Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL933615 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL932735 | 1.00 | — | — | |
| SCHEMBL18973928 | 0.97 | — | — | |
| SCHEMBL1603964 | 0.97 | — | — | |
| SCHEMBL5217527 | 0.97 | — | — | |
| Alcohol SCHEMBL28644071 | 0.89 | CA1 (0.38) | — | |
| Trimethylammonium SCHEMBL27707662 | 0.89 | CA1 (0.38) | — | |
| SCHEMBL1400213 | 0.87 | TSHR (0.48) | — | |
| Trimethylammonium SCHEMBL27455354 | 0.85 | CA1 (0.39) | — | |
| Phosphoric Acid SCHEMBL28639835 | 0.83 | GABRR1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 167 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119192072-A | High-temperature acidification corrosion inhibitor for oil field and preparation method and application thereof | 佛山市天辰洁能环保技术有限公司 | 2024-12-27 | — | — | CN | claimed |
| CN-115219632-B | HPLC-ELSD detection method for (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2024-04-05 | — | — | CN | claimed |
| CN-112110910-B | Method for preparing rivaroxaban intermediate and method for preparing rivaroxaban from rivaroxaban intermediate | 上海特化医药科技有限公司 | 2024-03-19 | — | — | CN | claimed |
| CN-116789557-A | Synthesis method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 迪嘉药业集团股份有限公司 | 2023-09-22 | — | — | CN | claimed |
| CN-115219632-A | HPLC-ELSD detection method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2022-10-21 | — | — | CN | claimed |
| CN-114200031-A | Method for detecting impurity (S) -1-amino-3-chloro-2-propanol hydrochloride in rivaroxaban intermediate III | 南京生命能科技开发有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-111077248-A | Method for detecting (S) -1-amino-3-chloro-2-propanol hydrochloride by UPLC-MS/MS | 江苏乾元生物科技有限公司 | 2020-04-28 | — | — | CN | claimed |
| CN-103467310-B | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2015-05-27 | — | — | CN | claimed |
| EP-1028940-B1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN CO LLC (US) | 2007-04-18 | — | — | EP | claimed |
| US-20040006238-A1 | Process to produce oxazolidinones | PHARMACIA & UPJOHN COMPANY | 2004-01-08 | — | — | US | claimed |
| US-20030216572-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY | 2003-11-20 | — | — | US | claimed |
| US-6613944-B2 | Reacting phthalimide with an epoxide in the presence of potassium phthalimide in DMF or DMAC to give a phthalimide alkylalcohol, deacylation with aqueous acid | PHARMACIA & UPJOHN COMPANY | 2003-09-02 | — | — | US | claimed |
| US-20030130509-A1 | PROCESS TO PRODUCE 3-CARBON AMINO ALCOHOL SALTS | PHARMACIA & UPJOHN COMPANY | 2003-07-10 | — | — | US | claimed |
| US-6563003-B2 | The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2-CH2-C*H(OH)-CH2-NH-CO-RN (VIIIA) and processes for production of pharmacologically useful oxazolidinones. | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | claimed |
| US-20030065219-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY | 2003-04-03 | — | — | US | claimed |
| US-20020095054-A1 | Process to produce oxazolidinones | PHARMACIA & UPJOHN COMPANY | 2002-07-18 | — | — | US | claimed |
| US-20020032348-A1 | Process to produce oxazolidinones | PEARLMAN BRUCE ALLEN (US) | 2002-03-14 | — | — | US | claimed |
| EP-1028940-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-23 | — | — | EP | claimed |
| WO-1999024393-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 1999-05-20 | — | — | WO | claimed |
| CN-121673250-B | Polyamino cationic lipids containing carbamate structures, compositions comprising same and uses | 北京悦康科创医药科技股份有限公司 | 2026-05-15 | — | — | CN | disclosed |
| US-20260062394-A1 | PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2026-03-05 | — | — | US | disclosed |
| CN-119192072-B | High-temperature acidification corrosion inhibitor for oil field and preparation method and application thereof | 佛山市天辰洁能环保技术有限公司 | 2025-07-22 | — | — | CN | disclosed |
| EP-4568961-A1 | PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2025-06-18 | — | — | EP | disclosed |
| US-20250066340-A1 | METHOD FOR SYNTHESIZING RIVAROXABAN | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2025-02-27 | — | — | US | disclosed |
| CN-119192072-A | High-temperature acidification corrosion inhibitor for oil field and preparation method and application thereof | 佛山市天辰洁能环保技术有限公司 | 2024-12-27 | — | — | CN | disclosed |
| CN-119192072-A | High-temperature acidification corrosion inhibitor for oil field and preparation method and application thereof | 佛山市天辰洁能环保技术有限公司 | 2024-12-27 | — | — | CN | disclosed |
| WO-2024200838-A1 | NEW ODILORHABDINS ANALOGUES AS ANTIBIOTICS AGAINST MULTI-RESISTANT BACTERIA | NOSOPHARM (FR) | 2024-10-03 | — | — | WO | disclosed |
| EP-4434983-A1 | METHOD FOR SYNTHESIZING RIVAROXABAN | Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) | 2024-09-25 | — | — | EP | disclosed |
| CN-118176191-A | Synthesis method of rivaroxaban | 浙江华海药业股份有限公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-115219632-B | HPLC-ELSD detection method for (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-115219632-B | HPLC-ELSD detection method for (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-115219632-B | HPLC-ELSD detection method for (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2024-04-05 | — | — | CN | disclosed |
| CN-112110910-B | Method for preparing rivaroxaban intermediate and method for preparing rivaroxaban from rivaroxaban intermediate | 上海特化医药科技有限公司 | 2024-03-19 | — | — | CN | disclosed |
| WO-2024035618-A1 | PROCESSES FOR PREPARING OXAZOLIDINONE COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2024-02-15 | — | — | WO | disclosed |
| CN-117554526-A | Method for determining S-1-amino-3-chloro-2-propanol hydrochloride and enantiomer thereof | 重庆天地药业有限责任公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-116789557-A | Synthesis method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 迪嘉药业集团股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116789557-A | Synthesis method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 迪嘉药业集团股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116789557-A | Synthesis method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 迪嘉药业集团股份有限公司 | 2023-09-22 | — | — | CN | disclosed |
| CN-116675685-A | Pyridine-containing bisoxazolidone compound and synthetic method and application thereof | 东北农业大学 | 2023-09-01 | — | — | CN | disclosed |
| WO-2023088229-A1 | METHOD FOR SYNTHESIZING RIVAROXABAN | 浙江华海药业股份有限公司 | 2023-05-25 | — | — | WO | disclosed |
| CN-115261385-A | Method for sequence modification of small nucleic acid and application thereof | 纳肽得有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-115219632-A | HPLC-ELSD detection method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115219632-A | HPLC-ELSD detection method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-115219632-A | HPLC-ELSD detection method of (S) -1-amino-3-chloro-2-propanol hydrochloride | 山东达因海洋生物制药股份有限公司 | 2022-10-21 | — | — | CN | disclosed |
| CN-114200031-A | Method for detecting impurity (S) -1-amino-3-chloro-2-propanol hydrochloride in rivaroxaban intermediate III | 南京生命能科技开发有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114200031-A | Method for detecting impurity (S) -1-amino-3-chloro-2-propanol hydrochloride in rivaroxaban intermediate III | 南京生命能科技开发有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-114200031-A | Method for detecting impurity (S) -1-amino-3-chloro-2-propanol hydrochloride in rivaroxaban intermediate III | 南京生命能科技开发有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-110003209-B | Macrocyclic compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2022-01-25 | — | — | CN | disclosed |
| CN-110003214-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2021-12-21 | — | — | CN | disclosed |
| CN-108135887-B | Oxazolidinone compounds and methods of use as antibacterial agents | 默沙东公司 | 2021-07-30 | — | — | CN | disclosed |
| US-10947205-B2 | Oxazolidinone compounds and methods of use thereof as antibacterial agents | MERCK SHARP & DOHME CORP. (US) | 2021-03-16 | — | — | US | disclosed |
| US-20210061777-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-03-04 | — | — | US | disclosed |
| US-20200291026-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2020-09-17 | — | — | US | disclosed |
| CN-106146332-B | Method for separating and determining linezolid raw material X3 and process impurity X2 thereof | 重庆华邦胜凯制药有限公司 | 2020-09-11 | — | — | CN | disclosed |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-09-01 | — | — | US | disclosed |
| EP-3140275-B1 | COMBINATION OF A BH4 ANTAGONIST AND A MTOR INHIBITOR FOR LUNG CANCER THERAPY | UNIV EMORY (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10647730-B2 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-05-12 | — | — | US | disclosed |
| CN-111077248-A | Method for detecting (S) -1-amino-3-chloro-2-propanol hydrochloride by UPLC-MS/MS | 江苏乾元生物科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-111077248-A | Method for detecting (S) -1-amino-3-chloro-2-propanol hydrochloride by UPLC-MS/MS | 江苏乾元生物科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-111077248-A | Method for detecting (S) -1-amino-3-chloro-2-propanol hydrochloride by UPLC-MS/MS | 江苏乾元生物科技有限公司 | 2020-04-28 | — | — | CN | disclosed |
| CN-106458821-B | BH4 antagonists and methods relating thereto | 爱默蕾大学 | 2019-12-31 | — | — | CN | disclosed |
| US-20190248753-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME LLC | 2019-08-15 | — | — | US | disclosed |
| EP-3521291-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2019-08-07 | — | — | EP | disclosed |
| US-10251889-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | Array BioPharm Inc. (US) | 2019-04-09 | — | — | US | disclosed |
| US-20190031684-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2019-01-31 | — | — | US | disclosed |
| EP-3205654-B1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2019-01-02 | — | — | EP | disclosed |
| US-20180290987-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. | 2018-10-11 | — | — | US | disclosed |
| US-20180263984-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-09-20 | — | — | US | disclosed |
| EP-3364968-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | Merck Sharp & Dohme Corp. (US) | 2018-08-29 | — | — | EP | disclosed |
| US-9980936-B2 | BH4 antagonists and methods related thereto | EMORY UNIVERSITY (US) | 2018-05-29 | — | — | US | disclosed |
| EP-3299372-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OFSUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2018-03-28 | — | — | EP | disclosed |
| US-9902741-B2 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2018-02-27 | — | — | US | disclosed |
| US-9840519-B2 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| EP-2451812-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2017-11-08 | — | — | EP | disclosed |
| US-9796724-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-10-24 | — | — | US | disclosed |
| US-9782415-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20170283435-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-10-05 | — | — | US | disclosed |
| US-9750744-B2 | Macrocyclic compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| EP-3205654-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9718822-B2 | Macrocyclic compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9682979-B2 | Substituted pyrazolo [1,5-A] pyrimidine compounds as TRK kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170119770-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-05-04 | — | — | US | disclosed |
| EP-2918588-B1 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2017066964-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017070024-A1 | OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20170114069-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-27 | — | — | US | disclosed |
| US-20170112842-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-27 | — | — | US | disclosed |
| US-20170114059-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-27 | — | — | US | disclosed |
| US-20170107232-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-20 | — | — | US | disclosed |
| US-20170071896-A1 | BH4 Antagonists and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-03-16 | — | — | US | disclosed |
| CN-103864773-B | Razaxaban and its preparation method of intermediate | 北京藏卫信康医药研发有限公司 | 2017-03-15 | — | — | CN | disclosed |
| CN-106146332-A | Separate and measure Linezolid raw material X3 and the method for process contaminants X2 thereof | 重庆华邦胜凯制药有限公司 | 2016-11-23 | — | — | CN | disclosed |
| US-9493476-B2 | Macrocyclic compounds as trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| CN-105693720-A | Macrocyclic compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-22 | — | — | CN | disclosed |
| EP-2738169-B1 | OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PREPARATION OF ANTIBIOTICS | SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO LTD (CN) | 2016-03-23 | — | — | EP | disclosed |
| CN-102971322-B | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-02-17 | — | — | CN | disclosed |
| US-20150336970-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2015-11-26 | — | — | US | disclosed |
| US-20150299160-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2015-10-22 | — | — | US | disclosed |
| EP-2918588-A1 | Macrocyclic compounds as TRK kinase inhibitors | Array Biopharma, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| CN-103467310-B | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-103467310-B | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2015-05-27 | — | — | CN | disclosed |
| CN-103467310-B | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2015-05-27 | — | — | CN | disclosed |
| US-20150133657-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN | RANBAXY LABORATORIES LIMITED (IN) | 2015-05-14 | — | — | US | disclosed |
| EP-2855465-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN | Ranbaxy Laboratories Limited (IN) | 2015-04-08 | — | — | EP | disclosed |
| CN-102827155-B | Oxazolidinone compounds and application of oxazolidinone compound in preparation of antibiotic medicine | UNIV SICHUAN | 2015-03-25 | — | — | CN | disclosed |
| EP-2838897-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF | Ranbaxy Laboratories Limited (IN) | 2015-02-25 | — | — | EP | disclosed |
| US-8946436-B2 | Oxazolidinone compounds and their uses in preparation of antibiotics | SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD. (CN) | 2015-02-03 | — | — | US | disclosed |
| US-20150031667-A1 | Substituted Pyrazolo [1,5-A] Pyrimidine Compounds as TRK Kinase Inhibitors | ARRAY BIOPHARMA, INC. | 2015-01-29 | — | — | US | disclosed |
| WO-2015011617-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN | RANBAXY LABORATORIES LIMITED (IN) | 2015-01-29 | — | — | WO | disclosed |
| US-8933084-B2 | Macrocyclic compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-01-13 | — | — | US | disclosed |
| EP-2571883-B1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-01-07 | — | — | EP | disclosed |
| CN-101619061-B | Cyanopyridyl-replaced oxazolidinone compound | UNIV SHENYANG PHARMACEUTICAL | 2014-12-17 | — | — | CN | disclosed |
| CN-104140399-A | Preparation method of linezolid | JIANGSU HANSOH PHARMACEUTICAL | 2014-11-12 | — | — | CN | disclosed |
| US-8791123-B2 | Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA, INC. (US) | 2014-07-29 | — | — | US | disclosed |
| EP-2738169-A1 | OXAZOLIDINONE COMPOUNDS AND THEIR USES IN PREPARATION OF ANTIBIOTICS | SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD. (CN) | 2014-06-04 | — | — | EP | disclosed |
| US-20140142144-A1 | Oxazolidinone Compounds and Their Uses in Preparation of Antibiotics | SI CHUAN UNIVERSITY (CN) | 2014-05-22 | — | — | US | disclosed |
| CN-103467310-A | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2013-12-25 | — | — | CN | disclosed |
| CN-103467310-A | Separation and purification method for (S)-1-amino-3-chloro-2-propanol hydrochloride | CHONGQING HUIJIAN BIOTECH CO LTD | 2013-12-25 | — | — | CN | disclosed |
| CN-102952025-B | Preparation method of (S)-1-amino-3-chloro-2-propyl alcohol hydrochloride | TIANJIN SCIPHARMACN LTD | 2013-12-11 | — | — | CN | disclosed |
| CN-102952025-B | Preparation method of (S)-1-amino-3-chloro-2-propyl alcohol hydrochloride | TIANJIN SCIPHARMACN LTD | 2013-12-11 | — | — | CN | disclosed |
| WO-2013175431-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN | RANBAXY LABORATORIES LIMITED (IN) | 2013-11-28 | — | — | WO | disclosed |
| WO-2013156936-A1 | PROCESS FOR THE PREPARATION OF RIVAROXABAN AND INTERMEDIATES THEREOF | RANBAXY LABORATORIES LIMITED (IN) | 2013-10-24 | — | — | WO | disclosed |
| US-20130203776-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2013-08-08 | — | — | US | disclosed |
| WO-2013046211-A1 | PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF | SYMED LABS LIMITED (IN) | 2013-04-04 | — | — | WO | disclosed |
| CN-102971322-A | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC | 2013-03-13 | — | — | CN | disclosed |
| CN-102952025-A | Preparation method of (S)-1-amino-3-chloro-2-propyl alcohol hydrochloride | TIANJIN SCIPHARMACN LTD | 2013-03-06 | — | — | CN | disclosed |
| CN-102952025-A | Preparation method of (S)-1-amino-3-chloro-2-propyl alcohol hydrochloride | TIANJIN SCIPHARMACN LTD | 2013-03-06 | — | — | CN | disclosed |
| CN-102596957-A | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC | 2012-07-18 | — | — | CN | disclosed |
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-05-03 | — | — | US | disclosed |
| WO-2011146336-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| CN-101948442-A | Preparation method of linezolid and preparation thereof | JIAN FU | 2011-01-19 | — | — | CN | disclosed |
| WO-2010084514-A2 | A PROCESS FOR THE PREPARATION OF (5S)-(N)-[[3-[3-FLUORO-4-(4-MORPHOLINYL) PHENYL]-2-OXO-5-OXAZOLIDINYL] METHYL] ACETAMIDE | NEULAND LABORATORIES LTD. (IN) | 2010-07-29 | — | — | WO | disclosed |
| US-20080146573-A1 | PREPARATION AND UTILITY OF SUBSTITUTED OXZOLIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-06-19 | — | — | US | disclosed |
| WO-2008070619-A1 | DEUTERATED OXAZOLIDINONES AND THEIR USE AS ANTIBIOTICS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2007132990-A1 | PROCESS FOR THE PREPARATION OF CHIRAL GLYCIDYLPHTHALIMIDE IN HIGHLY OPTICAL PURITY | RSTECH CORPORATION (KR) | 2007-11-22 | — | — | WO | disclosed |
| EP-1380121-B1 | PROCESS TO PREPARE OXAZOLIDINONES | PHARMACIA & UPJOHN CO LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1772453-A1 | Process to produce Oxazolidinones | Pharmacia & Upjohn Company LLC (US) | 2007-04-11 | — | — | EP | disclosed |
| US-7087784-B2 | Process to prepare oxazolidinones | PHARMACIA & UPJOHN (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1328509-B1 | METHODS OF PRODUCING OXAZOLIDINONE COMPOUNDS | PHARMACIA & UPJOHN CO LLC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-6998420-B2 | Oxazolidinone compounds | PHARMACIA & UPJOHN COMPANY (US) | 2006-02-14 | — | — | US | disclosed |
| US-6887995-B2 | Process to prepare oxazolidinones | PHARMACIA & UPJOHN COMPANY (US) | 2005-05-03 | — | — | US | disclosed |
| US-20040220407-A1 | Process to prepare oxazolidinones | PERRAULT WILLIAM R | 2004-11-04 | — | — | US | disclosed |
| US-20040143131-A1 | in particular,manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol, intermediates | PHARMACIA & UPJOHN COMPANY | 2004-07-22 | — | — | US | disclosed |
| US-6740754-B2 | CYCLIZATION OF CARBAMATE WITH SECONDARY ALCOHOL, EPOXIDE OR ESTER REACTANT | PHARMACIA & UPJOHN COMPANY | 2004-05-25 | — | — | US | disclosed |
| US-6716980-B2 | CYCLIZATION AND ACYLATION OF CARBAMATE | PHARMACIA & UPJOHN COMPANY | 2004-04-06 | — | — | US | disclosed |
| EP-1380121-A2 | PROCESS TO PREPARE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20040006238-A1 | Process to produce oxazolidinones | PHARMACIA & UPJOHN COMPANY | 2004-01-08 | — | — | US | disclosed |
| US-20030216572-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY | 2003-11-20 | — | — | US | disclosed |
| EP-1071654-B1 | A PROCESS FOR PREPARING CHIRAL (S)-2,3-DISUBSTITUTED-1-PROPYLAMINE DERIVATIVES | SAMSUNG FINE CHEMICALS CO LTD (KR) | 2003-10-22 | — | — | EP | disclosed |
| US-6613944-B2 | Reacting phthalimide with an epoxide in the presence of potassium phthalimide in DMF or DMAC to give a phthalimide alkylalcohol, deacylation with aqueous acid | PHARMACIA & UPJOHN COMPANY | 2003-09-02 | — | — | US | disclosed |
| EP-1328509-A1 | METHODS OF PRODUCING OXAZOLIDINONE COMPOUNDS | Pharmacia & Upjohn Company (US) | 2003-07-23 | — | — | EP | disclosed |
| US-20030130509-A1 | PROCESS TO PRODUCE 3-CARBON AMINO ALCOHOL SALTS | PHARMACIA & UPJOHN COMPANY | 2003-07-10 | — | — | US | disclosed |
| US-6563003-B2 | The present invention includes a number of novel intermediates such as the (S)-secondary alcohol of formula (VIIIA) X2-CH2-C*H(OH)-CH2-NH-CO-RN (VIIIA) and processes for production of pharmacologically useful oxazolidinones. | PHARMACIA & UPJOHN COMPANY | 2003-05-13 | — | — | US | disclosed |
| US-20030065219-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY | 2003-04-03 | — | — | US | disclosed |
| US-20020169312-A1 | Process to prepare oxazolidinones | PHARMACIA & UPJOHN COMPANY | 2002-11-14 | — | — | US | disclosed |
| WO-2002085849-A2 | PROCESS TO PREPARE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 2002-10-31 | — | — | WO | disclosed |
| US-6417403-B1 | AMINATION OF 3,4-DISUBSTITUTED-1-BUTANECARBONYL DERIVATIVE THROUGH CURTIUS OR HOFMAN REARRANGEMENT; SALT FORMATION, CARBAMYLATION | SAMSUNG FINE CHEMICALS CO., LTD. (KR) | 2002-07-09 | — | — | US | disclosed |
| US-6410788-B1 | BACTERICIDES; REACTING IMINE, CARBAMATE, ESTER, AMIDE AND EPOXIDE DERIVATIVES | PHARMACIA & UPJOHN COMPANY | 2002-06-25 | — | — | US | disclosed |
| WO-2002032857-A1 | METHODS OF PRODUCING OXAZOLIDINONE COMPOUNDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-04-25 | — | — | WO | disclosed |
| US-6362334-B1 | OXAZOLIDINONE PHTHALAMIDE | PHARMACIA & UPJOHN COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-20020032348-A1 | Process to produce oxazolidinones | PEARLMAN BRUCE ALLEN (US) | 2002-03-14 | — | — | US | disclosed |
| CN-1301248-A | Process for preparing chiral (S)-2, 3-disubstituted-1-propylamine derivatives | SAMSUNG FINE CHEMICALS CO LTD (KR) | 2001-06-27 | — | — | CN | disclosed |
| EP-1071654-A1 | A PROCESS FOR PREPARING CHIRAL (S)-2,3-DISUBSTITUTED-1-PROPYLAMINE DERIVATIVES | Samsung Fine Chemicals Co., Ltd. (KR) | 2001-01-31 | — | — | EP | disclosed |
| EP-1028940-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| US-6107519-A | Process to produce oxazolidinones | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| WO-1999052855-A1 | A PROCESS FOR PREPARING CHIRAL (S)-2,3-DISUBSTITUTED-1-PROPYLAMINE DERIVATIVES | SAMSUNG FINE CHEMICALS CO., LTD. (KR) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999024393-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999024393-A1 | PROCESS TO PRODUCE OXAZOLIDINONES | PHARMACIA & UPJOHN COMPANY (US) | 1999-05-20 | — | — | WO | disclosed |