Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA known ✓ | P10253 | 4/20 | 0.57 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.50 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.50 |
| ▸ | CYP19A1 known ✓ | P11511 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31723405 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| Hydrochloric Acid SCHEMBL11803962 | 1.00 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| SCHEMBL29389101 | 0.98 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| SCHEMBL15514306 | 0.98 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| SCHEMBL212391 | 0.98 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| SCHEMBL11514774 | 0.95 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| Water SCHEMBL11435527 | 0.95 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| Hydrogen Sulfide SCHEMBL28337763 | 0.95 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| Water SCHEMBL6445920 | 0.95 | ALDH1A1 (0.61) | ALDH1A1MAPTMEN1KMT2ATHRB | |
| Methyl Alcohol SCHEMBL28031053 | 0.93 | ALDH1A1 (0.59) | ALDH1A1MAPTMEN1KMT2ATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1970704-B1 | REAGENT FOR MEASURING AGGREGATION AND METHOD OF MEASURING AGGREGATION | SEKISUI MEDICAL CO LTD (JP) | 2016-07-13 | — | — | EP | claimed |
| US-8987005-B2 | Reagent for measuring agglutination and method of measuring agglutination | SEKISUI MEDICAL CO., LTD. (JP) | 2015-03-24 | — | — | US | claimed |
| US-20100167310-A1 | Reagent for Measuring Agglutination and Method of Measuring Agglutination | SEKISUI MEDICAL CO., LTD. (JP) | 2010-07-01 | — | — | US | claimed |
| CN-101351707-A | Reagent for measuring agglutination and method for measuring agglutination | SEKISUI MEDICAL CO LTD (JP) | 2009-01-21 | — | — | CN | claimed |
| EP-1970704-A1 | REAGENT FOR MEASURING AGGREGATION AND METHOD OF MEASURING AGGREGATION | Sekisui Medical Co., Ltd. (JP) | 2008-09-17 | — | — | EP | claimed |
| US-20220034909-A1 | METHOD AND KIT FOR QUANTIFYING LIVER-TYPE FATTY ACID BINDING PROTEIN, METHOD AND KIT FOR TESTING FOR KIDNEY DISEASES, AND COMPANION DIAGNOSTIC DRUG | CMIC HOLDINGS CO., LTD. (JP) | 2022-02-03 | — | — | US | disclosed |
| CN-112805565-A | Method for quantifying liver-type fatty acid binding protein, kit for quantifying same, method for detecting renal disease, kit for detecting same, and diagnostic agent for same | CMIC控股有限公司 | 2021-05-14 | — | — | CN | disclosed |
| CN-112771377-A | Method for examining liver disease, examination kit therefor, and diagnostic agent therefor | CMIC控股有限公司 | 2021-05-07 | — | — | CN | disclosed |
| WO-2020067472-A1 | METHOD FOR TESTING FOR LIVER DISEASE, TEST KIT THEREFOR, AND COMPANION DIAGNOSTIC AGENT | シミックホールディングス株式会社 | 2020-04-02 | — | — | WO | disclosed |
| WO-2020067471-A1 | METHOD AND KIT FOR QUANTIFYING LIVER-TYPE FATTY ACID BINDING PROTEIN, METHOD AND KIT FOR TESTING FOR KIDNEY DISEASES, AND COMPANION DIAGNOSTIC DRUG | シミックホールディングス株式会社 | 2020-04-02 | — | — | WO | disclosed |
| EP-1970704-B1 | REAGENT FOR MEASURING AGGREGATION AND METHOD OF MEASURING AGGREGATION | SEKISUI MEDICAL CO LTD (JP) | 2016-07-13 | — | — | EP | disclosed |
| US-8987005-B2 | Reagent for measuring agglutination and method of measuring agglutination | SEKISUI MEDICAL CO., LTD. (JP) | 2015-03-24 | — | — | US | disclosed |
| EP-0011048-A1 | A process for the manufacture of substantially pure 3-amino-4-alkoxy-acylanilides from 2,4-dinitrochlorobenzene | Toms River Chemical Corporation (US) | 1980-05-14 | — | — | EP | disclosed |
| US-4097450-A | REPAIRING NARROW CREVICE IN NICKEL-BASE SUPERALLOY | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-27 | — | — | US | disclosed |
| US-4093640-A | HAIR DYES | L'OREAL (FR) | 1978-06-06 | — | — | US | disclosed |
| US-4065255-A | HUMAN HAIR | L'OREAL (FR) | 1977-12-27 | — | — | US | disclosed |
| US-4008999-A | N,N-dialkylamino diphenylamines for dyeing keratinic fibers | SOCIETE ANONYME DITE: L'OREAL (FR) | 1977-02-22 | — | — | US | disclosed |
| US-3984443-A | Indamines for dyeing keratinic fibers | L'OREAL (FR) | 1976-10-05 | — | — | US | disclosed |
| US-3984402-A | Indoanilines for dyeing keratinous fibers | L'OREAL (FR) | 1976-10-05 | — | — | US | disclosed |
| US-3981678-A | HAIR DYES | L'OREAL (FR) | 1976-09-21 | — | — | US | disclosed |