Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.34 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 2/20 | 0.31 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27311115 | 0.86 | SLC1A1 (0.32) | — | |
| SCHEMBL3190190 | 0.84 | PTGS1 (0.40) | PTGS1SLC7A11ANPEPENPEP | |
| Potassium Ion SCHEMBL27967948 | 0.83 | SLC1A1 (0.32) | — | |
| SCHEMBL1644848 | 0.82 | SLC1A1 (0.37) | — | |
| SCHEMBL29155451 | 0.82 | SLC1A1 (0.46) | ANPEPENPEP | |
| SCHEMBL344252 | 0.81 | PTGS1 (0.52) | PTGS1SLC7A11ANPEPENPEP | |
| Potassium Ion SCHEMBL27402886 | 0.81 | SLC1A1 (0.35) | — | |
| SCHEMBL7927272 | 0.80 | PTGS1 (0.46) | PTGS1SLC7A11ANPEPENPEP | |
| SCHEMBL2873837 | 0.80 | PTGS1 (0.46) | PTGS1SLC7A11ANPEPENPEP | |
| SCHEMBL29223494 | 0.79 | SLC1A1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130157260-A1 | IDENTIFICATION OF COMPOUNDS THAT REGULATE APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-06-20 | — | — | US | disclosed |
| US-20100292145-A1 | METHODS OF REGULATING APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2010-11-18 | — | — | US | disclosed |
| US-7745574-B2 | Compounds that regulate apoptosis | THE BURNHAM INSTITUTE (US) | 2010-06-29 | — | — | US | disclosed |
| WO-2008154207-A9 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| WO-2008154207-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| US-7332161-B2 | Treatment of disease with antibodies against high molecular weight kininogen domain 5 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070054863-A1 | Compounds that regulate apoptosis | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
| WO-2006124537-A1 | COMPOUNDS THAT REGULATE APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2006-11-23 | — | — | WO | disclosed |
| US-20060115471-A1 | Treatment of disease with antibodies against high molecular weight kininogen domain 5 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH OF HIGHER EDUCATION (US) | 2006-06-01 | — | — | US | disclosed |
| US-6284726-B1 | ADMINISTERING POLYPEPTIDE | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2001-09-04 | — | — | US | disclosed |
| WO-2001056591-A1 | vMIP-II PEPTIDE ANTAGONISTS OF CXCR4 | THOMAS JEFFERSON UNIVERSITY (US) | 2001-08-09 | — | — | WO | disclosed |
| WO-2001034195-A1 | INHIBITION OF ANGIOGENESIS BY ANTIBODIES AGAINST HIGH MOLECULAR WEIGHT KININOGEN DOMAIN 5 | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2001-05-17 | — | — | WO | disclosed |
| EP-1044012-A1 | INHIBITION OF ANGIOGENESIS BY PEPTIDE ANALOGS OF HIGH MOLECULAR WEIGHT KININOGEN DOMAIN 5 | Temple University of the Commonwealth System of Higher Education (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-2000059526-A1 | ENHANCEMENT OF PEPTIDE CELLULAR UPTAKE | THOMAS JEFFERSON UNIVERSITY (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000059928-A1 | CHEMOKINE-DERIVED SYNTHETIC PEPTIDES | THOMAS JEFFERSON UNIVERSITY (US) | 2000-10-12 | — | — | WO | disclosed |
| WO-2000035407-A2 | INHIBITION OF ANGIOGENESIS BY HIGH MOLECULAR WEIGHT KININOGEN DOMAIN 3 PEPTIDE ANALOGS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-06-22 | — | — | WO | disclosed |
| WO-2000027415-A2 | INHIBITION OF ANGIOGENESIS BY PEPTIDE ANALOGS OF HIGH MOLECULAR WEIGHT KININOGEN DOMAIN 5 | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000027866-A1 | INHIBITION OF ANGIOGENESIS BY HIGH MOLECULAR WEIGHT KININOGEN AND PEPTIDE ANALOGS THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-1999033342-A1 | METHOD OF SUPPRESSING TUMOR CELL GROWTH BY ADMINISTERING DECORIN | THOMAS JEFFERSON UNIVERSITY (US) | 1999-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | PTGS1 1814/4885SLC7A11 4690/4885ANPEP 3172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.