Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.37 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.37 |
| ▸ | ITGB3 known ✓ | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B known ✓ | P08514 | 1/20 | 0.33 |
| ▸ | MMP1 known ✓ | P03956 | 1/20 | 0.32 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.32 |
| ▸ | GGT1 | P19440 | 2/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372593 | 0.98 | GGT1 (0.42) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| SCHEMBL6552817 | 0.98 | GGT1 (0.42) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Hydrochloric Acid SCHEMBL28113514 | 0.96 | GGT1 (0.39) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Hydrochloric Acid SCHEMBL28232525 | 0.96 | GGT1 (0.39) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| SCHEMBL28094429 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Bromide SCHEMBL30125547 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Methane SCHEMBL28148285 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Potassium SCHEMBL30918640 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| SCHEMBL28160153 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 | |
| Phosphine SCHEMBL28013169 | 0.96 | GGT1 (0.41) | GGT1NOD1CHRM1AKR1A1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107047634-A | A kind of composite pesticide for the broccoli prevention and control of plant diseases, pest control | 安徽云中生态农业开发有限公司 | 2017-08-18 | — | — | CN | claimed |
| CN-106729813-A | The method that microwave sterilization is carried out to rhizoma Gastrodiae | 四川金岁方药业有限公司 | 2017-05-31 | — | — | CN | claimed |
| CN-106470697-B | Anti-EGFR antibodies and uses thereof | 兴盟生物医药(苏州)有限公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-109810961-B | A- amylase mutant and its encoding gene and their application for high concentration starch liquefacation | 中粮集团有限公司 | 2019-10-18 | — | — | CN | disclosed |
| CN-107446020-B | Folacin receptor alpha specific peptide 2 and its application | 中国药科大学 | 2019-10-01 | — | — | CN | disclosed |
| CN-109867772-A | A kind of high molecular weight degradable polyethylene glycol and its synthetic method and application | 浙江大学 | 2019-06-11 | — | — | CN | disclosed |
| CN-109810961-A | A- amylase mutant and its encoding gene and their application for high concentration starch liquefacation | 中粮集团有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-109689876-A | Method for producing alcohols under aerobic conditions and for extracting products using oleyl alcohol | 赢创德固赛有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109485729-A | Binding molecules for BCMA and CD3 | 安进研发（慕尼黑）股份有限公司 | 2019-03-19 | — | — | CN | disclosed |
| CN-109321532-A | It is a kind of for detecting the double-antibody sandwich elisa detection kit and its application of goat haemadsorption virus 1 | 江苏省农业科学院 | 2019-02-12 | — | — | CN | disclosed |
| CN-105758942-B | Polyprotein based on multiple nucleic acids aptamer while on-line preconcentration detection method | 中国科学院大连化学物理研究所 | 2019-01-04 | — | — | CN | disclosed |
| CN-107446020-A | Folacin receptor alpha specific WPFAHWPWQYPR and its application | 中国药科大学 | 2017-12-08 | — | — | CN | disclosed |
| CN-107389938-A | A kind of head-shaking pill detection method based on biomembrane interference technique | 浙江警察学院 | 2017-11-24 | — | — | CN | disclosed |
| CN-107353325-A | Folacin receptor alpha specific WHWTNWGKTSPA and its application | 中国药科大学 | 2017-11-17 | — | — | CN | disclosed |
| CN-107345966-A | A kind of methadone detection method based on biomembrane interference technique | 浙江警察学院 | 2017-11-14 | — | — | CN | disclosed |
| CN-106996923-A | The method that a variety of environmental hormones are detected based on the surface plasma resonance technology that regenerated liquid optimizes simultaneously | 丁利 | 2017-08-01 | — | — | CN | disclosed |
| CN-106939041-A | The method that Recombinant Naja naja atra NGF is purified using polyclonal antibody affinity column | 奔驰生物科技（云南）有限公司 | 2017-07-11 | — | — | CN | disclosed |
| CN-106699848-A | Polypeptide specially combined with activated hepatic stellate cells and preparation method and application thereof | 贵州医科大学 | 2017-05-24 | — | — | CN | disclosed |
| CN-105980406-A | BINDING MOLECULES FOR BCMA AND CD3 | 安进研发（慕尼黑）股份有限公司 | 2016-09-28 | — | — | CN | disclosed |
| CN-104274469-B | A kind of pharmaceutical composition containing Fasudic hydrochloride | 长春海悦药业股份有限公司 | 2016-08-31 | — | — | CN | disclosed |