Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A known ✓ | P35499 | 1/20 | 0.30 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A known ✓ | Q15858 | 1/20 | 0.30 |
| ▸ | FBP1 | P09467 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28153301 | 1.00 | — | — | |
| SCHEMBL553587 | 0.97 | — | — | |
| SCHEMBL27574882 | 0.94 | — | — | |
| SCHEMBL818125 | 0.94 | — | — | |
| SCHEMBL27592975 | 0.94 | — | — | |
| SCHEMBL24029377 | 0.94 | ACHE (0.35) | FBP1LMNATSHRMAPK1SCN4A | |
| SCHEMBL817368 | 0.94 | — | — | |
| SCHEMBL818724 | 0.94 | — | — | |
| SCHEMBL817907 | 0.94 | — | — | |
| Furan SCHEMBL28253766 | 0.82 | MAPK1 (0.38) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109824609-A | A method of preparing pyrazinamide | 浙江海洲制药有限公司 | 2019-05-31 | — | — | CN | claimed |
| CN-107249691-A | Polypharmacy for tuberculosis treatment | 加利福利亚大学董事会 | 2017-10-13 | — | — | CN | claimed |
| CN-105861694-A | Biomarker for predicating idiosyncratic liver injuries of child patients and application of biomarker | 中南大学湘雅三医院 | 2016-08-17 | — | — | CN | claimed |
| CN-110201091-A | It is a kind of to treat tuberculosis composition | 高艳萍 | 2019-09-06 | — | — | CN | disclosed |
| CN-105640925-B | Dried powder formula and method for treating pulmonary disease | 普马特里克斯营业公司 | 2019-08-16 | — | — | CN | disclosed |
| CN-110003253-A | Tricyclic benzoxaborole heterocyclic pentene compound and application thereof | 葛兰素史克知识产权第二有限公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-109923111-A | ANTIBIOTIC COMPOUNDS | 迪斯库瓦有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-105924380-B | Luxuriant and rich with fragrance class compound or derivatives thereof and treatment medicine for tuberculosis compositions containing the phenanthrene class compound or derivatives thereof | 顺天乡大学校产学协力团 | 2019-03-05 | — | — | CN | disclosed |
| CN-105492388-B | Tricyclic benzoxaborole compounds and uses thereof | 葛兰素史克知识产权第二有限公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108949949-A | Drug transporter gene polymorphism sites relevant to anti-tubercular drug physical property hepatic injury generation and its application | 上海市预防医学研究院 | 2018-12-07 | — | — | CN | disclosed |
| CN-108949948-A | GSTA gene polymorphism sites relevant to anti-tubercular drug physical property hepatic injury generation and its application | 上海市预防医学研究院 | 2018-12-07 | — | — | CN | disclosed |
| CN-107096014-A | Monovalent metal cation dry powder doses are used in suction | 普马特里克斯营业公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107074879-A | Novel cytotoxic molecules for use in cell binding molecule-drug conjugates | 杭州多禧生物科技有限公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-107058527-A | SNP mark, kit and the application related to the reaction of antituberculotic hepatotoxicity wind agitation based on KCNE3 and NAT2 genes | 北京光大隆泰科技有限责任公司 | 2017-08-18 | — | — | CN | disclosed |
| CN-107043817-A | SNP mark, kit and the application related to the reaction of antituberculotic hepatotoxicity wind agitation based on CAMTA1 genes | 北京光大隆泰科技有限责任公司 | 2017-08-15 | — | — | CN | disclosed |
| CN-106868163-A | The SNP mark related to the reaction of antituberculotic hepatotoxicity wind agitation, kit and application based on FLT3 and NAT2 genes | 北京光大隆泰科技有限责任公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106868161-A | The SNP mark related to the reaction of antituberculotic hepatotoxicity wind agitation, kit and application based on BLNK and NAT2 genes | 北京光大隆泰科技有限责任公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106868162-A | The SNP mark related to the reaction of antituberculotic hepatotoxicity wind agitation, kit and application based on PPP2R2B and NAT2 genes | 北京光大隆泰科技有限责任公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-106631626-A | Pyrazinamide-adding biological phosphate fertilizer for waxberries | 苏州市相城区石新苗木产销专业合作社 | 2017-05-10 | — | — | CN | disclosed |
| CN-105950726-A | Mycobacterium tuberculosis pyrazinamide molecule drug sensitivity detection method | 杭州市疾病预防控制中心 | 2016-09-21 | — | — | CN | disclosed |