Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Histidinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidinol SCHEMBL27808360 | 1.00 | — | — | |
| Histidinol SCHEMBL370912 | 1.00 | — | — | |
| Histidinol SCHEMBL65205 | 0.98 | — | — | |
| Histidinol SCHEMBL1580900 | 0.98 | — | — | |
| Histidinol SCHEMBL65204 | 0.98 | — | — | |
| Histidinol SCHEMBL29723310 | 0.98 | — | — | |
| Histidinol SCHEMBL28178828 | 0.96 | — | — | |
| Histidinol SCHEMBL29001880 | 0.96 | — | — | |
| Histidinol SCHEMBL28190716 | 0.91 | ALPI (0.31) | — | |
| Histidinol SCHEMBL1392278 | 0.90 | LAP3 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300488-B1 | CELL LYSIS REAGENT FOR ISOLATION OF RNA | BIO RAD LABORATORIES (US) | 2014-03-19 | — | — | EP | claimed |
| US-8357672-B2 | Cell lysis reagent for isolation of RNA | BIO-RAD LABORATORIES, INC. (US) | 2013-01-22 | — | — | US | claimed |
| JP-2011524360-A | — | — | 2011-09-01 | — | — | JP | claimed |
| EP-2300488-A1 | CELL LYSIS REAGENT FOR ISOLATION OF RNA | Bio-Rad Laboratories, Inc. (US) | 2011-03-30 | — | — | EP | claimed |
| EP-2173874-A2 | METHODS FOR ISOLATING LONG FRAGMENT RNA FROM FIXED SAMPLES | Response Genetics, Inc (US) | 2010-04-14 | — | — | EP | claimed |
| US-20090317894-A1 | CELL LYSIS REAGENT FOR ISOLATION OF RNA | BIO-RAD LABORATORIES, INC. (US) | 2009-12-24 | — | — | US | claimed |
| WO-2009152204-A1 | CELL LYSIS REAGENT FOR ISOLATION OF RNA | BIO-RAD LABORATORIES, INC. (US) | 2009-12-17 | — | — | WO | claimed |
| US-20090092979-A1 | METHODS FOR ISOLATING LONG FRAGMENT RNA FROM FIXED SAMPLES | RESPONSE GENETICS, INC. (US) | 2009-04-09 | — | — | US | claimed |
| WO-2009002937-A2 | METHODS FOR ISOLATING LONG FRAGMENT RNA FROM FIXED SAMPLES | RESPONSE GENETICS, INC (US) | 2008-12-31 | — | — | WO | claimed |
| US-20030204077-A1 | RNA isolation reagent and methods | INVITROGEN CORPORATION | 2003-10-30 | — | — | US | claimed |
| EP-1005479-A4 | RNA ISOLATION REAGENT AND METHODS | LIFE TECHNOLOGIES INC (US) | 2002-12-18 | — | — | EP | claimed |
| EP-1005479-A1 | RNA ISOLATION REAGENT AND METHODS | LIFE TECHNOLOGIES, INC. (US) | 2000-06-07 | — | — | EP | claimed |
| WO-1998045311-A1 | RNA ISOLATION REAGENT AND METHODS | LIFE TECHNOLOGIES, INC. (US) | 1998-10-15 | — | — | WO | claimed |
| CN-119185662-A | Programmable continuous chiral mineral gradient distribution material and application thereof | 上海市第六人民医院 | 2024-12-27 | — | — | CN | disclosed |
| WO-2024150597-A1 | THERMOSETTING RESIN COMPOSITION, CURED FILM, SUBSTRATE, AND ELECTRONIC COMPONENT | JNC株式会社 | 2024-07-18 | — | — | WO | disclosed |
| US-20240175044-A1 | HIGH GROWTH AND HIGH HARDINESS TRANSGENIC PLANTS | BIOLUMIC LIMITED (NZ) | 2024-05-30 | — | — | US | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| US-5290926-A | Herbicides | CIBA-GEIGY CORPORATION (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0478502-A2 | Histidinol dehydrogenase protein, DNA and muteins and transgenic plants thereof | CIBA-GEIGY AG (CH) | 1992-04-01 | — | — | EP | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |