Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.42 |
| ▸ | GAA known ✓ | P10253 | 2/20 | 0.42 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.48 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22457 | 0.98 | KDM4E (0.53) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| SCHEMBL9719672 | 0.96 | KDM4E (0.52) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| SCHEMBL9789528 | 0.96 | KDM4E (0.56) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| Bromide SCHEMBL8174299 | 0.96 | KDM4E (0.52) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| Ammonia Solution, Strong SCHEMBL3951628 | 0.96 | KDM4E (0.52) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| SCHEMBL29979349 | 0.94 | KDM4E (0.50) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| SCHEMBL29436298 | 0.94 | KDM4E (0.50) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| Cyanide SCHEMBL9847521 | 0.92 | KDM4E (0.49) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| Acetic Acid SCHEMBL22444416 | 0.92 | KDM4E (0.49) | KDM4EHSD17B10CDC25ACDC25BPOLB | |
| Urea SCHEMBL5149485 | 0.92 | KDM4E (0.49) | KDM4EHSD17B10CDC25ACDC25BPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9190647-B2 | Nonaqueous electrolyte secondary battery with high temperature and storage characteristics | PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD. (JP) | 2015-11-17 | — | — | US | claimed |
| US-7843045-B2 | Thermoplastic resin composition for semiconductor, adhesion film, lead frame, and semiconductor device using the same, and method of producing semiconductor device | HITACHI CHEMICAL CO., LTD. (JP) | 2010-11-30 | — | — | US | claimed |
| US-20090091012-A1 | THERMOPLASTIC RESIN COMPOSITION FOR SEMICONDUCTOR, ADHESION FILM, LEAD FRAME, AND SEMICONDUCTOR DEVICE USING THE SAME, AND METHOD OF PRODUCING SEMICONDUCTOR DEVICE | HITACHI CHEMICAL CO., LTD. (JP) | 2009-04-09 | — | — | US | claimed |
| JP-58167580-A | — | — | None | — | — | JP | disclosed |
| JP-58167580-A | — | — | None | — | — | JP | disclosed |
| JP-61044928-A | — | — | None | — | — | JP | disclosed |
| JP-5009254-A | — | — | None | — | — | JP | disclosed |
| JP-5239347-A | — | — | None | — | — | JP | disclosed |
| JP-2168618-A | — | — | None | — | — | JP | disclosed |
| JP-61195127-A | — | — | None | — | — | JP | disclosed |
| JP-61195128-A | — | — | None | — | — | JP | disclosed |
| JP-S61195128-A | PRODUCTION OF POLYAMIDE IMIDE COPOLYMER FOR MOLDING | TORAY IND INC | 1986-08-29 | — | — | JP | disclosed |
| JP-S6144929-A | PRODUCTION OF AROMATIC POLYAMIDE-IMIDE | TORAY IND INC | 1986-03-04 | — | — | JP | disclosed |
| JP-S6144928-A | PRODUCTION OF AROMATIC POLYAMIDE-IMIDE | TORAY IND INC | 1986-03-04 | — | — | JP | disclosed |
| JP-S58167580-A | PRODUCTION OF HIGH-PURITY TRIMELLITIC ANHYDRIDE MONOCHLORIDE | TORAY IND INC | 1983-10-03 | — | — | JP | disclosed |
| JP-S58167580-A | PRODUCTION OF HIGH-PURITY TRIMELLITIC ANHYDRIDE MONOCHLORIDE | TORAY IND INC | 1983-10-03 | — | — | JP | disclosed |
| US-4058503-A | FROM AN ANHYDRIDE AND A DIHYDRAZIDE | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1977-11-15 | — | — | US | disclosed |
| US-3978154-A | PROCESS FOR THE MANUFACTURE OF IMPROVED ELASTOMERS PREPARED BY REACTION OF TRIMELLITOYL-FUNCTIONAL POLYMER WITH EPOXY COMPOUND | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1976-08-31 | — | — | US | disclosed |
| US-3963664-A | METAPHENYLENE ISOPHTHALAMIDE, N-METHYL-2-PYRROLIDONE, SLURRYING, HEATING | TEIJIN LIMITED (JA) | 1976-06-15 | — | — | US | disclosed |
| US-3960980-A | Method of producing elastomer resins | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1976-06-01 | — | — | US | disclosed |