Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 10/20 | 0.55 |
| ▸ | CHRM2 known ✓ | P08172 | 8/20 | 0.55 |
| ▸ | CHRM1 known ✓ | P11229 | 7/20 | 0.55 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.90 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.90 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8204903 | 0.98 | KEAP1 (0.93) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL6004238 | 0.98 | KEAP1 (0.93) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| Water SCHEMBL8898031 | 0.98 | KEAP1 (0.93) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL8197629 | 0.98 | KEAP1 (0.93) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL1235433 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL198082 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL3909615 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL2764243 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL7269393 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 | |
| SCHEMBL198312 | 0.96 | KEAP1 (0.96) | KEAP1NFE2L2POLBCHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700410-A | Method of manufacturing wax matrices | NIPPON SHINYAKU CO., LTD. (JP) | 1997-12-23 | — | — | US | claimed |
| US-8580305-B2 | Tablet quickly melting in oral cavity | NIPPON SHINYAKU CO., LTD. (JP) | 2013-11-12 | — | — | US | disclosed |
| EP-1323416-B1 | PROCESS FOR PRODUCING MEDICINAL SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 2010-12-22 | — | — | EP | disclosed |
| EP-1595533-B1 | TABLET QUICKLY MELTING IN ORAL CAVITY | NIPPON SHINYAKU CO LTD (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-20080299192-A1 | Intraorally Rapidly Disintergrating Tablets and Their Production | NIPPON SHINYAKU CO., LTD (JP) | 2008-12-04 | — | — | US | disclosed |
| EP-1411955-A4 | SUCRALOSE FORMULATIONS TO MASK UNPLEASANT TASTES | WYETH CORP (US) | 2006-07-05 | — | — | EP | disclosed |
| US-20060134199-A1 | Tablet quickly melting in oral cavity | NIPPON SHINYAKU CO., LTD. (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1365743-B1 | FAST DISSOLVING TABLETS | WYETH CORP (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1595533-A1 | TABLET QUICKLY MELTING IN ORAL CAVITY | Nippon Shinyaku Co., Ltd. (JP) | 2005-11-16 | — | — | EP | disclosed |
| WO-2005041884-A9 | POLYMER-BASED MICROSTRUCTURES | ENGINEERED RELEASE SYSTEMS INC (US) | 2005-06-23 | — | — | WO | disclosed |
| EP-0580861-B1 | Sustained release capsule for adhesion in the gastrointestinal tract | NIPPON SHINYAKU CO LTD (JP) | 1998-09-09 | — | — | EP | disclosed |
| EP-0580860-B1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU CO LTD (JP) | 1997-10-22 | — | — | EP | disclosed |
| EP-0717988-A1 | GASTRIC REMAINING PREPARATION, SWOLLEN MOLDING, AND PRODUCTION PROCESS | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1996-06-26 | — | — | EP | disclosed |
| US-5498422-A | WATER SOLUBLE POLYMERS, CARBOXYVINYL POLYMERS OR SODIUM POLYACRYLATES | NIPPON SHINYAKU COMPANY LIMITED (JP) | 1996-03-12 | — | — | US | disclosed |
| US-5456923-A | Produced without heating a drug and a polymer to or beyond their melting points and without using an organic solvent | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1995-10-10 | — | — | US | disclosed |
| EP-0497977-B1 | GASTRIC PREPARATION | NIPPON SHINYAKU CO LTD (JP) | 1995-03-15 | — | — | EP | disclosed |
| US-5368861-A | Gastric preparation with sustained release | NIPPON SHINYAKU CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| EP-0580861-A1 | CAPSULE | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1994-02-02 | — | — | EP | disclosed |
| EP-0580860-A1 | METHOD OF MANUFACTURING SOLID DISPERSION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1994-02-02 | — | — | EP | disclosed |
| EP-0497977-A1 | GASTRIC PREPARATION | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1992-08-12 | — | — | EP | disclosed |