Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 4/20 | 0.60 |
| ▸ | ESR2 known ✓ | Q92731 | 4/20 | 0.60 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.46 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.34 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.32 |
| ▸ | GLA known ✓ | P06280 | 1/20 | 0.32 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27589494 | 1.00 | TDP1 (0.86) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL288031 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL447754 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL28386435 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL9414432 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Benzene SCHEMBL11521546 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Phosphine SCHEMBL480827 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL8372285 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL288029 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E | |
| Hydrochloric Acid SCHEMBL1584554 | 0.96 | TDP1 (0.92) | TDP1CYP3A4ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108546409-A | A kind of caoutchouc elasticity gasket material and preparation method thereof | 繁昌县凯相智能装备有限公司 | 2018-09-18 | — | — | CN | claimed |
| CN-108493468-A | A kind of epoxy polyphenylene oxide proton membrane and preparation method thereof | 温州市赢创新材料技术有限公司 | 2018-09-04 | — | — | CN | claimed |
| CN-106243812-A | A kind of based on amido silicon oil creep into drilling rod protective coating and preparation method thereof | 江苏和信石油机械有限公司 | 2016-12-21 | — | — | CN | claimed |
| CN-106189774-A | A kind of based on polyurethane resin creep into drilling rod protective coating and preparation method thereof | 吴旭丹 | 2016-12-07 | — | — | CN | claimed |
| CN-106084941-A | A kind of based on acrylic resin creep into drilling rod protective coating and preparation method thereof | 曾冰冰 | 2016-11-09 | — | — | CN | claimed |
| CN-109912651-A | A kind of preparation method of benzyl triphenyl phosphonium chloride phosphine | 自贡天龙化工有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109501415-A | The adhesive plaster material of chemically infiltration with polyester-cotton blend liner | 山西新华化工有限责任公司 | 2019-03-22 | — | — | CN | disclosed |
| CN-109397816-A | Overlay film protective rubber cloth material | 山西新华化工有限责任公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109401138-A | The adhesive plaster material of poly-blended rubber coated fabrics | 山西新华化工有限责任公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109403057-A | Low temperature resistant fluorubber coats fabric | 山西新华化工有限责任公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-108546409-A | A kind of caoutchouc elasticity gasket material and preparation method thereof | 繁昌县凯相智能装备有限公司 | 2018-09-18 | — | — | CN | disclosed |
| CN-108546409-A | A kind of caoutchouc elasticity gasket material and preparation method thereof | 繁昌县凯相智能装备有限公司 | 2018-09-18 | — | — | CN | disclosed |
| CN-106085167-A | A kind of based on nano titanium oxide creep into drilling rod protective coating and preparation method thereof | 吴舒晨 | 2016-11-09 | — | — | CN | disclosed |
| CN-106084941-A | A kind of based on acrylic resin creep into drilling rod protective coating and preparation method thereof | 曾冰冰 | 2016-11-09 | — | — | CN | disclosed |
| CN-100489027-C | Flame-retardant epoxy resin composition and phosphorus-containing compound | CHANGCHUN ARTIFICIAL RESIN FAC (CN) | 2009-05-20 | — | — | CN | disclosed |
| CN-100475912-C | Halogen-free resin composition | CHANG CHUN PLASTICS CO LTD (CN) | 2009-04-08 | — | — | CN | disclosed |
| CN-1285578-C | Substituted benzoic acid amides and their use in inhibiting angiogenesis | SCHERING AG (DE) | 2006-11-22 | — | — | CN | disclosed |
| CN-1580128-A | Halogen-free resin composition | CHANGCHUN ARTIFICIAL RESIN FAC (CN) | 2005-02-16 | — | — | CN | disclosed |
| CN-1580120-A | Flame-retardant epoxy resin composition and phosphorus-containing compound | CHANGCHUN ARTIFICIAL RESIN FAC (CN) | 2005-02-16 | — | — | CN | disclosed |
| CN-1426396-A | Substituted benzoic acid amides and use for inhibition of angiogenesis thereof | SCHERING AG (DE) | 2003-06-25 | — | — | CN | disclosed |