁南制药集团股份有限公司 | 2023-06-16 | — | — | CN | claimed |
| CN-111825592-B | Synthetic method of 3-hydroxyazetidine hydrochloride | 四川同晟生物医药有限公司 | 2022-07-29 | — | — | CN | claimed |
| CN-111825592-A | Synthetic method of 3-hydroxyazetidine hydrochloride | 四川同晟生物医药有限公司 | 2020-10-27 | — | — | CN | claimed |
| CN-110028432-A | A kind of (3- amino-azetidine -1- base)-cyclopropyl-ketone preparation method | 南京合巨药业有限公司 | 2019-07-19 | — | — | CN | claimed |
| CN-108484468-A | The preparation method of aryl azetidin compounds | 南京大学 | 2018-09-04 | — | — | CN | claimed |
| CN-108084161-A | The preparation method of De Lasha stars and its intermediate | 北京沃邦医药科技有限公司 | 2018-05-29 | — | — | CN | claimed |
| US-20180134713-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF {1-(ETHYLSULFONYL)-3-[4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]AZETIDIN-3-YL}ACETONITRILE | LILLY CO ELI (US) | 2018-05-17 | — | — | US | claimed |
| EP-3310781-A1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF {1-(ETHYLSULFONYL)-3-[4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL]AZETIDIN-3-YL}ACETONITRILE | Eli Lilly and Company (US) | 2018-04-25 | — | — | EP | claimed |
| CN-107660206-A | For preparing the method and intermediate of { base of 1 (ethylsulfonyl) 3 [base of 4 (base of 7H pyrrolo-es [2,3 d] pyrimidine 4) 1H pyrazoles 1] azetidine 3 } acetonitrile | 伊莱利利公司 | 2018-02-02 | — | — | CN | claimed |
| EP-2305666-B1 | Preparation of pyridonecarboxylic acid antibacterials | ABBVIE INC (US) | 2014-06-25 | — | — | EP | claimed |
| US-20140155610-A1 | PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS | ABBVIE, INC. (US) | 2014-06-05 | — | — | US | claimed |
| CN-102976993-A | Synthetic method of 3-hydroxyazetidine hydrochloride | HANGZHOU ALLSINO CHEMICAL CO LTD | 2013-03-20 | — | — | CN | claimed |
| CN-102827052-A | Method for synthesizing 3-hydroxy-azetidinehydrochloride | GANSU KOREY PHARM CO LTD | 2012-12-19 | — | — | CN | claimed |
| CN-102250080-A | Preparation method of 1-(4, 5-dihydro-2-thiazolinyl)-3-mercaptoazetidine hydrochloride | GUANGZHOU BAIYUNSHAN PHARMACEUTICAL GENERAL PLANT GUANGZHOU BAIYUNSHAN PHARMACEUTICAL CO LTD | 2011-11-23 | — | — | CN | claimed |
| CN-102212026-A | Preparation method for 1-tertbutyloxycarbonyl-3-iodoazetidine | SHANGHAI ELITTES ORGANICS CO LTD | 2011-10-12 | — | — | CN | claimed |
| EP-2305666-A1 | Preparation of pyridonecarboxylic acid antibacterials | Abbott Laboratories (US) | 2011-04-06 | — | — | EP | claimed |
| EP-1789392-A2 | PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2007-05-30 | — | — | EP | claimed |
| US-20060128686-A1 | reacting ethyl 1-(6-amino-3,5-difluoropyridin-2-yl)-6-fluoro-7-(3-(isobutyryloxy)azetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate and N-chlorosuccinimide, forming 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxlic acid | MELINTA SUBSIDIARY CORP. (F/K/A MELINTA THERAPEUTICS, INC.) | 2006-06-15 | — | — | US | claimed |
| WO-2006015194-A2 | PREPARATION OF PYRIDONECARBOXYLIC ACID ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2006-02-09 | — | — | WO | claimed |