Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Cyclopropane Carboxylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9540139 | 1.00 | TSHR (0.58) | — | |
| Cyclopropane Carboxylic Acid SCHEMBL31174891 | 1.00 | TSHR (0.58) | — | |
| Hydrochloric Acid SCHEMBL2060062 | 1.00 | TSHR (0.58) | — | |
| Hydrochloric Acid SCHEMBL1060402 | 1.00 | TSHR (0.58) | — | |
| Hydrochloric Acid SCHEMBL890381 | 1.00 | TSHR (0.58) | — | |
| Cyclopropane Carboxylic Acid SCHEMBL15821707 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL2060066 | 1.00 | TSHR (0.58) | — | |
| Cyclopropane Carboxylic Acid SCHEMBL5499291 | 0.96 | — | — | |
| SCHEMBL26833 | 0.96 | TSHR (0.61) | — | |
| Cyclopropane Carboxylic Acid SCHEMBL4643 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 986 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919133-B2 | Substituted cyclopropanecarboxylic acid (3-methyl-cyclohexyl)amide as flavoring substance | SYMRISE GMBH & CO. KG (DE) | 2011-04-05 | — | — | US | claimed |
| EP-1989944-B1 | Substituted cyclopropane carbolic acid(3-methyl-cyclohexyl)amides as taste substances | SYMRISE GMBH & CO KG (DE) | 2010-06-02 | — | — | EP | claimed |
| US-20080292763-A1 | Substituted Cyclopropanecarboxylic acid (3-methyl-cyclohexyl)amide as flavoring substance | SYMRISE GMBH & CO. KG (DE) | 2008-11-27 | — | — | US | claimed |
| EP-0494146-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE OR RACEMIC CYCLOPROPANE-CARBOXYLIC-ACID CHLORIDES | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1995-10-25 | — | — | EP | claimed |
| EP-0494146-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE OR RACEMIC CYCLOPROPANE-CARBOXYLIC-ACID CHLORIDES. | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1992-07-15 | — | — | EP | claimed |
| WO-1992002482-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE OR RACEMIC CYCLOPROPANE-CARBOXYLIC-ACID CHLORIDES | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) | 1992-02-20 | — | — | WO | claimed |
| EP-0434357-A2 | Fungicides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-06-26 | — | — | EP | claimed |
| EP-0312124-A2 | Process for the preparation of optically-active cyanomethyl esters | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-04-19 | — | — | EP | claimed |
| US-4723027-A | TREATING AN ALDEHYDE WITH HYDROGEN CYANIDE IN THE PRESENCE OF CYCLO(D-PHENYLALANYL-D-HISTIDINE)CATALYST | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1988-02-02 | — | — | US | claimed |
| EP-0112133-B1 | 5-PHENYLETHENYLBENZIMIDAZOLES | SMITHKLINE BECKMAN CORPORATION (US) | 1987-10-21 | — | — | EP | claimed |
| EP-0112133-A1 | 5-Phenylethenylbenzimidazoles | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-27 | — | — | EP | claimed |
| EP-0109681-A2 | process for the preparation of optically-active cyanomethyl esters | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-05-30 | — | — | EP | claimed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | claimed |
| US-4211727-A | CADMIUM BOROHYDRIDE COMPLEX AS REDUCING AGENT | SHELL OIL COMPANY (US) | 1980-07-08 | — | — | US | claimed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | claimed |
| JP-55102551-A | — | — | None | — | — | JP | disclosed |
| JP-1157964-A | — | — | None | — | — | JP | disclosed |
| US-3944675-A | Substituted aryl and aralkyl amides in the treatment of parkinsonism | SCHERING CORPORATION (US) | 1976-03-16 | — | — | US | disclosed |
| US-3931216-A | Process for the manufacture of 2-arylamino-2-imidazoline derivatives and their salts | BOEHRINGER INGELHEIM GMBH (DT) | 1976-01-06 | — | — | US | disclosed |
| US-3931153-A | BACTERICIDE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-06 | — | — | US | disclosed |