SCHEMBL344398

SCHEMBL344398

O=C(O)c1cc(O)ccc1OCc1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FOLH1 Q04609 4/20 0.70
L3MBTL1 Q9Y468 2/20 0.63
KDM4E B2RXH2 1/20 0.63
ALDH1A1 P00352 1/20 0.63
POLB P06746 1/20 0.63
MCL1 Q07820 3/20 0.56
GAA P10253 1/20 0.55
PTGER1 P34995 1/20 0.55
MAPT P10636 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CHRM4 P08173 1/20 0.52
CHRM3 P20309 1/20 0.52
CLCN2 P51788 1/20 0.52
SGMS2 Q8NHU3 2/20 0.51
ELANE P08246 2/20 0.51
CTSV O60911 1/20 0.51
CTSL P07711 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9431930 0.87 L3MBTL1 (0.65) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL321453 0.87 PARP1 (0.57) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL5583147 0.87 MCL1 (0.63) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL10089235 0.86 FOLH1 (0.69) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL1649243 0.85 FOLH1 (0.68) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL384896 0.85 FOLH1 (0.68) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL344833 0.85 FOLH1 (0.68) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL1647498 0.84 FOLH1 (0.63) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL1647381 0.84 FOLH1 (0.67) FOLH1L3MBTL1KDM4EALDH1A1POLB
SCHEMBL1646699 0.84 FOLH1 (0.67) FOLH1L3MBTL1KDM4EALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 67 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9198886-B2 Use of 2,5-dihydroxybenzene for the treatment of ocular diseases CUEVAS SÁNCHEZ PEDRO (ES) 2015-12-01 US claimed
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN ACTION MEDICINES, S.L. (ES) 2014-07-24 US claimed
EP-2061453-B1 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES SL (ES) 2013-03-13 EP claimed
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES (ES) 2012-01-19 US claimed
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES (ES) 2011-10-20 US claimed
EP-2061453-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS Action Medicines, S.L. (ES) 2009-05-27 EP claimed
EP-2056805-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP claimed
EP-2056804-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP claimed
EP-2054051-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS Investread Europe, S.L. (ES) 2009-05-06 EP claimed
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ACTION MEDICINES (ES) 2008-05-29 US claimed
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy ACTION MEDICINES (ES) 2008-05-29 US claimed
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases ACTION MEDICINES (ES) 2008-05-15 US claimed
WO-2008020039-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020031-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ANGIOGENIC DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020037-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING OBESITY, HIRSUTISM, HYPERTRICOSIS AND VIRAL WARTS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020034-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF HEMANGIOMAS OR HEMANGIOBLASTOMAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020042-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020025-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2008020032-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO claimed
WO-2025242903-A1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF PROLIFERATIVE DISEASES ONCO3R THERAPEUTICS BV (BE) 2025-11-27 WO disclosed
CN-117794526-A Compositions and methods for antioxidants and anti-inflammatory therapeutics 阿万蒂生物科学股份有限公司 2024-03-29 CN disclosed
US-20190192474-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC 2019-06-27 US disclosed
US-10278940-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2019-05-07 US disclosed
US-20170065547-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer ACTION MEDICINES, S.L. (ES) 2017-03-09 US disclosed
US-9511044-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2016-12-06 US disclosed
US-9248114-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ ACTION MEDICINES, S.L. (ES) 2016-02-02 US disclosed
US-9198886-B2 Use of 2,5-dihydroxybenzene for the treatment of ocular diseases CUEVAS SÁNCHEZ PEDRO (ES) 2015-12-01 US disclosed
US-9060966-B2 Use of 2,5-dihydroxybenzene derivatives for the treatment of arthritis and pain CUEVAS SÁNCHEZ PEDRO (ES) 2015-06-23 US disclosed
US-9018195-B2 Use of 2,5-dihydroxybenzene sulfonic acid compounds for treating skin photoaging AmDerma Pharmaceuticals, LLC (US) 2015-04-28 US disclosed
US-8889737-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2014-11-18 US disclosed
US-20140328823-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC 2014-11-06 US disclosed
EP-2483254-B1 NOVEL COMPOUNDS GLAXO GROUP LTD (GB) 2014-08-13 EP disclosed
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN ACTION MEDICINES, S.L. (ES) 2014-07-24 US disclosed
US-8778939-B2 Compounds GLAXO GROUP LIMITED (GB) 2014-07-15 US disclosed
US-8541467-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of hematological dyscrasias and cancer of an organ ACTION MEDICINES, S.L. (ES) 2013-09-24 US disclosed
US-20130202580-A1 Use Of 2,5-Dihydroxybenzene Derivatives For Treating Actinic Keratosis AmDerma Pharmaceuticals, LLC (US) 2013-08-08 US disclosed
US-8436045-B2 Use of 2,5-dihydroxybenzene derivatives for treating actinic keratosis AmDerma Pharmaceuticals, LLC (US) 2013-05-07 US disclosed
EP-2061453-B1 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES SL (ES) 2013-03-13 EP disclosed
EP-2483254-A1 NOVEL COMPOUNDS Glaxo Group Limited (GB) 2012-08-08 EP disclosed
US-20120184553-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2012-07-19 US disclosed
US-20120087904-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer AmDerma Pharmaceuticals, LLC (US) 2012-04-12 US disclosed
US-8101660-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer AmDerma Pharmaceuticals, LLC (US) 2012-01-24 US disclosed
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES (ES) 2012-01-19 US disclosed
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES (ES) 2011-10-20 US disclosed
US-20110152222-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN SANCHEZ PEDRO CUEVAS 2011-06-23 US disclosed
WO-2011038572-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2011-04-07 WO disclosed
EP-2061453-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS Action Medicines, S.L. (ES) 2009-05-27 EP disclosed
EP-2056805-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP disclosed
EP-2056804-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES Action Medicines, S.L. (ES) 2009-05-13 EP disclosed
EP-2054051-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS Investread Europe, S.L. (ES) 2009-05-06 EP disclosed
EP-2054045-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN Action Medicines, S.L. (ES) 2009-05-06 EP disclosed
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ACTION MEDICINES (ES) 2008-05-29 US disclosed
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy ACTION MEDICINES (ES) 2008-05-29 US disclosed
US-20080114060-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy with other drugs or photodynamic therapy ACTION MEDICINES (ES) 2008-05-15 US disclosed
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases ACTION MEDICINES (ES) 2008-05-15 US disclosed
WO-2008020039-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR TREATING CANCERS AND HEMATOLOGICAL DYSCRASIAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020027-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF SKIN CANCER ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020031-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ANGIOGENIC DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020037-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING OBESITY, HIRSUTISM, HYPERTRICOSIS AND VIRAL WARTS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020040-A2 2,5-DIHYDROXYBENZENE COMPOUNDS FOR THE TREATMENT OF FIBROSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020034-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF HEMANGIOMAS OR HEMANGIOBLASTOMAS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020033-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020042-A1 USE OF 2, 5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF TISSUE REACTIVE DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020032-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF OCULAR DISEASES ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
WO-2008020025-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS ACTION MEDICINES, S.L. (ES) 2008-02-21 WO disclosed
US-20050075375-A1 Heterocyclic compounds for treating hepatitis C virus ANADYS PHARMACEUTICALS, INC. (US) 2005-04-07 US disclosed
WO-2004110351-A2 HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS ANADYS PHARMACEUTICALS, INC. (US) 2004-12-23 WO disclosed
WO-2004110351-A2 HETEROCYCLIC COMPOUNDS FOR TREATING HEPATITIS C VIRUS ANADYS PHARMACEUTICALS, INC. (US) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (16 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125485-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid; skin disorders like skin wrinkles, actinic keratosis, skin pigmentation and hyperpigmentation, hirsutism and hypertricosis, obesity due to adipogenesis ARSA, CYP8B1, EBP FOLH1 2945/4885L3MBTL1 1572/4885KDM4E 1639/4885
US-20080125486-A1 sultosilic acid, 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, used for improving the efficacy of chemotherapy, radiotherapy and/or cancer immunotherapy STS, MPST, TST FOLH1 2122/4885L3MBTL1 1107/4885KDM4E 1472/4885
US-20140328823-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 FOLH1 1079/4885L3MBTL1 2095/4885KDM4E 540/4885
US-20120087904-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 FOLH1 1079/4885L3MBTL1 2095/4885KDM4E 540/4885
US-10278940-B2 Use of 2,5-dihydroxybenzene compounds and derivatives for the treatment of skin cancer CYP8B1, CYP26B1, CYP24A1 FOLH1 1079/4885L3MBTL1 2095/4885KDM4E 540/4885
US-20130202580-A1 Use Of 2,5-Dihydroxybenzene Derivatives For Treating Actinic Keratosis CYP8B1, DERA, KRT18 FOLH1 1186/4885L3MBTL1 3247/4885KDM4E 1371/4885
US-20050075375-A1 Heterocyclic compounds for treating hepatitis C virus HAVCR2, HCCS, LIPC FOLH1 1682/4885L3MBTL1 4366/4885KDM4E 3106/4885
US-20120184553-A1 NOVEL COMPOUNDS LRRK2, PARK7, PINK1 FOLH1 4250/4885L3MBTL1 1685/4885KDM4E 3000/4885
US-20080114063-A1 Use of 2,5-Dihydroxybenzene Derivatives for the Treatment of Tissue Reactive Diseases CYP11B1, CYP11B2, MYLK FOLH1 1263/4885L3MBTL1 3528/4885KDM4E 3075/4885
US-20170065547-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 FOLH1 1079/4885L3MBTL1 2095/4885KDM4E 540/4885
US-20120015912-A1 USE OF 2,5-DIHYDROXYBENZENE FOR THE TREATMENT OF OCULAR DISEASES ALDH1A2, CRYAB, HSD17B14 FOLH1 2602/4885L3MBTL1 4541/4885KDM4E 1092/4885
US-20190192474-A1 Use Of 2,5-Dihydroxybenzene Compounds And Derivatives For The Treatment Of Skin Cancer CYP8B1, CYP26B1, CYP24A1 FOLH1 1079/4885L3MBTL1 2095/4885KDM4E 540/4885
US-20080114060-A1 2-(acetyloxy)-5-hydroxybenzenesulfonic acid, or 5-(acetyloxy)-2-hydroxybenzene-sulfonic acid, or 2,5-bis(acetyloxy)benzenesulfonic acid, or sultosilic acid for example; combination therapy with other drugs or photodynamic therapy ALAD, ARSA, STS FOLH1 1671/4885L3MBTL1 1695/4885KDM4E 3500/4885
US-20140206654-A1 USE OF 2,5-DIHYDROXYBENZENE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT OF HEMATOLOGICAL DYSCRASIAS AND CANCER OF AN ORGAN HMBS, HCLS1, CYP2S1 FOLH1 1221/4885L3MBTL1 1009/4885KDM4E 821/4885
US-20110257264-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR TREATING ACTINIC KERATOSIS CYP8B1, DERA, KRT18 FOLH1 1186/4885L3MBTL1 3247/4885KDM4E 1371/4885
US-20110152222-A1 USE OF 2,5-DIHYDROXYBENZENE DERIVATIVES FOR THE TREATMENT OF ARTHRITIS AND PAIN CYP8B1, CYP26B1, UGT2B7 FOLH1 1846/4885L3MBTL1 3750/4885KDM4E 1627/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.