Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 known ✓ | O95136 | 5/20 | 0.37 |
| ▸ | S1PR4 known ✓ | O95977 | 5/20 | 0.37 |
| ▸ | S1PR1 known ✓ | P21453 | 5/20 | 0.37 |
| ▸ | S1PR3 known ✓ | Q99500 | 5/20 | 0.37 |
| ▸ | S1PR5 known ✓ | Q9H228 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | ADH1B | P00325 | 2/20 | 0.45 |
| ▸ | ADH1C | P00326 | 2/20 | 0.45 |
| ▸ | ADH1A | P07327 | 2/20 | 0.45 |
| ▸ | ADH7 | P40394 | 2/20 | 0.45 |
| ▸ | ADH4 | P08319 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1977774 | 0.98 | KDM1A (0.56) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| Hydrochloric Acid SCHEMBL9052774 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL28960716 | 0.81 | KDM1A (0.56) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL8938917 | 0.80 | — | — | |
| SCHEMBL24157573 | 0.78 | KDM1A (0.64) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| Hydrochloric Acid SCHEMBL22771740 | 0.78 | TSHR (0.52) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL22157514 | 0.78 | KDM1A (0.58) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| Hydrochloric Acid SCHEMBL22771700 | 0.78 | KDM1A (0.58) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| Hydrochloric Acid SCHEMBL22771742 | 0.78 | TSHR (0.52) | KDM1ATSHRALDH1A1EPHX1ADH1B | |
| SCHEMBL20037699 | 0.78 | KDM1A (0.58) | KDM1ATSHRALDH1A1EPHX1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 884 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944746-B2 | Process for making organic-inorganic hybrid materials | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2018-04-17 | — | — | US | claimed |
| US-20140371386-A1 | PROCESS FOR MAKING ORGANIC-INORGANIC HYBRID MATERIALS | MOMENTIVE PERFORMANCE MATERIALS INC. | 2014-12-18 | — | — | US | claimed |
| WO-2014192037-A1 | ANTI-AEROSOL FILTERING ELEMENT, HAVING ANTIMICROBIAL ACTIVITIES, FOR NBC MASKS | OFFICINE MECCANICHE GALLI SRL (IT) | 2014-12-04 | — | — | WO | claimed |
| EP-2782965-A1 | PROCESS FOR MAKING ORGANIC-INORGANIC HYBRID MATERIALS | Momentive Performance Materials Inc. (US) | 2014-10-01 | — | — | EP | claimed |
| WO-2013078450-A1 | PROCESS FOR MAKING ORGANIC-INORGANIC HYBRID MATERIALS | MOMENTIVE PERFORMANCE MATERIALS, INC. (US) | 2013-05-30 | — | — | WO | claimed |
| WO-2012041658-A1 | AQUEOUS RINSE TREATMENT COMPOSITIONS | UNILEVER NV (NL) | 2012-04-05 | — | — | WO | claimed |
| US-20100314485-A1 | Center-Pull Dispenser for Web Material | NATIONAL TISSUE COMPANY LLC | 2010-12-16 | — | — | US | claimed |
| EP-1684623-A4 | DISPOSABLE CLEANING HEAD | CLOROX CO (US) | 2009-02-18 | — | — | EP | claimed |
| WO-2008081348-A2 | METHOD AND COMPOSITION FOR PERMANENTLY SHAPING HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2008-07-10 | — | — | WO | claimed |
| US-20080075681-A1 | Method and composition for permanently shaping hair | PROCTER & GAMBLE COMPANY, THE | 2008-03-27 | — | — | US | claimed |
| WO-1998056429-A1 | IMPROVED UNCOMPLEXED CYCLODEXTRIN COMPOSITIONS FOR ODOR CONTROL | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-17 | — | — | WO | claimed |
| WO-1998056889-A1 | FOOD CLEANING COMPOSITIONS CONTAINING CYCLODEXTRIN | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-17 | — | — | WO | claimed |
| WO-1998056888-A1 | UNCOMPLEXED CYCLODEXTRIN COMPOSITIONS FOR ODOR CONTROL | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-17 | — | — | WO | claimed |
| WO-1998056890-A1 | UNCOMPLEXED CYCLODEXTRIN COMPOSITIONS FOR ODOR AND WRINKLE CONTROL | THE PROCTER & GAMBLE COMPANY (US) | 1998-12-17 | — | — | WO | claimed |
| US-4863725-A | Novel clear oil-free moisturizer composition | SCHERING-PLOUGH HEALTHCARE PRODUCTS, INC. | 1989-09-05 | — | — | US | claimed |
| US-4851434-A | AMIDE OF DI-, TRI- OR POLYGLYCOL OR GLUCAMINE REACTION PRODUCT WITH D-HYDROXY ACID | REVLON CONSUMER PRODUCTS CORPORATION | 1989-07-25 | — | — | US | claimed |
| US-4783333-A | Cosmetic containing color particles | CHARLES OF THE RITZ GROUP, LTD. (US) | 1988-11-08 | — | — | US | claimed |
| US-4602648-A | CATIONIC SPECIES AND/OR PROTEIN | SOFT SHEEN PRODUCTS, INC. (US) | 1986-07-29 | — | — | US | claimed |
| US-4482537-A | COSMETICS, TOILETRIES | CHARLES OF THE RITZ GROUP LTD. (US) | 1984-11-13 | — | — | US | claimed |
| US-4426310-A | ETHOXYLATED SULFATE, POLYOXYETHYLENE GLYCOL SORBITAN MONOOLEATE, BETAINE | COLGATE-PALMOLIVE COMPANY (US) | 1984-01-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080075681-A1 | Method and composition for permanently shaping hair | AQP3, SLC3A2, SLC27A2 | S1PR2 408/4885S1PR4 1168/4885S1PR1 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.