Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL1536 | 0.96 | NAPRT (0.69) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL29358144 | 0.96 | NAPRT (0.69) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL8398481 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL8398488 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL3801086 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL2810359 | 0.84 | — | — | |
| Pyridine SCHEMBL8733404 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL11673636 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL3706898 | 0.84 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMMEN1 | |
| Pyridine SCHEMBL23609 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111995587-A | 1, 4-disubstituted 3, 4-dihydro-2 (3H) -quinazolinone compound and synthetic method and application thereof | 上海工程技术大学 | 2020-11-27 | — | — | CN | claimed |
| CN-108273510-B | Z-shaped visible light response composite photocatalyst and preparation method thereof | 三明学院 | 2020-06-30 | — | — | CN | claimed |
| CN-108273510-A | A kind of visible light-responded composite photo-catalyst of Z-type and preparation method thereof | 三明学院 | 2018-07-13 | — | — | CN | claimed |
| CN-102603631-B | A kind of intermediate, preparation method and use of synthesis (-)-selagine | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) | 2016-04-13 | — | — | CN | claimed |
| CN-101412706-B | Novel method for preparing 1,3-dihydroxy acetone from glycerol | UNIV ZHEJIANG TECHNOLOGY | 2012-11-14 | — | — | CN | claimed |
| CN-102603631-A | Intermediate for synthetizing (-)-huperzine A, synthetic method and application | SHANGHAI INST ORGANIC CHEM | 2012-07-25 | — | — | CN | claimed |
| CN-101805389-A | Preparation method of corosolic acid | HUBEI YITAI PHARMACEUTICAL CO LTD | 2010-08-18 | — | — | CN | claimed |
| CN-101412706-A | Novel method for preparing 1,3-dihydroxy acetone from glycerol | UNIV ZHEJIANG TECHNOLOGY (CN) | 2009-04-22 | — | — | CN | claimed |
| CN-101020682-A | Synthesis process of 6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-formaldehyde | UNIV ZHEJIANG (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-1232493-C | Synthesis process of methoxy citronellal | GUANGZHOU INST CHEMISTRY CAS (CN) | 2005-12-21 | — | — | CN | claimed |
| CN-1208293-C | Alkyl cyclohexyl alkyne type liquid crystal and its production process | UNIV TSINGHUA (CN) | 2005-06-29 | — | — | CN | claimed |
| CN-1560009-A | Synthesis process of methoxy citronellal | 中国科学院广州化学研究所 | 2005-01-05 | — | — | CN | claimed |
| CN-1037710-A | The method of synthetic oil analogue of rape lactone | UNIV YUNNAN (CN) | 1989-12-06 | — | — | CN | claimed |
| CN-115850035-B | Spice synthesized from 1, 8-terpene diol and process thereof | 广西壮族自治区林业科学研究院 | 2024-05-17 | — | — | CN | disclosed |
| CN-114213230-B | Method for preparing 1, 3-dihydroxyacetone | 山东师范大学 | 2024-03-01 | — | — | CN | disclosed |
| CN-116947903-A | Inhibitors of complement factors and uses thereof | 安尼艾克松股份有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-1347418-A | Novel nucleosides and oligonucleotide analogues | SANKYO CO (JP) | 2002-05-01 | — | — | CN | disclosed |
| CN-1027976-C | Method for synthesizing brassinolide analogue | YUNAN UNIV (CN) | 1995-03-22 | — | — | CN | disclosed |
| CN-1054976-A | Bulleyaconitine A and analogous alkaloid preparation thereof | UNIV YUNNAN (CN) | 1991-10-02 | — | — | CN | disclosed |
| CN-1037710-A | The method of synthetic oil analogue of rape lactone | UNIV YUNNAN (CN) | 1989-12-06 | — | — | CN | disclosed |