Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trimethylammonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimethylammonium SCHEMBL332711 | 0.98 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL6416933 | 0.98 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL27578413 | 0.98 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL421649 | 0.96 | THRB (0.57) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL28463491 | 0.93 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL31612653 | 0.93 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL7150631 | 0.93 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Trimethylammonium SCHEMBL31612657 | 0.93 | THRB (0.55) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Hydrochloric Acid SCHEMBL6821105 | 0.93 | THRB (0.59) | THRBTSHRALDH1A1LMNAHSD17B10 | |
| Methacrylic Acid SCHEMBL5987967 | 0.92 | THRB (0.50) | THRBTSHRALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107487830-B | Star-shaped copolymer sewage treatment agent with cyclodextrin as core and RAFT preparation method thereof | 内蒙古信尚环保科技有限公司 | 2021-06-15 | — | — | CN | claimed |
| CN-108824035-A | A kind of fabrics printing and dyeing color fixing agent and preparation method thereof | 陈国宝 | 2018-11-16 | — | — | CN | claimed |
| CN-100347256-C | Composite compositions of co-structured or co-adsorbed organic or mineral pigments or fillers and their uses | PLUSS STAUFFER AG (CH) | 2007-11-07 | — | — | CN | claimed |
| CN-1322876-A | Prepn of water soluble quarternary copolymer softener | GUANGDONG AIQIMEI SCIENCE & TE (CN) | 2001-11-21 | — | — | CN | claimed |
| CN-1299400-A | Composite compositions of co-structured or co-adsorbed organic or mineral pigments or fillers and their uses | PLUSS STAUFFER AG (CH) | 2001-06-13 | — | — | CN | claimed |
| CN-107487830-B | Star-shaped copolymer sewage treatment agent with cyclodextrin as core and RAFT preparation method thereof | 内蒙古信尚环保科技有限公司 | 2021-06-15 | — | — | CN | disclosed |
| CN-107804906-B | Preparation method of star-shaped copolymer flocculant with POSS as center | 湖南辰砾新材料有限公司 | 2021-05-14 | — | — | CN | disclosed |
| CN-111892145-A | Star-shaped copolymer flocculant with POSS as center | 湖南辰砾新材料有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111892146-A | Application method of star-shaped copolymer flocculant with POSS as center | 湖南辰砾新材料有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-108824035-A | A kind of fabrics printing and dyeing color fixing agent and preparation method thereof | 陈国宝 | 2018-11-16 | — | — | CN | disclosed |
| CN-107501474-A | A kind of Polyacrylamide Grafted chitosan comb copolymer sewage-treating agent and its RAFT preparation methods | 杨文思 | 2017-12-22 | — | — | CN | disclosed |
| CN-107487830-A | A kind of star copolymer sewage-treating agent and its RAFT using cyclodextrin as core prepares method | 杨文思 | 2017-12-19 | — | — | CN | disclosed |
| CN-100347256-C | Composite compositions of co-structured or co-adsorbed organic or mineral pigments or fillers and their uses | PLUSS STAUFFER AG (CH) | 2007-11-07 | — | — | CN | disclosed |
| CN-1260425-C | Prepn of water soluble quarternary copolymer softener | GUANGZHOU NUOKAI TRADE CO LTD (CN) | 2006-06-21 | — | — | CN | disclosed |
| CN-1322876-A | Prepn of water soluble quarternary copolymer softener | GUANGDONG AIQIMEI SCIENCE & TE (CN) | 2001-11-21 | — | — | CN | disclosed |
| CN-1299400-A | Composite compositions of co-structured or co-adsorbed organic or mineral pigments or fillers and their uses | PLUSS STAUFFER AG (CH) | 2001-06-13 | — | — | CN | disclosed |