Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Trimetazidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.97 |
| ▸ | OPRK1 known ✓ | P41145 | 2/20 | 0.97 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.97 |
| ▸ | OPRD1 known ✓ | P41143 | 1/20 | 0.97 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.54 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.54 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.54 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.54 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.54 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.54 |
| ▸ | CACNA1B known ✓ | Q00975 | 1/20 | 0.54 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.54 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.54 |
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimetazidine SCHEMBL2901538 | 1.00 | APOBEC3A (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL580378 | 1.00 | APOBEC3A (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL29605009 | 1.00 | APOBEC3A (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL29677959 | 1.00 | APOBEC3A (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL29375563 | 0.98 | CHRM2 (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL11846840 | 0.98 | CHRM2 (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL230374 | 0.98 | CHRM2 (1.00) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL15302482 | 0.97 | CHRM2 (0.97) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL3896420 | 0.97 | CHRM2 (0.97) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 | |
| Trimetazidine SCHEMBL12485382 | 0.95 | CHRM2 (0.94) | APOBEC3ACTDSP1APOBEC3GCHRM2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 434 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118420566-B | Preparation method of high-purity trimetazidine hydrochloride | 海南锦麟医药科技有限公司 | 2025-03-11 | — | — | CN | claimed |
| CN-119280242-A | Application of trimetazidine dihydrochloride in medicine for preventing and treating melanoma and brain glioma | 中国医学科学院药物研究所 | 2025-01-10 | — | — | CN | claimed |
| CN-118777471-A | Trimetazidine hydrochloride sustained release tablet quality detection device | 湖南明瑞制药股份有限公司 | 2024-10-15 | — | — | CN | claimed |
| CN-117797152-B | Medicine for protecting cell nourishing myocardial cells and preparation method thereof | 海南锦麟医药科技有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-118420566-A | Preparation method of high-purity trimetazidine hydrochloride | 海南锦麟医药科技有限公司 | 2024-08-02 | — | — | CN | claimed |
| CN-116041280-B | Preparation method of trimetazidine hydrochloride | 三峡大学 | 2024-07-05 | — | — | CN | claimed |
| CN-117797152-A | Medicine for protecting cell nourishing myocardial cells and preparation method thereof | 海南锦麟医药科技有限公司 | 2024-04-02 | — | — | CN | claimed |
| CN-117398354-A | Levocarnitine trimetazidine double-layer tablet | 常州高新技术产业开发区三维工业技术研究所有限公司 | 2024-01-16 | — | — | CN | claimed |
| CN-116046924-A | HPLC detection method and application of trimetazidine hydrochloride | 北京诺康达医药科技股份有限公司 | 2023-05-02 | — | — | CN | claimed |
| CN-116041280-A | Preparation method of trimetazidine hydrochloride | 三峡大学 | 2023-05-02 | — | — | CN | claimed |
| EP-2995308-A1 | ANTIHYPOXIC PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Changzhou Hi-tech District Multiple Dimension Industry Technology Institute CO., LTD. (CN) | 2016-03-16 | — | — | EP | claimed |
| WO-2011112160-A1 | EXTENDED RELEASE TRIMETAZIDINE TABLETS | ALI RAIF ILAC SANAYI VE TICARET A.S. (TR) | 2011-09-15 | — | — | WO | claimed |
| CN-102140084-A | Production method of trimetazidine and hydrochloride thereof | LIAONING BENYUAN PHARMACEUTICAL CO LTD | 2011-08-03 | — | — | CN | claimed |
| CN-101575321-A | Trimetazidine and production method of hydrochloride thereof | UNIV SHAOXING (CN) | 2009-11-11 | — | — | CN | claimed |
| CN-101455667-A | Preparation of trimetazidine hydrochloride gastric floating tablets and use thereof | BEIJING HOPE HUGE PHARM SCI CO (CN) | 2009-06-17 | — | — | CN | claimed |
| CN-101283992-A | Trimetazidine hydrochloride dispersible tablet and preparation method thereof | CHUANLIANG HU (CN) | 2008-10-15 | — | — | CN | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5288503-A | WATER-PERMEABLE DIFFUSION BARRIER OF POLYVINYL ALCOHOL | SRCHEM INCORPORATED (US) | 1994-02-22 | — | — | US | claimed |
| US-5260066-A | Cryogel bandage containing therapeutic agent | SRCHEM INCORPORATED (US) | 1993-11-09 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |