Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dyrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 known ✓ | Q9UBN7 | 1/20 | 0.45 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.43 |
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyrene SCHEMBL8881784 | 1.00 | TSHR (0.96) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL827164 | 1.00 | TSHR (0.96) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL3326806 | 1.00 | TSHR (0.96) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL29364667 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL1903290 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL6750152 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL133054 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL8166670 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL13280 | 0.98 | TSHR (1.00) | TSHRNFKB1MAPTKMT2AKDM4E | |
| Dyrene SCHEMBL5745643 | 0.96 | TSHR (0.96) | TSHRNFKB1MAPTKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9700632-B2 | Dendrimers, conjugates and methods thereof | CENTRE FOR BIOSEPERATION TECHNOLOGY-VIT (IN) | 2017-07-11 | — | — | US | claimed |
| US-20150238623-A1 | Dendrimers, Conjugates and Methods Thereof | CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT (IN) | 2015-08-27 | — | — | US | claimed |
| WO-2014041517-A2 | DENDRIMERS, CONJUGATES AND METHODS THEREOF | CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT (IN) | 2014-03-20 | — | — | WO | claimed |
| US-6806284-B1 | Photosensitizers with ligand targeting properties for tumor therapy | CERAM OPTEC INDUSTRIES, INC. | 2004-10-19 | — | — | US | claimed |
| JP-56026925-A | — | — | None | — | — | JP | disclosed |
| US-9700632-B2 | Dendrimers, conjugates and methods thereof | CENTRE FOR BIOSEPERATION TECHNOLOGY-VIT (IN) | 2017-07-11 | — | — | US | disclosed |
| CN-105175409-A | Triazine Derivatives and their Therapeutical Applications | CALIFORNIA CAPITAL EQUITY LLC | 2015-12-23 | — | — | CN | disclosed |
| US-20150238623-A1 | Dendrimers, Conjugates and Methods Thereof | CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT (IN) | 2015-08-27 | — | — | US | disclosed |
| CN-102573485-B | triazine derivatives and their therapeutic use | ABRAXIS BIOSCIENCE LLC | 2014-11-26 | — | — | CN | disclosed |
| WO-2014041517-A2 | DENDRIMERS, CONJUGATES AND METHODS THEREOF | CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT (IN) | 2014-03-20 | — | — | WO | disclosed |
| EP-2562864-A1 | Proton-conducting polymer | Nippon Steel Chemical Co., Ltd. (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-8198387-B2 | Proton-conducting compound and proton-conducting polymer | NIPPON STEEL CHEMICAL CO., LTD. (JP) | 2012-06-12 | — | — | US | disclosed |
| WO-1989007957-A1 | CO2 INDICATOR FOR PLACEMENT OF TRACHEAL TUBES | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-09-08 | — | — | WO | disclosed |
| EP-0316492-A1 | Polymeric matrix for affinity chromatography and immobilization of ligands | BIOPROBE INTERNATIONAL, INC. (US) | 1989-05-24 | — | — | EP | disclosed |
| US-4753983-A | Polymeric matrix for affinity chromatography and immobilization of ligands | BIOPROBE INTERNATIONAL, INC. (US) | 1988-06-28 | — | — | US | disclosed |
| EP-0184361-A2 | Method of activating polymeric carrier | BIOPROBE INTERNATIONAL, INC. (US) | 1986-06-11 | — | — | EP | disclosed |
| JP-S5626925-A | PRODUCTION OF EPOXY RESIN | SUMITOMO CHEM CO LTD | 1981-03-16 | — | — | JP | disclosed |
| US-4245107-A | ANTIBIOTICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-01-13 | — | — | US | disclosed |
| US-4229573-A | BACTERICIDES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1980-10-21 | — | — | US | disclosed |
| US-4172197-A | BACTERICIDES | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1979-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150238623-A1 | Dendrimers, Conjugates and Methods Thereof | PAICS, CD2BP2, CD44 | HDAC3 1262/4885HDAC1 2287/4885HDAC2 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.