Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.67 |
| ▸ | TTR known ✓ | P02766 | 1/20 | 0.58 |
| ▸ | EDNRA known ✓ | P25101 | 7/20 | 0.54 |
| ▸ | HDAC4 known ✓ | P56524 | 1/20 | 0.50 |
| ▸ | HDAC10 known ✓ | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC5 known ✓ | Q9UQL6 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 3/20 | 0.60 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.60 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.60 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133520 | 0.98 | CA2 (0.69) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29367067 | 0.98 | CA2 (0.69) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL29941705 | 0.98 | CA2 (0.69) | CA2F2PRSS1PRSS2PRSS3 | |
| Fluoride SCHEMBL27590191 | 0.96 | CA2 (0.67) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2131462 | 0.96 | CA2 (0.67) | CA2F2PRSS1PRSS2PRSS3 | |
| Water SCHEMBL29242598 | 0.96 | CA2 (0.67) | CA2F2PRSS1PRSS2PRSS3 | |
| Nitrogen SCHEMBL2132642 | 0.95 | CA2 (0.65) | CA2F2PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL28302238 | 0.88 | CA2 (0.54) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL28056727 | 0.87 | CA2 (0.54) | CA2F2PRSS1PRSS2PRSS3 | |
| SCHEMBL6129742 | 0.84 | CA2 (0.65) | CA2F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110168111-A | Method and apparatus for detecting Hepatitis C Virus | 奎斯特诊断投资有限责任公司 | 2019-08-23 | — | — | CN | claimed |
| CN-1151793-A | Complex combinatorial chemical libraries encoded with tags | UNIV COLUMBIA (US) | 1997-06-11 | — | — | CN | claimed |
| CN-114450298-A | Interleukin-2 formulations and uses thereof | 威特拉公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-114269786-A | CD138 humanized antibody molecules and uses thereof | 威特拉公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-111183157-A | CD138 antibody molecules and uses thereof | 威特拉公司 | 2020-05-19 | — | — | CN | disclosed |
| CN-107533060-B | Combine treponema and the test of non-treponema syphilis | 生物辐射实验室股份有限公司 | 2019-11-05 | — | — | CN | disclosed |
| CN-110268247-A | Measurement of protein-protein interactions at the Single molecule level | 生物辐射实验室股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-110199019-A | Analysis of Macromolecules Using Nucleic Acid Encoding | ENCODIA有限公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-110168367-A | Biological thiol detection combination object comprising redox regulatory protein | 汉阳大学校产学协力团 | 2019-08-23 | — | — | CN | disclosed |
| CN-110168111-A | Method and apparatus for detecting Hepatitis C Virus | 奎斯特诊断投资有限责任公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105143885-B | The photosensitizer chemical bleaching of dyestuff | 通用电气医疗集团生物科学公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-101573139-A | Methods for improving immune function and methods for prevention or treatment of disease in a mammalian subject | NASCENT BIOLOG INC (US) | 2009-11-04 | — | — | CN | disclosed |
| CN-101283270-A | Holder for analysis and use thereof | IBIDEN CO LTD (JP) | 2008-10-08 | — | — | CN | disclosed |
| CN-101199241-A | Apparatus and method for molecular analysis | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2008-06-11 | — | — | CN | disclosed |
| CN-1326519-C | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2007-07-18 | — | — | CN | disclosed |
| CN-1602191-A | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase | NOVO NORDISK AS (DK) | 2005-03-30 | — | — | CN | disclosed |
| CN-1518445-A | Treatment of sexual dysfunction | 沃纳-兰伯特公司 | 2004-08-04 | — | — | CN | disclosed |
| CN-1479618-A | Treatment of sexual dysfunction with bombesin antagonists | ����-�����ع�˾ | 2004-03-03 | — | — | CN | disclosed |
| CN-1121200-C | Cosmetic composition for rejuvenation of skin without skin irratation | ISP INVESTMENTS INC (US) | 2003-09-17 | — | — | CN | disclosed |
| CN-1151793-A | Complex combinatorial chemical libraries encoded with tags | UNIV COLUMBIA (US) | 1997-06-11 | — | — | CN | disclosed |