Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27320633 | 1.00 | ALDH1A1 (0.57) | — | |
| Bromide SCHEMBL27374968 | 0.97 | ALDH1A1 (0.55) | — | |
| Hydrochloric Acid SCHEMBL27371342 | 0.97 | ALDH1A1 (0.55) | — | |
| SCHEMBL17449766 | 0.97 | — | — | |
| SCHEMBL10901590 | 0.97 | ALDH1A1 (0.60) | — | |
| SCHEMBL1866106 | 0.97 | ALDH1A1 (0.60) | — | |
| SCHEMBL6115 | 0.97 | — | — | |
| SCHEMBL23930216 | 0.94 | — | — | |
| SCHEMBL1506847 | 0.94 | — | — | |
| SCHEMBL22288371 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022008971-A2 | TREATMENT OF SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS INFECTION WITH KLOTHO | Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) (CR) | 2022-01-13 | — | — | WO | disclosed |
| CN-110240561-A | A kind of preparation method of the 3- pyridone of low cost | 新发药业有限公司 | 2019-09-17 | — | — | CN | disclosed |
| CN-106349156-B | It can be used as the pyridine -2- amides of CB2 agonist | 霍夫曼-拉罗奇有限公司 | 2018-12-11 | — | — | CN | disclosed |
| CN-104306974-B | The method of the ephrosis for the treatment of contrast agent induction | 诺华股份有限公司 | 2017-06-13 | — | — | CN | disclosed |
| US-9561272-B2 | Compositions and methods for modulating immune responses | THE UNIVERSITY OF QUEENSLAND (AU) | 2017-02-07 | — | — | US | disclosed |
| CN-103896796-B | As the alanine derivatives of the replacement of enkephalinase inhibitor | NOVARTIS AG (CH) | 2016-04-27 | — | — | CN | disclosed |
| CN-105008337-A | Substituted bisphenyl butanoic acid derivatives as NEP inhibitors with improved in vivo efficacy | NOVARTIS AG | 2015-10-28 | — | — | CN | disclosed |
| US-20150216955-A1 | IMMUNOMODULATORY AGENT AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-08-06 | — | — | US | disclosed |
| US-20150202285-A1 | COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-07-23 | — | — | US | disclosed |
| US-9017697-B2 | Compositions and methods for modulating immune responses | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-04-28 | — | — | US | disclosed |
| CN-1468215-A | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | ����ҩƷ��ҵ��ʽ���� | 2004-01-14 | — | — | CN | disclosed |
| CN-1437587-A | Benzoxazepinones and their use as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-08-20 | — | — | CN | disclosed |
| CN-1372553-A | Novel thiazine or pyrazine derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 2002-10-02 | — | — | CN | disclosed |
| CN-1075388-C | Cascade polymers with iodine aromatic compounds | SCHERING AG (DE) | 2001-11-28 | — | — | CN | disclosed |
| CN-1043647-C | Novel peptide compounds | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-06-16 | — | — | CN | disclosed |
| CN-1200736-A | Peptide derivatives | DAIICHI SEIYAKU CO (JP) | 1998-12-02 | — | — | CN | disclosed |
| CN-1182419-A | Novel pyridine derivatives and medicine containing the same as active ingredient | SS PHARMACEUTICAL CO (JP) | 1998-05-20 | — | — | CN | disclosed |
| CN-1137759-A | Cascade polymers with iodine aromatic compounds | SCHERING AG (DE) | 1996-12-11 | — | — | CN | disclosed |
| CN-1032308-C | Process for preparing optically active 2-oxoimidazolidine derivatives | TANABE SEIYAKU CO (JP) | 1996-07-17 | — | — | CN | disclosed |
| US-4607123-A | X-RAY CONTRAST AGENTS | DR. FRANZ KOHLER CHEMIE GMBH (DE) | 1986-08-19 | — | — | US | disclosed |